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Found 81 clinical trials
Elotuzumab in Immunoglobulin G4-Related Disease (IgG4-RD)

This is a two-part multi-center clinical trial in participants with active IgG4-RD. Part 1 (Cohort 1a and Cohort 1B) is an open-label, dose escalation phase to determine the safety of elotuzumab for investigation in IgG4-RD. Part 2 (Cohort 2) is a randomized, placebo-controlled, double-blinded (masked) trial phase to compare the …

  • 0 views
  • 28 Jun, 2022
  • 1 location
Study of Kappa Chimeric Antigen Receptor (CAR) T Lymphocytes Co-Expressing the Kappa and CD28 CARs for Relapsed/Refractory Kappa+ Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.

This study will combine both T cells and antibodies in order to create a more effective treatment. The treatment tested in this study uses modified T-cells called Autologous T Lymphocyte Chimeric Antigen Receptor (ATLCAR) cells targeted against the kappa light chain antibody on cancer cells. For this study, the anti-kappa …

cancer
lymphocytic leukemia
chronic lymphocytic leukemia
refractory follicular lymphoma
bendamustine
  • 15 views
  • 09 Dec, 2021
  • 1 location
A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients

This is a phase 1, multicenter, open-label study evaluating the safety and efficacy of ruxolitinib, steroids and lenalidomide among MM patients who currently show progressive disease.

immunoglobulins
heparin
bone lesion
neutrophil count
aspirin
  • 36 views
  • 29 Apr, 2022
  • 7 locations
Subcutaneous Immunoglobulin in De-novo CIDP (SIDEC)

SIDEC - (Subcutaneous Immunoglobulin in De-novo CIDP) ia a study designed as a randomized, parallel study with an open-label extension phase. The aims are to compare the effect of SCIG and IVIG in 60 treatment-nave CIDP patients, and to detect the lowest effective dosage for maintenance treatment.

  • 12 views
  • 25 Jan, 2021
  • 4 locations
rATG Versus rATG Combined With Intravenous Immunoglobulin (IVIG) Induction Immunosuppression in HLA Incompatible Transplantation (INHIBIT)

This study aims to prove similar efficacy of PE/rATG (intervention) and PE/rATG/IVIG (centre standard of care) induction regimens to prevent biopsy proven antibody-mediated changes and TCMR as composite endpoint within 12 months after HLA incompatible kidney transplantation.

  • 0 views
  • 13 Apr, 2021
  • 1 location
Intravenous Immunoglobulin and Prednisolone for RPL After ART.

Recurrent pregnancy loss (RPL) affects around 5 % of women in reproductive age. The underlying cause of RPL is most often unknown, probably multifactorial, and no treatment with documented effect on chance of live birth exists. In unexplained cases of RPL, primarily the immune system is hypothesized to play a …

l-arginine
pregnancy tests
  • 0 views
  • 01 Aug, 2021
  • 1 location
Anti T-lymphocyte Immunoglobulin With Post Transplant Cyclophosphamide to Prevent GVHD Post Allogeneic Transplantation

Investigators hypothesize that combination of ATLG with PTCy in matched or mismatched unrelated hematopoietic stem cell transplantation will reduce acute and chronic GVHD incidence. Furthermore it will allow shortening of the length of post-transplantation immunosuppression with calcineurin inhibitor (CNI) administration (currently administrated in addition to ATG as GVHD prophylaxis in …

calcineurin inhibitor
cyclophosphamide
chronic graft versus host disease
busulfan
immunosuppression
  • 13 views
  • 16 May, 2022
  • 1 location
Personalized Treatment in Thyroid Disorders

The Collar Therapy Indicator (CoTI) (A device that is placed in collar around the neck resembling a turtle neck sweater collar with a wire and recording box) has been shown in a single small previously published experience to provide data regarding radioiodine exposure that correlates with conventional methods of measuring …

cancer
graves
radiation exposure
hyperthyroidism
hypothyroidism
  • 363 views
  • 01 Feb, 2022
  • 1 location
Infliximab and Intravenous Immunoglobulin Therapy in Treating Patients With Steroid-Refractory Pneumonitis

This phase II trial studies how well infliximab and intravenous immunoglobulin therapy work in treating patients with pneumonitis that does not respond to steroid treatment. Immunotherapy with monoclonal antibodies such as, infliximab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow …

cancer
antibiotics
monoclonal antibodies
hematologic malignancy
antibody therapy
  • 0 views
  • 18 Nov, 2021
  • 5 locations
Feasibility Study of a New Immunoglobulin E (IgE) Assay Method (LuLISA)

The main objective is to study the feasibility of a new specific IgE assay using a bioluminescence technique in a pediatric and adult allergic population. For this, we will collect blood, and urine during a blood test scheduled for the follow-up of the patient.

  • 0 views
  • 23 May, 2022
  • 2 locations