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Found 66 clinical trials
Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients With Permanent Atrial Fibrillation (RAFT-PermAF)

Atrial fibrillation (AF) and heart failure (HF) are two common heart conditions that are encountered with an increase in death and suffering. When both these two conditions occur in a patient, the patient's prognosis is poor with a reduced quality of life and impaired heart function. These patients have enlarged …

permanent atrial fibrillation
left bundle branch block
sudden cardiac death
  • 11 Apr, 2022
  • 13 locations
Mutation-specific Therapy for the Long QT Syndrome

Novel therapy for the Long QT Syndrome based on the mechanism of action of the disease-causing mutations Long QT syndrome type 2 (LQT2) accounts for ~ 35% of all LQTS cases and is difficult to manage, as beta-blockers frequently fail to provide full protection. Most LQT2 patients (pts) have a …

atrial flutter
holter monitor
electrocardiographic monitoring
  • 01 Sep, 2021
  • 1 location
Sildenafil for Liver Fibrosis in Adolescents and Adults After Fontan Operation

Fontan operation is currently the most common procedure performed in patients with single-ventricle physiology. This surgery allows for passive caval blood flow to the pulmonary arteries in the absence of a subpulmonary pump and therefore separating the pulmonary circulation from systemic circulation. However, late hepatic complications such as liver fibrosis, …

hepatocellular carcinoma
venous pressure
  • 14 Jun, 2022
  • 1 location
Ventricular Tachycardia Ablation and Myocardial Scar Characterization With Magnetic Resonance

Previous monocentric experiences have already highlighted the role of preoperative cardiac imaging, in particular of cardiac magnetic resonance (CMR) and tomography (CT), in improving the ablation results of scar-related ventricular tachycardia (VT). A better characterization of scar obtained with high quality CMR images and post processing data with creation of …

  • 27 Jan, 2021
  • 7 locations
Ertugliflozin to Reduce Arrhythmic Burden in ICD/CRT patientS (ERASe-Trial) - a Phase III Study (ERASE)

The recent study is planned to investigate the impact of Ertugliflozin on total burden of ventricular arrhythmias. Further objectives will be number of therapeutic interventions of implanted devices, atrial fibrillation, heart failure biomarker and changes in physical function quality of life, stress and anxiety.

  • 25 Mar, 2022
  • 7 locations
The International SubcutaneouS Implantable Cardioverter Defibrillator Registry (iSuSI) (iSuSI)

The entirely subcutaneous implantable defibrillator (S-ICD) (Emblem, Boston Scientific, Marlborough, MA, USA) was introduced as a new therapeutic alternative to the conventional transvenous ICD in 2009 and implantations are rapidly expanding since then.1 Implantation of the S-ICD seems to reduce implant-related perioperative complications such as pneumothorax, hematoma and cardiac tamponade. …

  • 19 Jun, 2022
  • 1 location
The Correlation Between Gut Microbiome-host Interaction and Ventricular Arrhythmias.

This study will enroll 30 subjects recruited from the electrophysiology device clinic at the VA medical center. All patients will have a pre-existing implantable cardioverter defibrillator and a

Accepts healthy volunteers
  • 26 Nov, 2021
  • 1 location
Evaluation of the Improvement of Primary Prevention in Ischemic Cardiomyopathy Patients Using New Screening and Referring System (Advance-ICM)

The patients who undergo ICD(implantable cardioverter defibrillator) implantation for the primary prevention of sudden cardiac death with severe LV(left ventricle) dysfunction (ejection fraction

primary prevention
myocardial infarction
ejection fraction
implantable cardioverter-defibrillators
  • 05 Mar, 2022
Imaging Techniques for Identifying Factors of Sudden Cardiac Death Risk

Sudden cardiac death is a tragic event that strikes all age groups and is unfortunately increasing in prevalence. Because it is difficult to predict those at highest risk, this study is designed to test the hypothesis that new imaging techniques (magnetic resonance imaging [MRI] and computed tomography [CT]) are useful …

  • 04 Oct, 2022
  • 1 location
The ENVI Study: Effect of Entresto on Left Ventricular Remodelling on Cardiac MRI (ENVI)

A prospective, single centre, observational cohort study at University Hospital Southampton NHS Foundation Trust of 50 consecutive patients with Heart Failure with reduced Ejection Fraction and Ejection Fraction ≤35% who are eligible for sacubitril/valsartan (Entresto) initiation as per European Society of Cardiology guidelines. Participants will have baseline and repeat cardiac …

  • 10 May, 2022
  • 1 location