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Found 42 clinical trials
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COVID-19 Treatment Trial: Investigational Medication as a Non-antiviral Immunomodulator

The study is designed to compare two COVID-19 treatment regimens in hospitalized adult subjects who are diagnosed with severe COVID 19.  The investigational medication is called CD24Fc. Participants will be randomly assigned to one of two treatment "arms" for the study and neither the participant, nor the study team will …

  • 3991 views
  • 17 Jun, 2020
  • 4 locations
Proof -of -Concept Study To Stratify Targeted Therapies Adapted To Molecular Profiling

profile and possible response to treatment, methylation array, miRNA expression profiles, and study of immunomodulators will be performed on tumor samples subsequently. CLIP2 (INCa-labeled early phase

  • 39 views
  • 23 Jan, 2021
  • 5 locations
Clinical Trial Using Humanized CART Directed Against BCMA (ARI0002h) in Patients With Relapsed/Refractory Multiple Myeloma to Proteasome Inhibitors Immunomodulators and Anti-CD38 Antibody.

To assess the safety and efficacy of CARTBCMA ARI0002h in patients with relapsed/refractory multiple myeloma who have received treatment with proteasome inhibitor, immunomodulatory drug and anti-CD38 monoclonal antibody.

  • 0 views
  • 26 Jan, 2021
  • 5 locations
Intralesional Triamcinolone Acetonide and Its Combination With 5-fluorouracil in Keloids and Hypertrophic Scars

, cryotherapy, lasers, antineoplastic agents (5-FU, mitomycin-C), surgical excision and immunomodulators (imiquimod) used either as monotherapy or combination therapy. Different studies involving combination of

  • 0 views
  • 31 Mar, 2021
  • 1 location
the Prophylaxis of Recurrent Pouchitis After Fecal Microbiota Transplant in UC With Ileo-anal Anastomosis

Ulcerative colitis (UC) is a chronic inflammatory digestive (IBD) disease medically treated with corticosteroids, aminosalicylates, immunomodulators, and biologics. Almost one third of UC

  • 0 views
  • 23 Jan, 2021
  • 10 locations
Safety and Tolerance of Immunomodulating Therapy With Donor-specific MSC in Pediatric Living-Donor Liver Transplantation

Since the introduction of calcineurin-based immunosuppression, patient and graft survival in pediatric liver transplantation (LT) improved significantly. However, in contrast, calcineurin inhibitor (CNI) toxicity leads to significant morbidity and impairs quality of life for recipients. Moreover, CNI cannot prevent long-term allograft inflammation and fibrosis. Mesenchymal stem (stromal) cells (MSC) have …

  • 9 views
  • 22 Jan, 2021
  • 1 location
Synergetic B-cell Immunomodulation in SLE - 2nd Study.

In follow-up of the previous SynBioSe Study the present study is a randomized controlled trial designed to further investigate the long-term clinical and imunological efficacy of combination B-cell targeting by starting treatment with belimumab (anti-BAFF) followed by rituximab(anti-CD20) in lupus nephritis patients.

pericarditis
nephritis
anti-dna antibodies
mycophenolate
elisa
  • 10 views
  • 07 Mar, 2021
  • 4 locations
Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE)

The purpose of this study is to determine if Rozibafusp Alfa could be a useful therapeutic agent in the current treatment landscape where subjects with systemic lupus erythematosus (SLE) have ongoing disease activity despite treatment with standard of care therapies.

pericarditis
nephritis
mouth ulcer
methotrexate
rheumatism
  • 44 views
  • 23 Jun, 2021
  • 231 locations
A Study of Ustekinumab in Participants With Active Polymyositis and Dermatomyositis Who Have Not Adequately Responded to One or More Standard-of-care Treatments

(for example, glucocorticoids and/or immunomodulators).

glucocorticoids
aldolase
weakness
methotrexate
creatine kinase
  • 8 views
  • 25 Mar, 2021
  • 38 locations
Ajuvant Chemotherapy and Immunotherapy in Patients With Esophageal Esophageal- Gastric Junction Cancer

Surgery with or without neoadjuvant therapy is usually used as the treatment for resectable esophageal cancer or esophageal- gastric junction cancer. Patients who have a poor response to neoadjuvant therapy and have an incomplete (R1) resection or have metastatic lymph nodes in the resection specimen (N+) are especially at risk …

  • 0 views
  • 28 Jan, 2021
  • 1 location