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Found 44 clinical trials
Ajuvant Chemotherapy and Immunotherapy in Patients With Esophageal Esophageal- Gastric Junction Cancer

Surgery with or without neoadjuvant therapy is usually used as the treatment for resectable esophageal cancer or esophageal- gastric junction cancer. Patients who have a poor response to neoadjuvant therapy and have an incomplete (R1) resection or have metastatic lymph nodes in the resection specimen (N+) are especially at risk …

  • 0 views
  • 28 Jan, 2021
  • 1 location
Strain vs. Left Ventricular Ejection Fraction-based Cardiotoxicity Prevention in Breast Cancer

Comparing preventive effect of myocardial global longitudinal strain-based cardioprotective stragety (angiotensin receptor blocker prophylaxis) with left ventricular ejection fraction-based strategy in breast cancer patients treated with adjuvant trastuzumab.

erbb2
strain
immunostimulant
angiotensin
HER2
  • 0 views
  • 25 Jan, 2021
  • 1 location
Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair

Open Abdominal Aortic Aneurysm (AAA) repair is a high-risk surgical procedure accompanied by intense endocrine and metabolic responses to surgical stress, with subsequent activation of the inflammatory cascade, cytokine and acute-phase protein release, and bone marrow activation. There is a proven correlation of surgical stress, which patients undergoing open AAA …

pain relieving
opioid
analgesia
dexamethasone
lidocaine
  • 0 views
  • 10 Nov, 2021
  • 1 location
Efficacy and Safety of EXOSOME-MSC Therapy to Reduce Hyper-inflammation In Moderate COVID-19 Patients (EXOMSC-COV19)

infected organs. On target immune cells, the anti-inflammatory cytokines work as immunomodulators to relieve hyper-inflammation. In infected cells, the miRNAs work to prevent viral replication by

  • 0 views
  • 26 Mar, 2022
Stereotaxic Body Irradiation of Oligometastase in Sarcoma (Stereosarc) (Stereosarc)

> Several potent immunomodulators that skew the tumor immune microenvironment toward a proimmunity context are being investigated in STS either alone or in combination with chemotherapy or targeted therapy

soft tissue sarcoma
leiomyosarcoma
liposarcoma
cancer chemotherapy
tumor cells
  • 0 views
  • 29 Jun, 2022
  • 1 location
Observation of the Efficacy of BAd Regimen in the Treatment of Relapsed and Refractory Multiple Myeloma

Observe the best dose, efficacy and adverse reactions of BAd in the treatment of relapsed and refractory multiple myeloma.

refractory multiple myeloma
dexamethasone
  • 0 views
  • 22 Aug, 2021
  • 1 location
Study of ISB 1342, a CD38/CD3 Bispecific Antibody, in Subjects With Previously Treated Multiple Myeloma

The purpose of this study is to assess safety, efficacy, pharmacokinetic (PK)/pharmacodynamic (PD), and immunogenicity with ISB 1342 in subjects with relapsed/refractory multiple myeloma.

monoclonal protein
monoclonal antibodies
measurable disease
refractory multiple myeloma
daratumumab
  • 59 views
  • 26 May, 2022
  • 17 locations
Fecal Microbiota Transplantation in Pediatric Crohn's Disease (FMT)

This study will test the safety and effectiveness of fecal microbiota transplantation (FMT) plus partial enteral nutrition (PEN) in refractory pediatric Crohn's disease (CD) who have failed conventional treatment

fecal microbiota transplantation
enteral nutrition
pediatric onset crohn's disease
microbiota
conventional treatment
  • 0 views
  • 06 May, 2022
  • 1 location
Isatuximab During Stem Cell Collection and Transplant in Patients With Multiple Myeloma and Lymphoma

The purpose of this study is to see if Isatuximab can alter the immune system in patients with multiple myeloma or lymphoma upon recovery from the autologous stem cell transplantation. The investigators will see if Isatuximab makes changes to the immune system so that upon recovery from the transplant, the …

multiple myeloma
hodgkin's disease
lymphoma
cancer
mantle cell lymphoma
  • 0 views
  • 12 May, 2022
  • 1 location
A Study to Evaluate Efficacy, of Early Versus Late Use of Vedolizumab in Crohn's Disease: the LOVE-CD Study (LOVE-CD)

This multi-centre open label study will involve a minimum of 260 patients in 2 cohorts: 86 patients with 'early CD' defined as disease duration < 24 months and no other treatments than corticosteroids and/or thiopurines and 174 patients with 'late CD' defined as active disease despite treatment with immunosuppressives and …

vedolizumab
ulceration
endoscopy
tumor necrosis factor
corticosteroids
  • 2 views
  • 26 Jan, 2022
  • 17 locations