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Found 213 clinical trials
Study of CT and MR in the Gastric Cancer

It is very significant that assessing staging in gastric cancer patients before surgery, furthermore, determining the optimize surgical strategy ,predict the the efficacy of neoadjuvant therapy for patients. For patients who are ineffective in neoadjuvant therapy, surgery will be more meaningful. It has been reported that the application of CT(computed …

  • 03 Mar, 2022
  • 1 location
Relationship Between Baseline Burden of Disease and TDM in Ulcerative Colitis

whether measures of high burden of disease (fecal calprotectin, bowel ultrasound, and colonoscopy) at baseline predicts low drug levels after standard anti-TNF induction therapy.

faecal calprotectin
flexible sigmoidoscopy
inflammatory bowel disease
tumor necrosis factor
  • 28 Feb, 2022
  • 1 location
Continuous Ambulatory Monitoring to Predict Elevated Risk of Infection in Children With Lymphoblastic Leukemia Undergoing Induction Chemotherapy (CAMPER-ALL)

Acute lymphoblastic leukemia (ALL) is the most common cancer of childhood and long-term survival has risen to above 90%, but 1-4% of treated patients die from infections. Early detection and treatment of infection can improve these outcomes by preventing increased severity and death. This study aims to determine whether continuous …

lymphoid leukemia
induction therapy
  • 19 Aug, 2022
  • 1 location
Monitoring Minimal Residual Disease MRD in Pediatric B-acute Lymphoblastic Leukemia

This study aimed to investigate the performance of next-generation sequencing (NGS) techniques measuring immunoglobulin heavy chain (IgH)-variable, diversity, and joining (V[D]J) clonal rearrangements IgH-V[D]J NGS compared with flow cytometry (FCM) in detecting of minimal residual disease (MRD) for children with acute lymphoblastic leukemia treated with South Chinese Children Leukemia Group …

  • 04 Aug, 2021
  • 1 location
ALLoreactive T-Cell receptOr RePertoire in kidnEy tranSplantation (ALL-T-COPIES)

In this study, the investigators will establish a workflow to generate unique patterns of the donor-reactive T cell repertoire using mixed lymphocyte reactions to select alloreactive T cell clones prior to transplantation Tissue infiltrating as well as blood bound T cells will be characterized based on: Identification of donor-specific T …

kidney transplant
kidney biopsy
  • 24 Apr, 2022
  • 1 location
Pharmacokinetics and Immunogenicity of the First Doses of PEG-Asparaginase -An ALLTogether Pilot Study

Acute lymphoblastic leukemia (ALL) is the most common malignant disease in childhood. Survival rates exceed 90% in children and 75% in adults (aged 18-45 years). During the induction period Asparaginase is an indispensable part of the multiagent treatment, but is often associated with hypersensitivity, either with clinical allergy or silent …

  • 18 Apr, 2021
  • 2 locations
RWE of Pediatric-like Protocol for AYA Patients With Ph-negative ALL

This is a multicenter, observational real world clinical trial with prospective follow up that will evaluate the treatment outcome of adolescent and young patients with ph-negative acute lymphoblastic leukemia with first-line pediatric-like protocol in Argentina.

  • 26 Nov, 2021
  • 1 location
Prospective Observational Study of Long-term Pathogenic Treatment of Elizaria® (NAP)

This is prospective observational study of long-term pathogenic treatment of Elizaria® in patients with paroxysmal nocturnal hemoglobinuria.

  • 26 Mar, 2022
  • 8 locations
Evaluation of Maintenance With Bortezomib Plus Daratumumab (V-Dara) After Induction With Bortezomib, Melphalan, Prednisone Plus Daratumumab (VMP-Dara) in Newly Diagnosed Multiple Myeloma (MM) Patients Non-eligible for autoSCT

This is a prospective, observational, single group and multicenter study to describe the effectiveness and safety of maintenance with V-Dara after induction with the VMP-Dara regimen in newly diagnosed MM patients who are not eligible for ASCT. Patients will be enrolled in the study during a regularly scheduled office visit …

  • 10 Mar, 2022
  • 14 locations
Development and Application of a Novel Digital Array PCR for Acute Myeloid Leukemia (AML)

Purpose: The purpose of this trial is to investigate whether a digital array assay can detect trace amounts of residual leukemia and predict relapse in acute myeloid leukemia (AML) patients in remission who have undergone allogeneic stem cell transplantation (SCT) at the North Carolina Cancer Hospital (NCCH). Participants: Adult patients …

cell transplantation
  • 29 Jun, 2022
  • 1 location