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Found 53 clinical trials
Phase 1/2 First-in-Human (FIH) Study of Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2) Inhibitor Monoclonal Antibody (mAb) JTX-8064, as Monotherapy and in Combination With a Programmed Cell Death Receptor-1 (PD-1) Inhibitor, in Adult Subjects With Advanced Refractory Solid Tumor Malignancies

JTX-8064-101 is a Phase 1/2, open label, dose escalation and dose expansion clinical study to determine the safety, tolerability, and recommended Phase 2 dose of JTX-8064 alone and in combination with a PD-1 inhibitor (PD-1i).

primary cancer
solid tumor
  • 10 views
  • 28 Oct, 2022
  • 43 locations
Feasibility Study of a New Immunoglobulin E (IgE) Assay Method (LuLISA)

The main objective is to study the feasibility of a new specific IgE assay using a bioluminescence technique in a pediatric and adult allergic population. For this, we will collect blood, and urine during a blood test scheduled for the follow-up of the patient.

  • 0 views
  • 23 May, 2022
  • 2 locations
Breastfeeding and Gut Health (PENSINE)

years and 4 years of age for implementing a biological collection. Gut health will be evaluated in children during the first four years of life based on fecal secretory immunoglobulin A (SIgA) and

  • 0 views
  • 04 Oct, 2022
  • 1 location
Epstein-Barr Virus Antibody and Epstein-Barr Virus DNA for Nasopharyngeal Carcinoma Screening

The investigators intend to compare Epstein-Barr virus antibody and Epstein-Barr virus DNA screening efficacy in first-degree relatives of nasopharyngeal carcinoma patients.

epstein-barr virus deoxyribonucleic acid
nasopharyngeal carcinoma
carcinoma
  • 0 views
  • 04 Oct, 2022
  • 1 location
KOrea Renal Biobank NEtwoRk System TOward NExt-generation Analysis (KORNERSTONE)

Glomerulonephritis (GN) generates an enormous individual and social economic burden. However, the therapeutic options are largely based on clinical and pathological parameters and the individual response to therapy or prognosis is uncertain. Recently, along with advances in molecular analysis and computational bioinformatics, genomic data from human renal biopsies could provide …

glomerulonephritis
glomerulopathy
kidney biopsy
kidney transplant
glomerular disease
  • 58 views
  • 05 Feb, 2022
  • 3 locations
Drug Reactions Sampling (COLLECTIONTOXIDERMIES)

), Lyell syndrome (toxic epidermal necrolysis (TEN)), generalized bullous fixed drug reactions, AGEP, DRESS, drug induced immunoglobulin A (IgA) bullous dermatosis, and erythema multiforme). In order to

  • 0 views
  • 12 May, 2022
  • 1 location
Trajectory of Microbiota Maturation in Healthy Bern Infants - a Network Approach (TMM)

Background: Intestinal microbiota composition is fundamental to human health and undergoes critical changes within the first two years of life. Factors probably influencing the microbiota are the maternal microbiota and the general environment in Switzerland. However, the development of the intestinal microbiota is incompletely understood. Gaining knowledge of the trajectory …

Accepts healthy volunteers
  • 0 views
  • 05 Jun, 2022
  • 1 location
Prognostic Value of Cerebrospinal Fluid Immunoglobulin Free Light Chains in Patients With Multiple Sclerosis

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system, usually presenting as clinically isolated syndrome (CIS). The course of MS following first symptoms is unpredictable, as approximately 30% of patients with MS have a benign course and don't develop significant disability while another 20-30% progress …

MRI
fatigue
optic neuritis
nervous
disease or disorder
  • 0 views
  • 19 Oct, 2021
  • 1 location
Immunoglobulin Deficiency a Treatable Cause of Fatigue in Patients With Multiple Sclerosis (MS)? - A Prospective Observational Fatigue Trial (FatIgG)

The investigators hypothesize that hypogammaglobulinemia (defined as IgG serum concentration <7.0g/L) is a treatable cause of fatigue in people with MS: The primary objective is to prove the link between hypogammaglobulinemia and fatigue in patients with multiple sclerosis. The secondary objective is to show that fatigue is mediated via frequent …

  • 0 views
  • 14 Oct, 2022
Optimization of Dosing of Immunoglobulin G in the Obese Population

The overall goal of this proposal is to investigate effects of obesity on pharmacokinetics of immunoglobulin G (IgG) and to develop strategies for optimization of dosing of IgG in obese patients. There is an ongoing debate regarding the most appropriate dosing of IgG formulations in obese patients. Obesity poses significant …

immune globulin
igiv
fats
  • 0 views
  • 22 Oct, 2022
  • 1 location