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Found 44 clinical trials
Safety and Tolerance of Epigenetic and Immunomodulating Drugs Combined With Chemotherapeutics in Patients Suffering From Advanced Pancreatic Cancer (SEPION)

A multi-center, open-label phase I/II study to to determine the safety and tolerability of Azacitidine and/or Romidepsin in combination with nab-Paclitaxel/Gemcitabine in patients with advanced pancreatic ductal adenocarcinoma (PDAC) (Part 1), followed by sequential immune targeting with programmed death-ligand (PD-L)1 blockade in combination with low-dose Lenalidomide (Part 2) in patients …

lenalidomide
antineoplastic
pdac
pancreatic ductal adenocarcinoma
paclitaxel
  • 0 views
  • 23 May, 2022
  • 9 locations
Safety Tolerability and Efficacy of Immunomodulation With AT-1501 in Islet Cell Transplantation

This study will evaluate the safety, tolerability and efficacy of AT-1501 in an immunomodulation regimen in adult patients with T1D undergoing an islet cell transplant.

treatment regimen
diabetes
hemoglobin a1c
immune tolerance
hypoglycemia
  • 0 views
  • 15 Sep, 2021
  • 1 location
Clinical Burden of Anemia in Inflammatory Bowel Disease: Therapeutic Trial

Anemia is the most common extraintestinal manifestation of inflammatory bowel diseases (IBD), Although most cases of anemia in IBD are due to iron deficiency, many patients with iron deficiency anemia (IDA) are not treated with iron supplementation. In addition, it has not been firmly established which iron supplementation modality provides …

enteropathy
fatigue
  • 0 views
  • 26 Jan, 2021
  • 1 location
Association of Adjuvant Radiotherapy of Non-metastatic Breast Carcinoma With Immunomodulation and Circulating Tumor Cell Phenotype in Relation to Patient Age.

In a prospective study, the influence of adjuvant radiotherapy in patients with non-metastatic breast carcinoma on the epithelial tumor cells (CETCs) circulating in the blood and their immunohistochemical characteristics depending on age will be investigated. In addition to a histopathological assignment of the CETCs as cells of the primary tumor, …

  • 0 views
  • 16 Oct, 2021
  • 1 location
Safety of IBD Drugs During Pregnancy and Breastfeeding: Mothers and Babies' Outcomes (DUMBO Registry)

This is a prospective, observational, multicenter registry, which will enrol pregnant women with IBD (CD, UC, or unclassified IBD) over 5 years in Spain. In addition, each incident gestation will be followed-up during pregnancy, and children born to those mothers will be followed-up over 4 years to determine the incidence …

  • 0 views
  • 27 Feb, 2022
  • 27 locations
The Sapienza University Mortality and Morbidity Events Rate (SUMMER) Study in Diabetes

This observational study is aimed at identifying new molecular promoters of mortality (and morbidity) in patients with type 2 diabetes mellitus (T2DM).

type 2 diabetes mellitus
  • 0 views
  • 09 Oct, 2021
  • 1 location
Evaluation of Reporting of Cardio-vascular Adverse Events With Antineoplastic and Immunomodulating Agents (EROCA) (EROCA)

Antineoplastic and immunomodulating agents may lead to various cardio-vascular adverse reactions. This study investigates reports of cardio-vascular toxicities for treatment including Anatomical Therapeutic Chemical (ATC) classification L (antineoplastic agents, endocrine therapy, immunostimulants, and immunosuppressants drugs) in the World Health Organization's (WHO) global database of individual safety case reports (VigiBase).

sudden cardiac death
endocrine therapy
antineoplastic agents
hormone therapy
immunosuppressive agents
  • 0 views
  • 03 Mar, 2022
Immunological Response to COVID-19 Vaccine in Patients With Autoimmune and Inflammatory Diseases Treated With Immunosuppressants and/or Biologics

treated with immunosuppressants or immunomodulators. Thus, the impact of treatments on the production of neutralizing antibodies and specific T lymphocytes is not known. The goal of this

rituximab
biologics
progressive systemic sclerosis
lupus
methotrexate
  • 0 views
  • 30 May, 2021
  • 1 location
Efficacy of COVID-19 Vaccination in Patients With Multiple Sclerosis Treated With Immune Modulating Medication

mRNA vaccination in patients with MS when compared to healthy controls not receiving immunomodulating medications. We hypothesize that the use of immunomodulators in MS patients may eliminate or

fingolimod
dimethyl fumarate
natalizumab
ocrelizumab
  • 0 views
  • 23 May, 2022
  • 1 location
The Effect of Methotrexate on Sperm Quality in Men With Inflammatory Bowel Disease

still completing schooling, establishing their career, and/or are building a family. Treatment options for IBD consist of immunosuppressive therapy, such as immunomodulators (azathioprine and

inflammatory disorder
mesalamine
crohn's disease
chronic disease
corticosteroids
  • 43 views
  • 21 Jul, 2021
  • 1 location