Found 62 clinical trials
International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL) Testing Imatinib in Combination With Two Different Cytotoxic Chemotherapy Backbones
This randomized phase III trial studies how well imatinib mesylate works in combination with two different chemotherapy regimens in treating patients with newly diagnosed Philadelphia chromosome
- 310 views
- 12 Oct, 2022
- 168 locations
A Phase 3 Study for the Efficacy and Safety of Radotinib in CP-CML Patients With Failure or Intolerance to Previous TKIs
therapy including Imatinib will be recruited. In this phase 3 study, 173 subjects are expected to be enrolled in a single arm with the administration of Radotinib 400mg twice daily, which includes 10% of
- 18 views
- 25 Mar, 2022
- 15 locations
A Phase III, Multi-center, Open-label, Randomized Study of Oral Asciminib Versus Investigator Selected TKI in Patients With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in Chronic Phase
Investigator selected TKI will be one of the following treatment options for first-line treatment of CML-CP - imatinib 400 mg QD or nilotinib 300 mg BID or dasatinib 100 mg QD or bosutinib 400 mg QD.
- 2 views
- 23 Oct, 2022
- 137 locations
Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial (CATCO)
This study is an adaptive, randomized, open-label, controlled clinical trial, in collaboration with countries around the world through the World Health Organization.
- 1533 views
- 04 Oct, 2022
- 45 locations
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
ALLTogether collects the experience of previously successful treatment of infants, children and young adults, with ALL from a number of well-renowned study groups into a new master protocol, which is both a comprehensive system for stratification and treatment of ALL in this age-group as well as the basis for several …
- 74 views
- 04 Oct, 2022
- 61 locations
Imatinib for Multiple Sclerosis (MS) Relapses
To investigate if treatment with Imatinib results in a better outcome than standard care in form of Methylprednisolone(MP) after MS-associated relapses.
- 14 views
- 14 Feb, 2022
- 12 locations
Imatinib for Pain in Sickle Cell Anemia (IMPACT)
In this protocol, the investigators propose to evaluate the biochemical effects of imatinib on sickle red blood cells (RBCs). Patients will be administered imatinib mesylate orally following the
- 0 views
- 04 Oct, 2022
- 2 locations
Trial of Imatinib for Hospitalized Adults With COVID-19
This study is a randomized Double-Blind Placebo-Controlled Trial on the Safety and Efficacy of Imatinib for Hospitalized Adults with COVID-19
- 74 views
- 04 Oct, 2022
- 1 location
Imatinib Mesylate in Combination With Pembrolizumab in Patients With Melanoma
This is an open-labelled single arm trial of pembrolizumab and imatinib mesylate in subjects with unresectable or metastatic KIT-mutant melanoma that are refractory to standard therapy. The
- 0 views
- 19 Apr, 2022
- 1 location
Flumatinib in CML-CP Patients With Ph+ Post Imatinib Failure
The purpose of this study is to explore the efficacy and safety of flumatinib in chronic phase of chronic myeloid leukemia (CML-CP) patients With Ph+ post imatinib failure.
- 1 views
- 02 Feb, 2021
- 1 location