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Found 13 clinical trials
Phase I, Dual Arm, Open-Label, Trial of Intralesional 5-Fluorouracil (5FU) and Intralesional 5FU Combined With Topical Imiquimod in Patients With Squamous Cell Carcinoma (SCC) of the Lower Extremities

and without a topical application of 5% imiquimod to kill topically accessible SCC cells. The goal of the study is to evaluate the safety profile and tolerability of intralesional-5FU with and without

antineoplastic
imiquimod
Accepts healthy volunteers
fluorouracil
  • 287 views
  • 24 Oct, 2022
  • 1 location
Trichloroacetic Acid as a Topical Treatment for Actinic Cheilitis

, imiquimod, ingenol mebutate and diclofenac. More recently, photodynamic therapy has been brought forward as a potential treatment modality. From a surgical perspective, a vermilionectomy is typically the

  • 0 views
  • 22 Aug, 2021
  • 1 location
Intradermal Influenza Vaccine With Topical Imiquimod in Elderly and Chronic Illness Patients

To compare the safety and clinical efficacy (death, overall hospitalization, hospitalization for influenza or pneumonia) of ID QIV delivered via an intradermal device with imiquimod cream

quadrivalent inactivated influenza vaccine
trivalent influenza vaccine
fluzone
  • 0 views
  • 16 Feb, 2022
  • 1 location
Topical Aldara (Imiquimod) for Oral Cancer

> To assess the preliminary efficacy of topical imiquimod in neoadjuvant setting in patients with early-stage oral squamous cell carcinoma as determined by best response rate (CR and PR). To assess

squamous cell carcinoma
carcinoma
oral cancer
tumor cells
  • 0 views
  • 07 Oct, 2022
  • 1 location
Immunotherapy for Recurrent Ependymomas in Children Using Tumor Antigen Peptides With Imiquimod

The purpose of this study is to see if vaccination with HLA-A2 restricted peptides, combined with the immunoadjuvant imiquimod is safe and can induce immune responses in children with recurrent

imiquimod
metastasis
ependymoma
neutrophil count
corticosteroids
  • 10 views
  • 22 Jan, 2022
  • 1 location
Vaccine Therapy With or Without Imiquimod in Treating Patients With Grade 3 Cervical Intraepithelial Neoplasia

RATIONALE: Vaccines made from DNA or a gene-modified virus may help the body build an effective immune response to kill tumor cells. Biological therapies, such as imiquimod, may stimulate the

human papilloma virus vaccine
measurable disease
cervical intraepithelial neoplasia
vaccine therapy
PCR test
  • 55 views
  • 04 Oct, 2022
  • 1 location
Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions

This randomized phase III trial studies imiquimod or fluorouracil to see how well they work compared to observation in treating patients with high-grade anal squamous skin lesions who are human

imiquimod
immune globulin
hsil
enzyme-linked immunosorbent assay
immunodeficiency
  • 32 views
  • 04 Oct, 2022
  • 12 locations
A Study to Evaluate Neoadjuvant Sonidegib Followed by Surgery or Imiquimod in the Management of Basal Cell Carcinoma (SONIB)

In this study, patients with BCC will be given neoadjuvant treatment with a drug called sonidegib. Sonidegib is a daily tablet usually given for BCC that cannot be removed by surgery or that has spread through the body. The study aims to see if sonidegib given for 12 weeks will …

imiquimod
sonidegib
carcinoma
adjuvant therapy
scarring
  • 5 views
  • 02 Jul, 2022
  • 1 location
A Phase 1b, Multicenter Study to Determine the Dose, Safety, Efficacy and Pharmacokinetics of TRK-950 When Used in Combinations With Selected Anti-Cancer Treatment Regimens in Patients With Selected Advanced Solid Tumors

/ Paclitaxel, PD1 inhibitors (Nivolumab or Pembrolizumab), and Imiquimod Cream, Bevacizumab, Gemcitabine / Carboplatin / Bevacizumab, Topotecan, and Pegylated liposomal doxorubicin (PLD) for selected advanced

taxane
ovarian cancer
doxorubicin
leucovorin
paclitaxel
  • 20 views
  • 25 Oct, 2022
  • 14 locations
Immunologic Profile of Chronically Photodamaged Skin

immune system by giving an injection of Candida Albicans (CANDIN®) and histamine phosphate (HISTATROL®), topical applications of imiquimod 5% cream (ALDARA®) and performing a tape stripping procedure

Accepts healthy volunteers
  • 24 views
  • 02 Jun, 2022
  • 1 location