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Found 203 clinical trials
A Dose-escalating Pilot Study of Orelabrutinib for Newly-diagnosed PCNSL (ORMD2021)

This is a single arm, single center, open label pilot study of Orelabrutinib combined with Rituximab, high-dose (HD) Methotrexate and Dexamethasone in newly-diagnosed primary central nervous system lymphpoma (PCNSL). The purpose is to evaluate the safety and to find the optimal dose of Orelabrutinib and Methotrexate in this combination treatment …

  • 0 views
  • 04 Oct, 2022
  • 1 location
Venetoclax Plus Intensive Chemotherapy in AML and Advanced MDS

This phase Ib trial studies the best dose and side effects of venetoclax and how well it works when given with combination chemotherapy in treating patients with newly diagnosed acute myeloid leukemia or advanced myelodysplastic syndromes. Venetoclax may stop the growth of cancer cells by blocking some of the enzymes …

myelodysplastic syndromes
cancer
daunorubicin
myeloid leukemia
venetoclax
  • 0 views
  • 04 Oct, 2022
  • 1 location
Short Course Radiation Therapy Followed by Pre-operative Chemotherapy and Surgery in High-risk Rectal Cancer

Patients with a primary rectal cancer without detectable distant metastasis who after locoregional therapy only, meaning preoperative radio(chemo)therapy plus surgery have at least a 40% risk of not having a CRM negative resection or a recurrence, local or distant, within three years will be treated with the short course 5 …

oxaliplatin
capecitabine
metastasis
total mesorectal excision
adenocarcinoma
  • 3 views
  • 22 Jan, 2021
  • 1 location
Pembrolizumab, IRX-2, and Chemotherapy in Triple Negative Breast Cancer

This is a Phase II, randomized, open-label trial to evaluate the clinical and immunologic activity of pembrolizumab plus chemotherapy when combined with various immunotherapy induction regimens as neoadjuvant therapy for triple negative breast cancer (TNBC).

triple negative breast cancer
breast cancer staging
cyclophosphamide
inflammatory breast cancer
core needle biopsy
  • 0 views
  • 21 Mar, 2022
  • 1 location
A Study to Assess Safety, Tolerability and Preliminary Efficacy of Bexmarilimab in Combination With Standard of Care in Patients With Hematological Malignancies (BEXMAB)

This is a study to assess the safety of increasing dose levels of bexmarilimab when combined with standard of care (SoC) in patients with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) or acute myeloid leukemia (AML); Phase 1 aims to identify the recommended phase 2 dose (RP2D) of bexmarilimab …

azacitidine
myelomonocytic leukemia
myeloid leukemia
venetoclax
leukemia
  • 0 views
  • 04 Oct, 2022
  • 4 locations
Bendamustine + Obinutuzumab Induction Chemoimmunotherapy With Risk-adapted Obinutuzumab Maintenance Therapy in Previously Untreated Mantle Cell Lymphoma

This is a phase II single-arm, open-label, multicenter study evaluating the efficacy and safety of the combination of induction chemoimmunotherapy with bendamustine and obinutuzumab (BO) followed by consolidation therapy and maintenance therapy with obinutuzumab in subjects who have not received prior cytotoxic chemotherapy for their MCL (i.e., prior single agent …

mantle cell lymphoma
renal function tests
cancer
bendamustine
neutrophil count
  • 96 views
  • 13 Oct, 2022
  • 1 location
TITRATE (inducTIon for acuTe ulceRATivE Colitis) (TITRATE)

The aim of this study is to investigate whether intensive, personalized IFX dosing by using a pharmacokinetics driven dashboard system during the induction phase in patients with acute severe UC leads to increased treatment success (as defined by clinical and endoscopic response at week 6) as compared to the standard …

steroid therapy
endoscopy
intravenous steroids
infliximab
  • 3 views
  • 12 Feb, 2022
  • 1 location
LB-100, Carboplatin, Etoposide, and Atezolizumab for the Treatment of Untreated Extensive-Stage Small Cell Lung Cancer

This phase Ib trial studies the side effects and best dose of LB-100 when given together with carboplatin, etoposide, and atezolizumab for the treatment of untreated extensive-stage small cell lung cancer. Drugs such as carboplatin and etoposide work in different ways to stop the growth of tumor cells, either by …

  • 0 views
  • 10 Apr, 2022
  • 1 location
A Phase II, Open Label, Two-Arm Study of Therapeutic Iobenguane (131I) as Single Agent or in Combination With Vorinostat for Recurrent or Progressive High- Risk Neuroblastoma Subjects (OPTIMUM TRIAL) (OPTIMUM)

The purpose of this study is to evaluate the efficacy and safety of 131I-MIBG in combination with Vorinostat in patients with Recurrent or Progressive neuroblastoma

serum pregnancy test
neutrophil count
busulfan
mg++
carboplatin
  • 58 views
  • 25 Oct, 2022
  • 20 locations
KRDI in Transplant-Eligible MM

This research study is testing the efficacy of an experimental drug combination for people with newly diagnosed multiple myeloma that are eligible for a stem cell transplant. The names of the study drugs involved in this study are: Carfilzomib Isatuximab Lenalidomide Dexamethasone

serum calcium
neutrophil count
lenalidomide
calcium
bone marrow procedure
  • 0 views
  • 26 Apr, 2022