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Found 54 clinical trials
Visionary Study: Phase 3 Trial of Sibeprenlimab in Immunoglobulin A Nephropathy (IgAN)

This is a phase 3 study to evaluate effects on proteinuria and glomerular filtration rate of sibeprenlimab 400 mg subcutaneously (s.c.) Q 4 weeks in adults with IgAN who are receiving maximally tolerated standard-of-care therapy.

glomerular filtration rate
nephropathy
immunoglobulin a
proteinuria
kidney biopsy
  • 0 views
  • 22 Apr, 2022
  • 1 location
A Study of the Safety and Activity of Sparsentan for the Treatment of Incident Patients With Immunoglobulin A Nephropathy (SPARTAN)

To determine the nephroprotective potential of treatment with sparsentan in patients newly-diagnosed with immunoglobulin A nephropathy (IgAN) (ie, incident patients) who have not received prior

enzyme inhibitor
nephropathy
proteinuria
immunoglobulin a
angiotensin
  • 4 views
  • 03 Jun, 2022
  • 1 location
A Study to Evaluate the Effectiveness and Safety of IONIS-FB-LRx, an Antisense Inhibitor of Complement Factor B, in Adult Participants With Primary IgA Nephropathy

effect of IONIS-FB-LRx on plasma factor B (FB) levels and serum AH50, CH50 activity in participants with primary immunoglobulin A (IgA) nephropathy.

  • 16 views
  • 04 Oct, 2022
  • 6 locations
SodiUm Restriction by Behavioral Intervention (SURBI)

The aim of this study is to evaluate the effects and efficacy of dietary sodium restriction by mean of a new healthcare approach in patients with immunoglobulin A nephropathy. The test persons

chronic kidney disease
nephropathy
immunoglobulin a
proteinuria
  • 0 views
  • 14 May, 2022
  • 1 location
A Randomized Clinical Trial to Measure Efficacy of Music on Cardiac Surgery Patients

) and immunologic biomarkers Immunoglobulin A to a music intervention. Therefore, the purpose of this study is to measure both psychological/physical response and biomarkers pre and post a 30-minute

bypass surgery
  • 0 views
  • 04 Oct, 2022
  • 1 location
Relationship Between Oral Findings and Salivary Factors in Sars-Cov-2 Patients

appointment. Oral swap samples will be collected with sterile swap brushes (Six sample for each person) on the 1st, 7th and 30th days to evaluate the salivary immunoglobulins (Immunoglobulin A (IgA

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study

The purpose of this study is to determine if adding dietary fiber, such as inulin, to a diet that does not have enough fiber would raise the levels of potentially beneficial bacteria, such as Bifidobacterium, in the gut. There is evidence to suggest that these microbes can affect gut health …

Accepts healthy volunteers
  • 0 views
  • 14 Oct, 2022
  • 1 location
Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response

This is a 16-week, open-label study to identify factors that help predict clinical responses to DMARD therapies for RA (Rheumatoid Arthritis) patients. All patients will receive a starting dose of DMARD medication(s) which may be adjusted by the investigator as needed. If a subject becomes intolerant to a DMARD medication …

rheumatoid factor
folate
withdrawn
rituximab
golimumab
  • 14 views
  • 26 Feb, 2022
  • 1 location
The Influence of Body Composition on Immunoglobulin Disposition After Intravenous and Subcutaneous Administration

Current dosing practices for immunoglobulin G (IgG) may be inadequate in extreme body weight. The current study will evaluate the influence of body composition on intravenous and subcutaneous administration of immunoglobulin G in patients.

  • 0 views
  • 23 Oct, 2022
Study of JYB1904 (an Anti-immunoglobulin E Antibody) in Healthy Chinese Subjects

This phase Ia study is meant to evaluate the tolerability, safety, pharmacokinetics, preliminary pharmacodynamics, and immunogenicity of single-dose JYB1904, an anti-immunoglobulin E (IgE) antibody, in healthy Chinese subjects.

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location