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Found 217 clinical trials
Phase I/II Trial of HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PD-L1/TGF-Beta Trap (M7824) in Subjects With HPV Positive Cancers

Background For some cancers associated with human papillomavirus (HPV), standard treatments are not helpful. Researchers want to see if a vaccine for HPV combined with a drug called M7824 has a better effect on these cancers than when they work alone. Objective To find a safe dose of HPV vaccine …

cancer
oropharyngeal carcinoma
human papilloma virus vaccine
antiretrovirals
human papillomavirus
  • 7 views
  • 27 Oct, 2022
  • 1 location
Avelumab With Binimetinib, Sacituzumab Govitecan, or Liposomal Doxorubicin in Treating Patients With Stage IV or Unresectable, Recurrent Triple Negative Breast Cancer (InCITe)

This phase II trial studies how well the combination of avelumab with liposomal doxorubicin with or without binimetinib, or the combination of avelumab with sacituzumab govitecan works in treating patients with triple negative breast cancer that is stage IV or is not able to be removed by surgery (unresectable) and …

epidermal growth factor receptor
progesterone receptor
tumor cells
triple negative breast cancer
monoclonal antibody therapy
  • 27 views
  • 17 Jun, 2022
  • 4 locations
Per-protocol Repeat Kidney Biopsy in Incident Cases of Lupus Nephritis (REBIOLUP)

Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Among people living with SLE, 35-60% will develop LN during the course of the disease. This complication is one of the factors that contribute to deterioration of the renal function. Some centres perform kidney biopsies …

treatment regimen
mycophenolate
kidney biopsy
nephritis
angiotensin receptor blockers
  • 0 views
  • 07 Jul, 2022
  • 1 location
Heterogeneously Hypofractionated Radiotherapy for Locally Advanced NSCLC

The options for patients with locally advanced non-small cell lung cancer (NSCLC) who are not candidates for a standard definitive chemoradiotherapy regime are meagre. These are patients who are not fit for a chemoradiotherapy schedule of 66 Gy in 2 Gy fractions due to either tumour extent, resulting in excessive …

  • 0 views
  • 04 Oct, 2022
  • 1 location
A LOW-INTERVENTIONAL, PROSPECTIVE, MULTI-CENTER STUDY TO EVALUATE REAL-WORLD CLINICAL, BIOCHEMICAL AND PATIENT-REPORTED RESPONSES TO TOFACITINIB INDUCTION THERAPY IN PATIENTS WITH MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS IN SWITZERLAND (KIC-START)

This study is expected to contribute to the body of real-world data of tofacitinib's safety and efficacy profile in ulcerative colitis. Conventional clinical outcomes will give a better understanding of response and remission rates in a representative, post-marketing population. Regular patient questionnaires and measurement of a biomarker of gut inflammation …

remission
  • 0 views
  • 22 Oct, 2022
  • 2 locations
Prediction Model for Response to Biologics and Small Molecular Agent for UC

This prospective observational study is going to develop and validate a prediction model of response to biologic agents and small molecular agents for Korean patients with ulcerative colitis.

vedolizumab
  • 0 views
  • 23 Mar, 2022
  • 1 location
Real-World Study on Long-term Treatment With YISAIPU for Fujian RA Patients (LORMYF)

Through real-world observation, understanding clinical efficacy and safety of treatment with YISAIPU (etanercept biosimilar) for RA patients of Fujian Province for three years

tumor necrosis factor inhibitors
sulfasalazine
hydroxychloroquine
leflunomide
methotrexate
  • 0 views
  • 08 Jul, 2022
  • 1 location
Observational Study on Skeletal Ewing's Sarcoma

Observational prospective trial aimed to collect the collect demographic, clinical, surgical, pathological and molecular characteristics and treatment from patients affected by skeletal Ewing Sarcoma

Accepts healthy volunteers
  • 2 views
  • 08 Nov, 2021
  • 16 locations
Minimal Invasive Axillary Staging and Treatment After Neoadjuvant Systemic Therapy in Node Positive Breast Cancer (MINIMAX)

Today, the majority of clinically node positive (cN+) breast cancer patients is treated with neoadjuvant systemic therapy (NST). Axillary staging and treatment after NST in cN+ patients are areas of controversy. Patients with a pathological complete response (pCR) of the axillary lymph nodes are not expected to benefit from axillary …

cancer
invasive breast cancer
axillary lymph node dissection
lymphadenectomy
systemic therapy
  • 12 views
  • 04 Oct, 2022
  • 35 locations
Efficacy and Safety of Lenalidomide With or Without Rituximab and Other Drugs in B-cell Non-Hodgkin's Lymphomas

Describe the treatment of B-cell non-Hodgkin lymphoma patients who receive lenalidomide single drug or lenalidomide combined with rituximab (with or without other drugs), and evaluate the efficacy and safety of lenalidomide single drug or lenalidomide combined with rituximab (with or without other drugs) in the real-world setting.

  • 0 views
  • 24 Jan, 2021