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Found 245 clinical trials
Characterization of Regulatory T Lymphocytes in the Synovial Fluid of Patients Affected by Rheumatoid Arthritis. (CATERLIS)

order to better characterize the Treg cell subsets within the synovial fluid. Moreover, the local inflammatory cytokines (TNF, IL-6 and IL-1) may affect both the phenotype and the suppressive function

tumor necrosis factor alpha
tumor necrosis factor
edema
  • 7 views
  • 23 Mar, 2022
  • 1 location
Neural Response to Inflammatory Challenge in Major Depressive Disorder

neurophysiological response to LPS. The main outcome variables are symptoms of anhedonia measured with the Snaith-Hamilton Pleasure Scale (SHAPS), cytokines (Il-6, IL-8, IL-10, and TNF), and BOLD signal change in

Accepts healthy volunteers
  • 0 views
  • 09 Jul, 2022
  • 1 location
Bispecific PSMAxCD3 Antibody CC-1 in Patients With Squamous Cell Carcinoma of the Lung

activation with expected fewer side effects. Together with preemptive IL-6 receptor (IL-6R) blockade using tocilizumab, this allows for application of effective bsAb doses with expected high anticancer

  • 0 views
  • 25 Mar, 2022
A Safety Run-In and Phase II Study Evaluating the Efficacy, Safety, and Impact on the Tumor Microenvironment of the Combination of Tocilizumab, Atezolizumab, and Fractionated Stereotactic Radiotherapy in Recurrent Glioblastoma

back after initial treatment (recurrent). Tocilizumab is a monoclonal antibody that binds to receptors for a protein called interleukin-6 (IL-6), which is made by white blood cells and other cells in

  • 0 views
  • 24 Oct, 2022
  • 52 locations
Dexamethasone and Robotic-assisted Hysterectomy

-reactive protein as primary outcome and, further, other stress markers like white blood cells, Il-6, cortisol, and creatinine kinase. The postoperative recovery will be registered in validated charts and

  • 0 views
  • 04 Oct, 2022
  • 1 location
CARDIA-Salt Sensitivity of Blood Pressure (SSBP)

constructs, how Na+ itself influences BP remains incompletely understood. Our preliminary work suggests that excess Na+ induces a pro-inflammatory state that sustains higher BP. Interleukin-6 (IL-6) drives

24-hour ambulatory blood pressure monitoring
cardiovascular morbidity
Accepts healthy volunteers
diet, sodium-restricted
  • 136 views
  • 13 May, 2022
  • 2 locations
DASH INtervention to INvestigate the Gut (DINING)

systemic inflammation (e.g, calprotectin, IL-6) among participants receiving the DASH diet compared to the standard American diet. The investigator's findings will provide preliminary evidence for the DASH

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
Evaluation of Pain Sensitization in Rheumatoid Arthritis: Analysis on a Cohort of Tofacitinib Treated Patients (TOPRA)

implicated in the pathophysiology of RA, such as IL-6, IL-12, IL-23 and IFNs. Two Jak-inhibitors have been put on the market: Tofacitinib and Baricitinib. In randomized clinical trials, Tofacitinib have

baricitinib
depression
tofacitinib
prednisone
DMARD
  • 1 views
  • 11 Feb, 2022
  • 1 location
Safety and Efficacy of HA380 Hemoadsorption in Patients With Septic Shock

-molecular weight toxins on their surface. The cytokines absorved using this cartridge are IL-1, IL-6, IL-8, IL-10 in addition to TNF-8. Therefore, this study aims to examine the potential effects of

hemodiafiltration
renal replacement therapy
  • 0 views
  • 20 Aug, 2021
  • 1 location
Efficacy and Safety of Low Energy Shock Wave Plus BotulinumToxin A in Treating Patients With Interstitial Cystitis

prostatitis and chronic pelvic pain syndrome. LESW reduced pain behavior and down-regulated the NGF expression, suppressed bladder overactivity by decreasing inflammation, IL-6 and COX2 expression and NGF

urinary tract infection
botulinum toxin
bladder dysfunction
bladder outlet obstruction
pelvic pain
  • 0 views
  • 06 Apr, 2022
  • 1 location