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Found 239 clinical trials
Tarceva Italian Lung Optimization tRial

The aim of this study is to assess the superiority of docetaxel in comparison to erlotinib in second line in wild-type EGFR tumour patients.

docetaxel
erlotinib
EGFR
tarceva
  • 39 views
  • 07 Nov, 2020
  • 47 locations
Trastuzumab Deruxtecan in Participants With HER2-overexpressing Advanced or Metastatic Colorectal Cancer

This study will evaluate the efficacy, safety, and pharmacokinetics of Trastuzumab deruxtecan (T-DXd) in participants with human epidermal growth factor 2 (HER2)-overexpressing locally advanced, unresectable, or metastatic colorectal cancer (mCRC).

  • 0 views
  • 14 Jun, 2021
  • 66 locations
FFNP-PET/MR Imaging of Progesterone Receptor Expression in Invasive Breast Cancer

breast cancer. The hypothesis is that FFNP SUVmax from PET/MRI will correlate well against the semi-quantitative PR immunohistochemistry score.

immunohistochemistry
progesterone receptor
progesterone
  • 0 views
  • 04 Apr, 2021
  • 1 location
Phase II Study of RAD001 in a Neoadjuvant Setting in Men With Intermediate or High Risk Prostate Cancer

will be admitted to 6 weeks treatment with RAD001 10 mg/day followed by either radical prostatectomy or radiotherapy combined with hormonal treatment. Immunohistochemistry with antibodies

castration-resistant prostate cancer
adenocarcinoma
adenocarcinoma of prostate
prostatectomy
PTEN
  • 3 views
  • 07 Nov, 2020
  • 1 location
The Effect of Allergen Immunotherapy on Anti-viral Immunity in Patients With Allergic Asthma

epithelial cells as the primary outcome. Secondary outcomes such as: Inflammatory cytokines, immunologic phenotype and immunohistochemistry will be investigated in bronchial biopsies, blood, bronchoalveolar

  • 1 views
  • 25 Jan, 2021
  • 1 location
Atezolizumab and BCG in High Risk BCG na ve Non-muscle Invasive Bladder Cancer (NMIBC) Patients (BladderGATE)

-specific CD8 T-cells, impairing cytokine production and diminishing the toxicity of activated T-cells. PD-L1 expression by immunohistochemistry using the Ventana SP142 assay on tumor-infiltrating immune

bladder cancer
transurethral resection
tumor cells
expression by immunohistochemistry
carcinoma of the bladder
  • 0 views
  • 25 Jan, 2021
Cladribine With Simultaneous or Delayed Rituximab to Treat Hairy Cell Leukemia

antibody dependent cytotoxicity (ADCC or CDC). Patients in complete remission (CR) to cladribine have minimal residual disease (MRD) by immunohistochemistry of the bone marrow biopsy (BMBx IHC), a

  • 38 views
  • 13 Jun, 2021
  • 1 location
A Study Investigating DNA-damage Response Agents in Molecularly Altered Advanced Cancer

The study is investigating efficacy, safety and tolerability of DNA-damage Response Agents (or Combinations), in participants with advanced/metastatic solid malignancies whose tumours contain molecular alterations.

  • 0 views
  • 31 May, 2021
  • 23 locations
Lenalidomide Combined With R-CHOP(R2-CHOP) in Newly Diagnosed Double-expressor Diffuse Large B-Cell Lymphoma Patients

In this phase II study, the investigators are aiming to explore lenalidomide combined with R-CHOP (R2-CHOP) in newly diagnosed double-expressor Diffuse Large B-Cell Lymphoma patients (DLBCL)

  • 1 views
  • 23 Jan, 2021
  • 1 location
Duct Endoscopy in Assessing Cellular Atypia in the Breast Duct Fluid of Women With a Genetic Risk for Breast Cancer

RATIONALE: Diagnostic procedures, such as breast duct endoscopy, may improve the ability to detect breast cancer earlier and plan more effective treatment. PURPOSE: This phase II trial is studying how well breast duct endoscopy works in assessing cellular atypia (abnormal cells) in the breast ducts of women with a genetic …

immunohistochemistry
  • 0 views
  • 07 Nov, 2020
  • 1 location