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Found 216 clinical trials
Study of the Response to Irradiation on Prostatic Explants ex Vivo, as a Predictive Factor of the Clinical Response to Irradiation of Prostate Cancers (EXPLANT)

(immunohistochemistry) to irradiation on ex vivo prostate explants. These explants will be irradiated after culture and the transcriptional and immunohistochemical changes analysed before and after irradiation to

endocrine therapy
adenocarcinoma of prostate
adenocarcinoma
hormone therapy
  • 0 views
  • 28 Apr, 2022
  • 1 location
Ovarian Cancer Treatment With a Liposome Formulated mRNA Vaccine in Combination With (Neo-)Adjuvant Chemotherapy (OLIVIA)

surgery. [18F]FB-IL2 PET-CT will be used for the non-invasive assessment of T-cell activation and correlated to immunohistochemistry tumor tissue data from pre-treatment biopsy and interval debulking

paclitaxel
cancer of the ovary
ascites
tumor debulking
immunostimulant
  • 2 views
  • 19 Feb, 2022
  • 1 location
A Phase Ib Safety lead-in, Followed by Phase II Trial of ADG106 in Combination With Neoadjuvant Chemotherapy in HER2 Negative Breast Cancer

immunohistochemistry in HER2 negative breast cancer after treatment with ADG106 alone and in combination with chemotherapy. Secondary Objectives To determine the efficacy of combination of

  • 0 views
  • 02 Jul, 2022
  • 1 location
Combination of Atezolizumab With Dendritic Cell Vaccine in Patients With Lung Cancer

) and Overall response rate (ORR) The translational substudy will include: Analysis of tumor tissue samples will consist of PD-L1 Immunohistochemistry testing, RNA expression, Work

  • 0 views
  • 14 Jul, 2021
  • 3 locations
Feasibility of IV Tc-99m-tilmanocept for Imaging of M2-like TAMs in Metastatic Melanoma (Tilmanocept)

will be compared to immunohistochemistry results from biopsy staining for TAMs and M2-like TAMs and retrospectively with response to the immunotherapy to determine any correlation between M2-like TAMs

advanced melanoma
metastatic melanoma
  • 0 views
  • 27 Jun, 2022
  • 1 location
Impact of Neoadjuvant Immunotherapy in Early Stage Breast Cancer Before Standard Therapy (BIS-Program)

The aim of this study is to determine, using immunohistochemistry (IHC) on biopsies and surgically removed tumor if short-treatment immunotherapy with atezolizumab monotherapy or in combination

female breast cancer
pertuzumab
trastuzumab
HER2
immunohistochemistry
  • 0 views
  • 14 Apr, 2022
  • 1 location
HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

or young adult with a refractory or recurrent CNS tumor will have their tumor tested for HER2 expression by immunohistochemistry (IHC) at their home institution or at Seattle Children's Hospital. If

cancer chemotherapy
cns disease
apheresis
central nervous system tumor
erbb2
  • 68 views
  • 17 Mar, 2022
  • 1 location
Preoperative Chemoradiotherapy With CApecitabine and Temozolomide in MGMT Silenced, MSS, Locally Advanced RecTal Cancer (CATARTIC)

-methylated pretreated metastatic colorectal cancer and responses are restricted to tumors with complete MGMT loss by immunohistochemistry (IHC) and microsatellite stable (MSS) status. Both

fluorouracil
chemo-radiotherapy
adenocarcinoma
chemoradiotherapy
oxaliplatin
  • 0 views
  • 24 Mar, 2022
  • 1 location
Single-center Pathophysiological Study of the Role of Inflammation, Changes in the Intestinal Epithelial Barrier and the Intestinal Microbiota in Parkinson's Disease (IBIM-Park)

phosphorylated alpha-synuclein will be evaluated by immunohistochemistry. All of these parameters will be correlated with clinical data on the severity of PD: duration of development, age, total Unified

alpha-synuclein
Accepts healthy volunteers
  • 0 views
  • 24 Mar, 2022
  • 1 location
Chemotherapy and Immunotherapy as Treatment for MSS Metastatic Colorectal Cancer With High Immune Infiltrate (POCHI)

tissue and adjacent non-tumour tissue will be analysed using two techniques : immunoscore® and TuLIS score.It consist in Immunohistochemistry with CD3 and CD8 staining. Slides will be scanned and

  • 0 views
  • 07 Apr, 2022
  • 25 locations