Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 309 clinical trials
Efficacy and Safety of Selective JAK 1 Inhibitor Filgotinib in Active Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate

progression of joint destruction due to inhibition of the JAK-STAT pathway. IL-6 inhibitors such as tocilizumab also inhibit the JAK-STAT pathways due to inhibition of IL-6 signaling. We will evaluate whether

tocilizumab
methotrexate
antirheumatics
  • 0 views
  • 10 Nov, 2021
  • 1 location
Dose Escalation Study Assessing the Safety and Immune Response of PPV-06 Vaccine

PPV-06 immunotherapy targets interleukin-6 (IL-6), a key molecule of the immune system whose overproduction is implicated in many inflammatory and autoimmune diseases such as rheumatoid

body mass index
  • 1 views
  • 09 May, 2022
Bazedoxifene as a Concomitant Treatment of Patients With Metastatic Pancreatic Adenocarcinoma (BAZE)

Bazedoxifene, a selective estrogen receptor modulator is thought to have effective anti-tumoral properties for pancreatic cancer via IL-6 pathway (GP130/STAT3) inhibition. The objective

metastatic pancreatic adenocarcinoma
cancer chemotherapy
metastasis
adenocarcinoma
pancreatic adenocarcinoma
  • 0 views
  • 15 Mar, 2022
Effect of Vitamin D Supplement on Disease Activity in SLE

To study the effect of vitamin D supplementation on disease activity of SLE ( SLEDAI-2K ) and IL-6 level

nsaids
vitamin d
azathioprine
Accepts healthy volunteers
methotrexate
  • 0 views
  • 17 Mar, 2022
  • 1 location
Role of Cytosorb in Left Ventricular Assist Device Implantation

response prior to, during and early after CF-LVAD insertion. Among the cytokines IL-6 appears to play a major role. There is increasing demonstration of the efficacy of a cytokine haemoadsorption (HA

heart transplantation
heart failure
  • 0 views
  • 26 Jan, 2021
  • 1 location
An Open-Label Multi-Center Phase II Study of Neoadjuvant Atezolizumab-Based Combination Therapy in Men With Localized Prostate Cancer Prior to Radical Prostatectomy

growth of prostate cancer cells. IL-6 is expressed by prostate cancer and within the tumor microenvironment and shown to enhance prostate cancer and disease progression. Treatment with an anti-IL-6

neutrophil count
cancer
testosterone
androgens
testosterone level
  • 9 views
  • 27 Oct, 2022
  • 1 location
Extracorporeal Cytokine Adsorption as Additive Treatment of CAR-T Associated Cytokine Release Syndrome (CRS)

hrs). Primary endpoint is the change in plasma IL-6 between 0 and 24 hrs.

  • 0 views
  • 10 Apr, 2021
  • 2 locations
A Prospective Study of Tocilizumab for the Prevention of Graft Failure and Graft-versus-Host Disease in Haplo-Cord Transplantation

tocilizumab, an IL-6 receptor monoclonal antibody, to improve immune reconstitution and reduce relapse while preserving low rates of graft failure and graft versus host disease (GVHD).

chronic myeloid leukemia
myeloid leukemia
fludarabine
myeloproliferative disorder
antithymocyte globulin
  • 3 views
  • 18 Oct, 2022
  • 1 location
The Impact of Metformin on the Outcome of Gouty Arthritis in a Cohort of Egyptian Gouty Patients. (Mets in gout)

inflammation, inflammatory cytokines (IL-1β and IL-6), and life quality. Methods A prospective randomized, single-blinded parallel randomized control study included 100

arthritis
  • 0 views
  • 09 Jul, 2022
  • 1 location
Mitigating the Pro-inflammatory Phenotype of Obesity (MAPLE)

concentrations and endothelial cell expression of inflammatory markers (e.g., TNF-α, IL-6). Our study is a prospective study using a randomized, double-blinded design to test 4 weeks of SNA blockade

fasting
hypertension
insulin
insulin resistance
hemoglobin a1c
  • 0 views
  • 15 Jul, 2022
  • 1 location