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Found 83 clinical trials
The Efficacy and Safety of ZR2 Versus R-CHOP-like Regimen for Elderly Patients With Newly Diagnosed Diffuse Large B Cell Lymphoma.

This is a prospective, single-center, open-label clinical study designed to evaluate the efficacy and safety of the Zanubrutinib, Lenalidomide and Rituximab (ZR2) versus rituximab combined with CHOP or CDOP (R-CHOP or R-CDOP) in elderly patients with diffuse large B cell lymphoma treated for the first time.

  • 28 Jun, 2022
  • 1 location
Eltrombopag Treatment in Patients With Prolonged BM Toxicity After CART

Treatment with chimeric antigen receptor-T cell (CAR-T) is successful in patients who have not responded to chemotherapy or bone marrow transplantation but it may provoke side effects and long-term complications. Early and specific side effects include cytokine release syndrome and neurological toxicity. In addition, there are also late side effects. …

multiple myeloma
cancer chemotherapy
neutrophil count
  • 01 May, 2022
  • 1 location
Venetoclax and Acalabrutinib in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma

This phase II trial studies how well venetoclax and acalabrutinib work in treating patients with mantle cell lymphoma that did not respond to previous treatment or has come back. Venetoclax may cause cancer cell death by blocking the mechanism that cancer cells use to stay alive. Acalabrutinib may stop the …

gilbert's syndrome
refractory mantle cell lymphoma
platelet count
  • 02 Mar, 2022
  • 1 location
Swedish Study of Immunotherapy for Milk Allergy in Children

This trial is a two-armed open randomized controlled trial in children aged 5-15 years with challenge proven Immunoglobulin E (IgE)-associated milk allergy.The purpose is to determine if oral immunotherapy with milk can induce tolerance to milk. The active intervention is intake of increasing amounts of fresh milk for six months …

allergy in children
milk allergy
milk proteins
allergic symptoms
  • 24 Jan, 2021
  • 1 location
Romiplostim Rituximab and Dexamethasone as Frontline Treatment for Immune Thrombocytopenia

The purpose of this study is to determine the response rate and response duration with the combination of low-dose rituximab, romiplostim and high-dose dexamethasone.

platelet count
  • 25 Jan, 2021
  • 1 location
Immunoadsorption Therapy in Managing NMDAR Antibodies Encephalitis

The purpose of the study is to assess the efficacy of immunoadsorption therapy (IA) on improving the neurological status of severe pediatric anti-NMDAR encephalitis patients.

  • 02 Dec, 2021
  • 1 location
The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis (ExTINGUISH)

Determine the difference in the modified Rankin score at 16 weeks in participants with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis treated with "first-line" immunomodulatory therapies provided as standard-of-care, and either inebilizumab (investigational agent) or placebo.

  • 30 Jun, 2022
  • 8 locations
The Effect of Donation Frequency on Donor Health in Blood Donors Donating Plasma by Plasmapheresis

This project is a randomized controlled non-inferiority study that aims to cover knowledge gaps about the composition and development of plasma proteins, inflammation markers and mental health in Norwegian, voluntary, and unpaid blood donors who donate plasma and blood. We will include 120 male blood donors who are randomized into …

Accepts healthy volunteers
  • 13 Mar, 2022
  • 1 location
Pilot Trial of Eltrombopag in Patients Undergoing Chemotherapy for Malignant Solid Tumors

Primary Objective: To assess safety of eltrombopag in pediatric patients undergoing intensive chemotherapy for malignant solid tumors. Secondary Objectives: To assess the efficacy of eltrombopag in increasing platelet count up to 2 weeks after completion of chemotherapy in pediatric patients undergoing intensive chemotherapy for malignant solid tumors. Hypothesis: The hypothesis …

  • 02 Aug, 2021
  • 1 location
Study of Pomalidomide Oral Dexamethasone and Ixazomib in Patients With Relapsed MM Who Have Received Lenalidomide

The purpose of this study is to evaluate the efficacy and safety of ixazomib, oral dexamethasone and in patients with relapsed multiple myeloma who have received lenalidomide.

granulocyte colony stimulating factor
colony stimulating factor
  • 28 Aug, 2021
  • 1 location