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Found 83 clinical trials
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia

ALLTogether collects the experience of previously successful treatment of infants, children and young adults, with ALL from a number of well-renowned study groups into a new master protocol, which is both a comprehensive system for stratification and treatment of ALL in this age-group as well as the basis for several …

imatinib
doxorubicin
dexamethasone
vincristine
inotuzumab
  • 71 views
  • 15 Jun, 2022
  • 59 locations
Imatinib for Multiple Sclerosis (MS) Relapses

To investigate if treatment with Imatinib results in a better outcome than standard care in form of Methylprednisolone(MP) after MS-associated relapses.

MRI
oligoclonal bands
clinically isolated syndrome
methylprednisolone
  • 14 views
  • 14 Feb, 2022
  • 12 locations
Imatinib for Pain in Sickle Cell Anemia (IMPACT)

In this protocol, the investigators propose to evaluate the biochemical effects of imatinib on sickle red blood cells (RBCs). Patients will be administered imatinib mesylate orally following the

acute chest syndrome
opiates
Accepts healthy volunteers
electrophoresis
chest syndrome
  • 0 views
  • 26 Jan, 2022
  • 2 locations
Flumatinib in CML-CP Patients With Ph+ Post Imatinib Failure

The purpose of this study is to explore the efficacy and safety of flumatinib in chronic phase of chronic myeloid leukemia (CML-CP) patients With Ph+ post imatinib failure.

  • 0 views
  • 02 Feb, 2021
  • 1 location
PDR001 Plus Imatinib for Metastatic or Unresectable GIST

Assuming that PDR001, an anti-PD-1 antibody, with imatinib might be effective in advanced GIST after failure of standard TKI therapies including imatinib, sunitinib, and regorafenib. In this

imatinib
measurable disease
metastasis
sunitinib
regorafenib
  • 3 views
  • 07 Feb, 2022
  • 1 location
Imatinib Mesylate in Combination With Pembrolizumab in Patients With Melanoma

This is an open-labelled single arm trial of pembrolizumab and imatinib mesylate in subjects with unresectable or metastatic KIT-mutant melanoma that are refractory to standard therapy. The

measurable disease
pembrolizumab
metastatic melanoma
KIT
immunologic adjuvant
  • 0 views
  • 19 Apr, 2022
  • 1 location
Trial of Imatinib for Hospitalized Adults With COVID-19

This study is a randomized Double-Blind Placebo-Controlled Trial on the Safety and Efficacy of Imatinib for Hospitalized Adults with COVID-19

covid-19
SARS
oropharyngeal
  • 74 views
  • 22 Aug, 2021
  • 1 location
Three Versus Five Years of Adjuvant Imatinib as Treatment of Patients With Operable GIST

In this study, patients who have been diagnosed with gastrointestinal stromal tumor (GIST) and have been treated with adjuvant imatinib for 3 years after surgery will be randomly allocated in a

imatinib
gastrointestinal stromal tumor
ct scan
gleevec
stromal tumor
  • 7 views
  • 23 Mar, 2022
  • 1 location
Prospective Multicenter Clinical Study of Neoadjuvant Imatinib Mesylate for Gastrointestinal Stromal Tumors

improved. A few retrospective analyses and a small sample of prospective studies have found that neoadjuvant therapy with imatinib mesylate can improve R0 resection rates. Whether neoadjuvant therapy

  • 0 views
  • 17 Oct, 2021
  • 1 location
Flumatinib Versus Imatinib Combined With Chemotherapy for de Novo Ph+ ALL

potent binding affinity for BCR-ABL1 tyrosine kinase than imatinib, demonstrated higher rates of responses, faster and deeper responses in FESTnd trial, which suggested that flumatinib might show

  • 0 views
  • 17 Oct, 2021
  • 1 location