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Found 47 clinical trials
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COVID-19 Treatment Trial: Investigational Medication as a Non-antiviral Immunomodulator

The study is designed to compare two COVID-19 treatment regimens in hospitalized adult subjects who are diagnosed with severe COVID 19.  The investigational medication is called CD24Fc. Participants will be randomly assigned to one of two treatment "arms" for the study and neither the participant, nor the study team will …

  • 3989 views
  • 17 Jun, 2020
  • 4 locations
Proof -of -Concept Study To Stratify Targeted Therapies Adapted To Molecular Profiling

profile and possible response to treatment, methylation array, miRNA expression profiles, and study of immunomodulators will be performed on tumor samples subsequently. CLIP2 (INCa-labeled early phase

  • 39 views
  • 23 Feb, 2020
  • 5 locations
Clinical Trial Using Humanized CART Directed Against BCMA (ARI0002h) in Patients With Relapsed/Refractory Multiple Myeloma to Proteasome Inhibitors Immunomodulators and Anti-CD38 Antibody.

To assess the safety and efficacy of CARTBCMA ARI0002h in patients with relapsed/refractory multiple myeloma who have received treatment with proteasome inhibitor, immunomodulatory drug and anti-CD38 monoclonal antibody.

  • 0 views
  • 08 Oct, 2020
  • 5 locations
Preoperative Nutrition With Immune Enhancing Nutritional Supplement (Immunomodulation)

The purpose of this study is to determine the optimal effective dose for preoperative nutritional supplementation with immunomodulators on immune function and perioperative outcomes following

immunomodulators
pdac
  • 0 views
  • 08 Nov, 2020
  • 1 location
the Prophylaxis of Recurrent Pouchitis After Fecal Microbiota Transplant in UC With Ileo-anal Anastomosis

Ulcerative colitis (UC) is a chronic inflammatory digestive (IBD) disease medically treated with corticosteroids, aminosalicylates, immunomodulators, and biologics. Almost one third of UC

  • 0 views
  • 08 Nov, 2020
Haploidentical Bone Marrow Stem Cell Transplantation in Patients With Multiple Myeloma

The aim of this phase 2 study is to demonstrate that KIR-ligand mismatched haploBMT with post-transplant cyclophosphamide will improve progression free survival in poor risk multiple myeloma patients.

cyclophosphamide
bone marrow procedure
measurable disease
cell transplantation
  • 29 views
  • 08 Nov, 2020
  • 1 location
Gum Arabic as Immunomodulator In Rheumatoid Arthritis Patients

Gum Arabic (GA) rich dietary fiber it is a water-soluble dietary fiber derived from the dried gummy exudates of the stems and branches of Acacia senegal, GA found to have strong immuno modulator in vitro where it increased IL10 production showing strong anti-inflammatory effects (19). The aim of this study …

  • 54 views
  • 08 Nov, 2020
  • 1 location
Synergetic B-cell Immunomodulation in SLE - 2nd Study.

In follow-up of the previous SynBioSe Study the present study is a randomized controlled trial to assess the potential of the new therapeutic approach in lupus nephritis patients. The hypothesis is that by starting therapy with belimumab (anti-BAFF), migration of tissue residing B-cells is obtained before treatment with rituximab (anti-CD20) …

rituximab
anti-dna antibodies
azathioprine
vasculitis
pericarditis
  • 10 views
  • 08 Nov, 2020
  • 1 location
SBRT + Immunomodulating Systemic Therapy for Inoperable Recurrent H&N

To derive the maximum tolerated dose of hypofractionated stereotactic body radiotherapy (SBRT) using dose painting by numbers with immunomodulating systemic therapy in patients that are reirradiated for recurrent squamous cell carcinoma of the head and neck.

neck cancer
nivolumab
dental caries
cancer
mouth cancer
  • 3 views
  • 08 Nov, 2020
  • 1 location
Safety and Tolerance of Immunomodulating Therapy With Donor-specific MSC in Pediatric Living-Donor Liver Transplantation

Since the introduction of calcineurin-based immunosuppression, patient and graft survival in pediatric liver transplantation (LT) improved significantly. However, in contrast, calcineurin inhibitor (CNI) toxicity leads to significant morbidity and impairs quality of life for recipients. Moreover, CNI cannot prevent long-term allograft inflammation and fibrosis. Mesenchymal stem (stromal) cells (MSC) have …

  • 9 views
  • 08 Nov, 2020
  • 1 location