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Found 412 clinical trials
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Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic Inflammatory and Takotsubo Cardiomyopathy (MEMORY)

demonstrated the utility of manganese-enhanced MRI (MEMRI) in assessing infarct size more accurately than with standard cardiac MRI protocols using gadolinium enhancement and have shown reduced myocardial

angiography
Accepts healthy volunteers
MRI
cardiac mri
electrocardiogram
  • 27 views
  • 18 Oct, 2021
  • 1 location
None
Natural History Study of CADASIL

Background CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy) is a genetic disorder. It causes narrowing of the

arteriopathy
infarct
Accepts healthy volunteers
  • 0 views
  • 19 Jan, 2022
  • 1 location
None
Epidemiology of Silent and Overt Strokes in Sickle Cell Disease

Sickle Cell Disease (SCD) is a rare disease occurring in an estimated 100,000 individuals, often poor and underserved, in the US. Silent and overt strokes contribute significantly to morbidity in adults with SCD, resulting in functional impairment, challenges with school and job performance, and premature death. Five NIH-funded randomized controlled …

blood transfusion
infarct
recurrent strokes
hydroxyurea
diabetes
  • 50 views
  • 01 Nov, 2021
  • 6 locations
None
Evaluation of Small Vessel Disease by 3D-rotational Angiography

This study is aimed to elucidate the factors affecting the remodeling process of arteriolosclerosis under current practice recommendations. Such knowledge may improve the understanding of cerebral small vessel disease (cSVD) mechanism, define pharmacological therapy and suggest treatment target.

  • 0 views
  • 26 Jan, 2021
  • 1 location
None
Metabolic Phenotyping and Follow-Up of Patients With and Without Diabetes After New Onset of STEMI

The aim of the prospective observational DISTEMI-Study in patients with and without Diabetes mellitus after new onset of ST-Elevation Myocardial Infarction (STEMI) aged 18-80 years at inclusion into the study is to characterize in detail the clinical, metabolical, immunological and vascular phenotype, investigate the interplay beween myocardial remodelling and the …

hemoglobin a1c
stemi
oral glucose tolerance test
diabetes
glucose tolerance test
  • 0 views
  • 24 Sep, 2021
  • 1 location
None
Left Ventricular Structural Predictors of Sudden Cardiac Death

Sudden cardiac death (SCD) poses a significant health care challenge with high annual incidence and low survival rates. Implantable cardioverter defibrillators (ICDs) prevent SCD in patients with poor heart function. However, the critical survival benefit afforded by the devices is accompanied by short and long-term complications and a high economic …

ejection fraction
cardiac death
MRI
primary prevention
  • 28 views
  • 25 Jul, 2021
  • 2 locations
None
Functional Near Infrared Spectroscopy in Adult Cardiac Surgery

Brain injury is a serious problem after cardiac surgery. Brain injury can become evident in the form of stroke and cognitive dysfunction after surgery. The current neuromonitoring technique used is unable to monitor the region of the brain that is most susceptible to injury. This study aims to use a …

stroke
  • 0 views
  • 24 Feb, 2021
  • 1 location
None
Study of Circulating Monocytes in Patients With Ischemic Vascular Disease

The purpose of this research study is to discover the functions of circulating white blood cells, called monocytes, and associated circulating substances in heart attack and ischemic stroke patients. Ischemic Strokes (clots) occur as a result of an obstruction within a blood vessel supplying blood to the brain. A type …

clot
hypertension
traumatic brain injury
stroke
acute coronary syndrome
  • 0 views
  • 15 Oct, 2021
  • 1 location
None
Evaluation of Patient Stress Level Caused by Radiological Investigations in Early Postoperative Phase After Craniotomy

Postoperative imaging after neurosurgical intervention is usually performed in the first 72 hours after surgery. Postoperative radiological examinations in the first 72 hours provide accurate assessment of postoperative resection status. On the other side is frequently reported by patients that the earlier postoperative examinations after craniotomy for tumor and vascular …

discomfort
nausea
  • 0 views
  • 15 Nov, 2021
  • 1 location
None
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics (CREST-H)

We aim to determine whether cognitive impairment attributable to cerebral hemodynamic impairment in patients with high-grade asymptomatic carotid artery stenosis is reversible with restoration of flow. To accomplish this aim CREST-H will add on to the NINDS-sponsored CREST-2 trial (parallel, outcome-blinded Phase 3 clinical trials for patients with asymptomatic high-grade …

carotid disease
carotid revascularization
stroke
cognitive decline
stenosis
  • 36 views
  • 25 Jan, 2021
  • 54 locations