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Found 215 clinical trials
Testing the Response to the Anti-cancer Drug, Triapine, in Uterine Cancers Using Markers From the Tissue at the Time of Hysterectomy

This early phase I trial investigates the response of the anti-cancer drug, triapine, in uterine cancers by using markers from tissue samples at the time of removal of the uterus, ovaries, and fallopian tubes (hysterectomy and bilateral salpingo-oophorectomy). Triapine may stop the growth of tumor cells by blocking some of …

  • 0 views
  • 19 Jun, 2022
  • 1 location
A Dose-escalation, Expansion Study of ARX788, in Advanced Solid Tumors Subjects With HER2 Expression (ACE-Pan Tumor 01)

This 2-part, Phase 1, open-label study will determine the recommended Phase 2 dose (RP2D) of ARX788 in subjects with advanced HER2 positive cancers and will assess the safety and anticancer activity in breast, gastric and other advanced HER2 positive solid tumors.

erbb2
lapatinib
advanced breast cancer
ejection fraction
renal function
  • 16 views
  • 01 Mar, 2022
  • 9 locations
Immune Induction Strategies to Improve Response to Immune Checkpoint Blockade in Triple Negative Breast Cancer (TNBC) Patients (TONIC-2)

This is a single center non-blinded randomized multi-cohort non-comparative phase II trial with a Simon's two-stage design.

metastasis
anthracyclines
breast cancer
brain metastases
triple negative breast cancer
  • 0 views
  • 09 Apr, 2022
  • 1 location
An Assessment of TLR4 and TOPK/PRPK Signaling in Sun Damaged Human Skin Acutely Exposed to Solar Simulated Light

The purpose of this project is to obtain clinical data, including skin samples, that will help investigators evaluate changes occurring in sun damaged human skin as a result of light that simulates sun exposure (Solar Simulated Light). Of specific interest are the molecular targets for cancer prevention. Molecular targets are …

Accepts healthy volunteers
  • 0 views
  • 20 Jun, 2022
  • 1 location
A Study of RC48-ADC for the Treatment of Locally Advanced or Metastatic Breast Cancer With Low Expression of HER2

This study will compare RC48-ADC to physician choice standard treatment. Participants must have HER2-low breast cancer previous use of anthracyclines, and have been treated with one or two systemic chemotherapy regimens following recurrence/metastasis.

erbb2
metastasis
endocrine therapy
anthracyclines
measurable disease
  • 0 views
  • 01 Dec, 2021
  • 1 location
Hybrid Molecular Imaging of ER in Breast Cancer Patients With DCIS

This prospective, one-arm study which will enroll participants with biopsy-proven DCIS scheduled for diagnostic breast MRI for preoperative staging/extent of disease evaluation as part of standard of care. Eligible participants will be consented for participation in the research study which includes a directed breast PET/MRI with 18F-FES. 18F-FES uptake of …

magnetic resonance imaging of breast
estrogen
ductal carcinoma in situ
  • 4 views
  • 18 Feb, 2022
  • 1 location
Pemetrexed and Pembrolizumab for the Treatment of Recurrent and/or Metastatic Salivary Gland Cancer

This phase II trial studies the effect of pemetrexed and pembrolizumab in treating patients with salivary gland cancer that has come back (recurrent) and/or has spread to other places in the body (metastatic). Chemotherapy drugs, such as pemetrexed, work in different ways to stop the growth of tumor cells, either …

  • 0 views
  • 07 Apr, 2022
  • 3 locations
Evaluation of 18F-fluciclovine (FACBC) PET/MR Uptake in Participants With Glioma (FACBC)

This is a pilot study to assess the ability of [F-18]fluciclovine to differentiate pseudoprogression from progression in participants after therapy, at imaging time points within the 12 week interval post chemoradiation. [F-18]fluciclovine. PET will be obtained at the time point in the 12 week interval in which MRI demonstrates increase …

chemoradiotherapy
MRI
tumor progression
  • 0 views
  • 22 Mar, 2022
  • 1 location
Imaging of Pathologic Fibrosis Using 68Ga-FAP-2286

This is a single arm prospective pilot trial that evaluates the ability of a novel imaging agent (68Ga-FAP-2286) to identify pathologic fibrosis in the setting of hepatic, cardiac and pulmonary fibrosis. FAP-2286 is a peptide that potently and selectively binds to Fibroblast Activation Protein (FAP). FAP is a transmembrane protein …

hepatic fibrosis
idiopathic pulmonary fibrosis
sarcoidosis
pulmonary fibrosis
fibrosis
  • 0 views
  • 25 Mar, 2022
  • 1 location
Simultaneous Multinuclear Metabolic MRI in Newly Diagnosed or Recurrent Glioma

This clinical trial constructs and tests a novel multinuclear metabolic magnetic resonance imaging (MRI) sequence in patients with glioma (brain tumor) that is newly diagnosed or has come back (recurrent). This trial aims to develop new diagnostic imaging technology that may bridge gaps between early detection and diagnosis, prognosis, and …

recurrent glioma
brain tumor
cancer
Accepts healthy volunteers
MRI
  • 0 views
  • 07 Oct, 2021
  • 1 location