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Found 218 clinical trials
Complement C5a Receptors in Hidradenitis Suppurativa

To study the role of C5a in Hidradenitis Suppurativa (HS). Complement C5a is a major chemotactic factor that stimulates neutrophil infiltration.

hidradenitis
Accepts healthy volunteers
  • 209 views
  • 25 Feb, 2022
  • 1 location
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH

Pulmonary arterial hypertension (PAH) is characterized by the progressive increase in pulmonary vascular resistance ultimately leading to right ventricular (RV) failure. Its prevalence is estimated at 40-60 persons per million and predominantly affects people between 20 and 60 years of age. Newly available therapies have improved the 3-year survival to …

hypertension
  • 0 views
  • 20 Apr, 2022
  • 1 location
Genomic and Phenotypic Determinants of Resistance to Immunotherapies in Multiple Myeloma

A total of 40 Multiple Myeloma (MM) patients at clinical relapse who progressed during Proteasome Inhibitors (PIs) or Immunomodulating Drugs (IMiDs)-based therapies and who are assigned to antiCD38-based salvage treatments, will be enrolled. We will collect bone marrow (BM) and peripheral blood (PB) samples from patients at specific timepoints: baseline …

  • 0 views
  • 25 May, 2022
  • 1 location
Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly

Cognitive disorders increase with age and in the presence of metabolic diseases such as Type 2 Diabetes Mellitus (T2DM). In addition, digestive disorders, changes in dietary pattern and decreased activity negatively influence the microbiome. The hypothesis is that pharmacological intervention with metformin will modify the composition of the gut microbiota …

type 2 diabetes mellitus
continuous glucose monitoring
metformin
  • 0 views
  • 30 May, 2021
  • 1 location
Prediction of Aortic Dilatation and Rupture

Aortic aneurysm is a very common incidental finding in the diagnostic imaging of the chest. It is especially common in middle aged men (up to 40 %). It is called as a silent killer, since it can lead to aortic dissection and rupture without pre-existing symptoms. Mortality of rupture can …

  • 0 views
  • 10 Oct, 2021
  • 1 location
Multiomic Approach to Radioresistance of Ependymomas in Children and Adolescents

Treatment of childhood ependymoma, the second most frequent pediatric brain tumor, is based on surgery and radiation therapy. However, 50% relapse, mainly locally. Progress in imaging, molecular biology and radiotherapy ballistics has led us to propose the EPENDYMOMICS project, a multi-omics approach using artificial intelligence to detect the predictive characteristics …

  • 0 views
  • 16 Dec, 2021
  • 1 location
The Carotid Artery Multi-modality Imaging Prognostic (CAMP) Study

Carotid artery disease is a main cause of ischemic stroke and vascular dementia, and a highly prevalent disease. There is uncertainty about the optimal management of patients with serendipitously or systematically detected asymptomatic carotid artery disease, due to the paucity of information on the predictive features of serious vascular events. …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Efficacy of Mepolizumab in Severe Asthmatics (MESILICO)

Interleukin (IL)-5 is the main cytokine responsible for the activation of eosinophils, hence therapeutic strategies have been investigated and developed for clinical use. Biologics targeting IL-5 and its receptor (first mepolizumab and subsequently, reslizumab and benralizumab), have been recently approved and used as add-on therapy for severe eosinophilic asthma resulting …

  • 0 views
  • 30 Jan, 2021
  • 1 location