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Found 10 clinical trials
Incretin-mimetic Hypoglycemic Drugs and Severe Retinopathy (ANGIOSAFE2)

Experimental data suggest that GLP-1 promote endothelial cell growth and angiogenesis which may have beneficial effects on the cardiovascular system but harmful effects on the retina . This project investigate the possible link between incretin therapy and Severe Diabetic Retinopathy. The prevalence of severe DR in patients exposed to incretin …

retinopathy
incretins
glucagon-like peptide-1
antidiabetic agents
glucagon-like peptide 1
  • 0 views
  • 23 Feb, 2022
  • 1 location
GLP-1 and Hyperoxia for Organ Protection in Heart Surgery (GLORIOUS)

Patients undergoing open heart surgery are at risk of suffering damage to the heart, brain and kidneys. This study is designed as a 2-by-2 randomized clinical trial with the purpose of investigating the organ protective effects of the glucagon-like-peptide-1 (GLP-1) agonist Exenatide versus placebo and restrictive versus liberal oxygenation during …

heart disease
exenatide
byetta
bypass graft
heart surgery
  • 40 views
  • 27 Jan, 2022
  • 1 location
Effects of LIraglutide on CArdiac Steatosis Evaluated by Magnetic Resonance Imaging (LICAS-MR)

steatosis and epicardial fat, are altered in diabetic patients. The development of new anti-diabetics (incretins) has demonstrated protective cardiovascular effects independent of effects on glycemic

dyslipidemia
glucagon-like peptide-1
glucagon-like peptide 1
liraglutide
hypertension
  • 0 views
  • 07 Apr, 2022
  • 1 location
Beta-cell Response to Incretin Hormones in Cystic Fibrosis

In recent years, diabetes has emerged as one of the most significant co-diseases that many Cystic Fibrosis (CF) patients develop. Type 1 (T1D) and Type 2 (T2D) diabetes results when either the body does not make enough insulin or the body does not respond correctly to this insulin, respectively. Insulin …

pancreatic insufficiency
sweat test
Accepts healthy volunteers
insulin
fibrosis
  • 3 views
  • 26 May, 2022
  • 1 location
L-Cell Activity in Small Intestine as Biliopancreatic Loop in Obese Patients With DM2 Submitted to RYGBP

Prevalence of Obesity and its association with Diabetes Mellitus 2 (DM2) affect a significant percentage of the world's population with great socioeconomic impact, especially for developing countries. Several procedures and interventions are used in its treatment, and the most efficient and with a positive impact on the life of patients …

Accepts healthy volunteers
glucagon-like peptide-1
fasting
diabetes
bariatric surgery
  • 0 views
  • 25 Jul, 2022
  • 1 location
Acute Study of Polyphenol-rich Honeyberries, Cherries, and Raspberries Grown in Scotland on Postprandial Glycaemic Response

The purpose of this study is to determine if new varieties of fruits grown in Scotland which can adapt better to climate change namely, honeyberries and cherries, have the same health benefits as established fruits such as raspberries. To do this we will investigate the effects of consuming honeyberries, cherries, …

Accepts healthy volunteers
  • 0 views
  • 21 Sep, 2022
Therapeutic Targets in African-American Youth With Type 2 Diabetes

Background The pill metformin treats diabetes. But it does not work for all youth, especially African-Americans. The injectable Liraglutide treats type 2 diabetes in adults. Researchers want to understand how these drugs work and if they decrease excess sugar made by the liver in youth with type 2 diabetes. Objective …

sugars
continuous glucose monitoring
hemoglobin a1c
metformin
hypoglycemic agents
  • 9 views
  • 17 Sep, 2022
  • 1 location
Incretin Hormones in Type 1 Diabetes Mellitus;Effect of Metformin Treatment (INCREDIBLE-M)

Investigators aim is to conduct an RCT to study the effect of adjunct metformin treatment to insulin monotherapy in patients with type 1 diabetes, targeting the intestinal incretin secretion. The patients will be randomly allocated to metformin or placebo treatment for 4 months

diabetes
insulin
incretin
metformin
injection of insulin
  • 93 views
  • 27 Feb, 2022
  • 1 location
Genetics of Insulin and Incretins in Cystic Fibrosis

Type 2 Diabetes Mellitus (T2DM) mechanisms may be involved and may involve incretins (gut secreted hormones that augment insulin secretion in response to a nutrient load). This study will

diabetes
incretins
insulin
fibrosis
  • 7 views
  • 23 May, 2022
  • 2 locations
Long-term Health After Severe Acute Malnutrition in Children and Adults: the Role of the Pancreas (SAMPA)

Whilst there is an increasing prevalence of overweight and obesity worldwide, malnutrition remains common. In addition, malnutrition, overweight, and infections often interact. The consequences of malnutrition after birth are little studied. Severe acute malnutrition in childhood remains common in Africa and Asia and many adult patients with tuberculosis or HIV, …

Accepts healthy volunteers
sugars
  • 0 views
  • 14 May, 2022
  • 4 locations