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Found 181 clinical trials
Anti-PD-1 Antibody Combined With Peg-Asparaginase and Chidamide for the Early Stage of NK/T Cell Lymphoma

This prospective pilot study to evaluate the efficacy and safety of the anti-PD-1 antibody combine with Peg-asparaginase and Chidamide regimen for stage IE and IIE ENKTL.

cancer
measurable disease
serum bilirubin
peg-asparaginase
neutrophil count
  • 0 views
  • 24 Jan, 2021
  • 1 location
Toripalimab Based Induction Chemotherapy Followed by De-escalation Protocols in HPV-related OPSCC

Human papillomavirus (HPV)-related oropharyngeal carcinoma are exquisitely radiosensitive. Several studies attempted to reduce the toxicities of treatments through reduced-dose radiation and showed promising results, but all data were collected from non-Chinese areas. Like nasopharyngeal carcinoma (NPC), oropharyngeal carcinoma may have different biological behavior and relationship with HPV infection. So the …

  • 0 views
  • 11 May, 2021
  • 1 location
LIquid Biopsy to prEdict Responses To First-line immunotherapY in Metastatic Non-small Cell LUNG Cancer. LIBERTY LUNG

Patient with histologically proven NSCLC in a metastatic stage, treatment nave and eligible for first-line treatment with immune checkpoint inhibitor. Combination with chemotherapy is possible

  • 0 views
  • 20 Jul, 2021
  • 3 locations
Study of Core Needle Biopsy and Cryoablation of an Enlarging Tumor in Patients With Metastatic Lung Cancer and Metastatic Melanoma Receiving Post-progression Immune Checkpoint Inhibitor Therapy

This research study is studying cryoablation (a treatment to kill cancer cells with extreme cold) combined with continued treatment with current immune checkpoint inhibitor as a possible

cancer
measurable disease
lung cancer
x-rays
ct scan
  • 8 views
  • 04 Mar, 2022
  • 1 location
Neoadjuvant/Adjuvant Pembrolizumab Plus Chemotherapy (NeoP)

A phase II, single-arm, open-label study evaluating feasibility, safety and efficacy of combined chemotherapy and pembrolizumab as neoadjuvant/adjuvant therapy in stage IIa-IIIB NSCLC adult patients followed by adjuvant PD-(L)1 inhibitor treatment for up to 1 year

EGFR
kidney function test
metastasis
platelet count
proto-oncogene tyrosine-protein kinase ros
  • 0 views
  • 02 Jun, 2022
  • 1 location
Toripalimab Plus FLOT in Locally Advanced Gastric Cancer

Neoadjuvant therapy for locally advanced gastric cancer is still in the exploratory stage. With the emergence of immune checkpoint inhibitors, neoadjuvant chemoimmunotherapy is also in the exploratory stage in locally advanced gastric cancer. At present, chemotherapy combined with immunotherapy is usually a simple combination of chemotherapeutic drugs and immune drugs, …

cancer
metastasis
hepatitis
renal function
chemotherapy regimen
  • 0 views
  • 10 Mar, 2022
  • 1 location
Tofacitinib for the Treatment of Refractory Immune-related Colitis From Checkpoint Inhibitor Therapy- TRICK Study

This is a single-arm pilot study evaluating the efficacy and safety of tofacitinib in cancer patients with immune-related colitis from immune checkpoint inhibitor (ICI) therapy.

  • 0 views
  • 30 May, 2022
  • 1 location
A Trial of ChAdOx1 and MVA Vaccines Against MAGE-A3 and NY-ESO-1

This clinical trial is looking at two new vaccines called ChAdOx1-MAGEA3-NYESO and MVA-MAGEA3 given with patients' standard of care treatment (chemotherapy and an immune checkpoint inhibitor

measurable disease
platelet count
anticoagulants
cancer chemotherapy
pembrolizumab
  • 0 views
  • 26 Dec, 2021
  • 8 locations
A Study of KN046 in Patients With Thymic Carcinoma Who Failed Immune Checkpoint Inhibitors

This study will assess the safety and efficacy of the study drug KN046 in patients with advanced thymic carcinoma who progressed after prior treatment with immune checkpoint inhibitor therapy

progressive disease
measurable disease
metastasis
aptt
renal function
  • 0 views
  • 01 Dec, 2021
  • 1 location
Safety and Efficacy Study of IMSA101 in Refractory Malignancies

Open-label, dose escalation (Phase I) and dose expansion (Phase IIA) study of patients receiving intra-tumoral IMSA101 alone or in combination with an immune checkpoint inhibitor (ICI) (Phase I

cancer
metastasis
measurable disease
aptt
breast cancer
  • 12 views
  • 05 May, 2022
  • 6 locations