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Found 4 clinical trials
Phase I Study of AZD5363 + Olaparib + Durvalumab in Patients With Advanced or Metastatic Solid Tumor Malignancies

microenvironment in regulation of intratumoral immune regulators (i.e. T-regulatory cells) in improving response to Durvalumab To understand the role of AZD5363 as an immunomodulator To evaluate

  • 0 views
  • 22 Jan, 2021
  • 1 location
Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression

The standard Johns Hopkins' regimen will be used in study subjects, with the use of donor peripheral blood stem cells, rather than marrow. Clinical outcomes will be defined while focusing efforts on immune reconstitution focusing on immune checkpoint regulators after a related haploidentical stem cell transplant.

lymphoid leukemia
cancer
myeloproliferative disorder
multiple myeloma
acute leukemia
  • 168 views
  • 09 May, 2021
  • 1 location
Immune Regulation in Ulcerative Colitis or Crohn s Disease

This study will investigate in patients with Crohn s disease and ulcerative colitis how the body s immune system controls inflammation in the gastrointestinal tract (stomach and intestines)-specifically, how lymphocytes (a type of white blood cell) function in inflammatory responses. This protocol does not involve any experimental treatments. Patients between …

platelet count
fatigue
enemas
hematochezia
enteropathy
  • 64 views
  • 17 Mar, 2021
  • 1 location
Immune Regulation in Patients With Common Variable Immunodeficiency and Related Syndromes

This study will explore the cause of immunodeficiency in common variable immunodeficiency (CVI) and other related immunodeficiency syndromes-IgA deficiency, hyper IgM syndrome, thymoma and agammaglobulinemia, hypogammaglobulinemia associated with Epstein-Barr infection, and others to better focus on how to correct the underlying defect. Patients with CVI and their family members may …

hypogammaglobulinemia
x-rays
immune globulin
genetic tests
blood test
  • 530 views
  • 09 May, 2021
  • 1 location