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Found 1095 clinical trials
Very Early Intensive Treatment of HIV-Infected Infants to Achieve HIV Remission

The study will explore the effects of early intensive antiretroviral therapy (ART) on achieving HIV remission (HIV RNA below the limit of detection of the assay) among HIV-infected infants.

immune globulin
hiv antibody
nevirapine
antiretroviral agents
hiv dna
  • 94 views
  • 26 Jul, 2021
  • 50 locations
Evaluating the Pharmacokinetics Feasibility Acceptability and Safety of Oral Pre-Exposure Prophylaxis for HIV Prevention During Pregnancy and Postpartum

The purpose of this study is to evaluate the pharmacokinetics, feasibility, acceptability, and safety of a fixed-dose combination of emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) as oral daily pre-exposure prophylaxis (PrEP) to prevent HIV during pregnancy and postpartum in adolescents and young women and their infants.

HIV Vaccine
drug level
pre-exposure prophylaxis (prep)
hepatitis
tenofovir
  • 48 views
  • 24 Jan, 2021
  • 6 locations
HealthMindr App to Increase Pre-exposure Prophylaxis (PrEP) Uptake and Retention Among Men Who Have Sex With Men (MSM)

prevent human immunodeficiency virus (HIV). Participants in the intervention arm will receive access to the HealthMindr app, with information about PrEP and other HIV prevention methods in addition to

pre-exposure prophylaxis (prep)
hiv test
immunodeficiency
HIV Vaccine
  • 141 views
  • 15 Jun, 2021
  • 3 locations
Improving Health Outcomes in Young Cisgender Men and Transgender Women (mLab App)

The mLab App combines HIV prevention information with push notifications/reminders to complete HIV testing and an automated image processing feature to provide real-time feedback on home-based HIV test results. Theoretically-guided by the Health Information Technology Usability Evaluation Model (Health-ITUEM), the proposed project will refine and test a next-generation diagnostic intervention …

hiv test
AIDS
HIV Vaccine
  • 18 views
  • 31 Jul, 2021
  • 1 location
Characterization of Acute and Recent HIV-1 Infections in Zurich: a Long-term Observational Study

Aim of the study: To describe the epidemiology, longitudinally follow, test the effect of early antiretroviral treatment and investigate early events of virus-host interactions in patients with documented acute or recent HIV-1 infection in Zurich. Study design: This is an open label, non-randomized, observational, single center study at the University …

elvitegravir
darunavir
antiretroviral agents
tenofovir
protease
  • 9 views
  • 21 Jan, 2021
  • 1 location
Dolutegravir and Darunavir Evaluation in Adults Failing Therapy

DEFT is a randomised, open-label study in HIV-1 infected patients failing first-line antiretroviral therapy (ART). The study compares 2 regimens of second-line ART (dolutegravir and darunavir pharmaco-enhanced with ritonavir and dolutegravir and 2 prespecified NRTIs) with the WHO recommended regimen of 2NRTIs plus a ritonavir-boosted PI (Standard of Care (SOC)). …

antiretroviral
HIV Vaccine
darunavir
antiretroviral agents
ritonavir
  • 1172 views
  • 25 Mar, 2021
  • 32 locations
A Randomized Trial to Prevent HIV Among Gay Couples

The proposed study is a randomized controlled intervention to reduce sexual risk for HIV among HIV-negative concordant and HIV discordant gay couples. There are three arms of the study: 1) the in-person experimental condition, PRIDE, 2) the online adaptation of the experimental condition, ePRIDE, and 3) the time- and attention-matched …

HIV Vaccine
  • 106 views
  • 22 Jan, 2021
  • 1 location
Evaluating the Safety and Efficacy of Long-Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for Pre-Exposure Prophylaxis in HIV-Uninfected Women

This study will evaluate the safety and efficacy of the long-acting injectable agent cabotegravir (CAB LA) compared to daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) for pre-exposure prophylaxis (PrEP) in HIV-uninfected women.

HIV Vaccine
immune globulin
pre-exposure prophylaxis (prep)
hysterectomy
hepatitis
  • 767 views
  • 25 Jan, 2021
  • 22 locations
A Study Evaluating Implementation Strategies for Cabotegravir (CAB)+ Rilpivirine (RPV) Long-acting (LA) Injectables for Human Immunodeficiency Virus (HIV)-1 Treatment in European Countries

The overall objective of the CAB LA + RPV LA clinical development program is to develop a highly effective, well-tolerated, two-drug, LA injectable regimen which has the potential to offer improved treatment convenience, compliance and improved quality of life for people living with HIV compared to current standard of care. …

immunodeficiency
HIV Vaccine
antiretroviral
hiv-1 rna measurement
local anesthetic
  • 0 views
  • 08 Jul, 2021
  • 15 locations
Viral Load Triggered ART Care in Lesotho

This cluster randomized clinical trial at 18 nurse-led rural health centers in Lesotho will test an automated differentiated service delivery model using viral load results, other clinical characteristics and participants' preference to automatically triage participants into groups requiring different levels of attention and care.

tuberculosis
antiretroviral therapy
antiretroviral agents
  • 0 views
  • 07 Jun, 2021
  • 14 locations