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Found 38 clinical trials
Multi Peptide Vaccination With XS15 in Addition to Standard Postoperative Radiation Therapy and Temozolomide Chemotherapy in Newly Diagnosed Glioblastoma (GLIO-XS15)

Newly diagnosed HLA-A2-positive MGMT-methylated glioblastoma patients will be vaccinated with a Multi peptide vaccination with Pam3Cys-GDPKHPKSF (XS15) as an immunomodulator in addition to

  • 26 May, 2022
  • 1 location
Pegloticase and Methotrexate Co-administered in Patients With Uncontrolled Gout Who Have Previously Failed Pegloticase Monotherapy

concomitant immunomodulator and stopped pegloticase due to failure to maintain sUA (serum uric acid) response and/or a clinically mild IR (infusion reaction). Approximately 30 participants will be enrolled

  • 24 Mar, 2022
  • 15 locations
Phase I Study of AZD5363 + Olaparib + Durvalumab in Patients With Advanced or Metastatic Solid Tumor Malignancies

microenvironment in regulation of intratumoral immune regulators (i.e. T-regulatory cells) in improving response to Durvalumab To understand the role of AZD5363 as an immunomodulator To evaluate

  • 22 Jan, 2021
  • 1 location
Duvelisib in Combination With Nivolumab in Patients With Advanced Unresectable Melanoma

This trial is a Phase I/II study in which a combination of duvelisib and nivolumab will be used to treat a total of patients diagnosed with advanced unresectable melanoma who have progressed on anti-PD1 therapy. The Recommended Phase II Dose of oral duvelisib will be determined and administered with intravenous …

  • 03 May, 2022
  • 1 location
Synergetic B-cell Immunomodulation in SLE - 2nd Study. (SynBioSe-2)

In follow-up of the previous SynBioSe Study the present study is a randomized controlled trial designed to further investigate the long-term clinical and imunological efficacy of combination B-cell targeting by starting treatment with belimumab (anti-BAFF) followed by rituximab(anti-CD20) in lupus nephritis patients.

anti-dna antibodies
  • 27 Apr, 2022
  • 4 locations
Immunomodulation With Eltrombopag in ITP (iROM2)

The study aims to investigate immunomodulatory effects of eltrombopag combined with dexamethasone in young and midlife adult patients with newly diagnosed primary Immune thrombocytopenia (ITP).

  • 07 Oct, 2022
  • 6 locations
Clinical Trial Using Humanized CART Directed Against BCMA (ARI0002h) in Patients With Relapsed/Refractory Multiple Myeloma to Proteasome Inhibitors, Immunomodulators and Anti-CD38 Antibody.

To assess the safety and efficacy of CARTBCMA ARI0002h in patients with relapsed/refractory multiple myeloma who have received treatment with proteasome inhibitor, immunomodulatory drug and anti-CD38 monoclonal antibody.

  • 04 Oct, 2022
  • 6 locations
Single-center, Open-label, Single-arm Exploratory Clinical Trial of Anlotinib Monotherapy and Combination Therapy in Relapsed / Refractory MM Previously Treated With Immunomodulator and Protease Inhibitor Regimens

This is a Single-center, Open-label, Single-arm Exploratory Clinical Study to evaluate the safety and efficacy of Anlotinib Hydrochloride Capsule Monotherapy and Combination Therapy in relapsed or refractory multiple myeloma patient.

  • 18 Oct, 2022
  • 1 location
Molecular Effects of Apremilast in the Synovium of Psoriatic Arthritis Patients

This study assess the genomics profiles in synovial biopsies obtained prior to, and 24 weeks after an immunomodulator agent (Apremilast) in patients with active psoriatic arthritis who are naive

  • 27 Jan, 2021
  • 1 location
Vitamin D and Pre Cachexia and Cancer Cachexia in Epithelial Ovarian Cancer (VitD)

Several ex vivo, in vitro, and observational studies on various type of cancer shown positive effect of vitamin D. Vitamin D has widely known as immunomodulator property in various diseases

  • 09 Jul, 2022
  • 2 locations