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Found 41 clinical trials
A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Ulcerative Colitis (UC)

Vedolizumab is a medicine that helps to reduce inflammation and pain in the digestive system. In this study, children and teenagers with moderate to severe ulcerative colitis will be treated with vedolizumab. The main aim of the study is to check if participants achieve remission after treatment with vedolizumab. Remission …

corticosteroids
proctitis
adalimumab
methotrexate
hematochezia
  • 0 views
  • 07 Oct, 2022
  • 62 locations
Clinical Trial Using Humanized CART Directed Against BCMA (ARI0002h) in Patients With Relapsed/Refractory Multiple Myeloma to Proteasome Inhibitors, Immunomodulators and Anti-CD38 Antibody.

To assess the safety and efficacy of CARTBCMA ARI0002h in patients with relapsed/refractory multiple myeloma who have received treatment with proteasome inhibitor, immunomodulatory drug and anti-CD38 monoclonal antibody.

  • 5 views
  • 04 Oct, 2022
  • 6 locations
Laser vs Clobetasol for Lichen Sclerosus

topical steroids such as clobetasol, immunomodulators such as tacrolimus, and non-ablative laser treatment. Although both treatments are well documented and used in clinical practice, direct comparative

  • 6 views
  • 04 Oct, 2022
  • 1 location
the Prophylaxis of Recurrent Pouchitis After Fecal Microbiota Transplant in UC With Ileo-anal Anastomosis (POCA)

Ulcerative colitis (UC) is a chronic inflammatory digestive (IBD) disease medically treated with corticosteroids, aminosalicylates, immunomodulators, and biologics. Almost one third of UC

  • 0 views
  • 04 Oct, 2022
GM-CSF Fosfomycin and Metronidazole for Pouchitis in Ulcerative Colitis Patients After Restorative IPAA Surgery

This study will examine whether the application of GM-CSF, fosfomycin and metronidazole locally in the pouch is safe and effective in the treatment of pouchitis for patients with ulcerative colitis, and whether treatment changes the microbiome of the pouch.

  • 0 views
  • 20 Sep, 2021
  • 1 location
Synergetic B-cell Immunomodulation in SLE - 2nd Study. (SynBioSe-2)

In follow-up of the previous SynBioSe Study the present study is a randomized controlled trial designed to further investigate the long-term clinical and imunological efficacy of combination B-cell targeting by starting treatment with belimumab (anti-BAFF) followed by rituximab(anti-CD20) in lupus nephritis patients.

belimumab
immunosuppressive agents
anti-dna antibodies
myositis
baff
  • 28 views
  • 27 Apr, 2022
  • 4 locations
Immunomodulation With Eltrombopag in ITP (iROM2)

The study aims to investigate immunomodulatory effects of eltrombopag combined with dexamethasone in young and midlife adult patients with newly diagnosed primary Immune thrombocytopenia (ITP).

  • 0 views
  • 07 Oct, 2022
  • 6 locations
A Phase 2b Dose Ranging Study to Evaluate the Efficacy and Safety of Rozibafusp Alfa (AMG 570) in Subjects With Active Systemic Lupus Erythematosus (SLE) With Inadequate Response to Standard of Care (SOC) Therapy

The purpose of this study is to determine if Rozibafusp Alfa could be a useful therapeutic agent in the current treatment landscape where subjects with SLE have ongoing disease activity despite treatment with standard of care therapies.

methotrexate
hydroxychloroquine
nephritis
mycophenolate
antinuclear antibody
  • 101 views
  • 10 Oct, 2022
  • 125 locations
A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)

Vedolizumab is a medicine that helps to reduce inflammation and pain in the digestive system. In this study, children and teenagers with moderate to severe Crohn's disease will be treated with vedolizumab. The main aim of the study is to check if participants achieve remission after treatment with the vedolizumab. …

corticosteroids
adalimumab
crohn's disease
methotrexate
infliximab
  • 0 views
  • 07 Oct, 2022
  • 41 locations
In Vitro Immunomodulation in Membranous Nephropathy Relapses (BIOGEM)

immunomodulators on the Th17/Treg balance, assessed by cytokine profile and lymphocyte phenotyping using flow cytometry.

proteinuria
remission
nephropathy
  • 0 views
  • 11 Jul, 2022
  • 1 location