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Found 307 clinical trials
Effect of SARS-CoV-2 Disease on Immune Responses, Disease Severity and Treatment Outcomes in Pulmonary Tuberculosis (COVID-19-TB)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the Coronavirus disease (COVID-19). Tuberculosis (TB) is the foremost cause of infectious deaths globally. In 2025, an additional 1.4 million TB deaths could occur as direct consequence of the COVID-19 pandemic. It is postulated that individuals with latent …

polymicrobial infection
  • 0 views
  • 04 Oct, 2022
  • 1 location
Microbiome and Immune Profiling in Infant With Cow's Milk Allergy

Non-IgE-mediated cow's milk allergy (CMPA) is associated to gastrointestinal symptoms, and its cause remains poorly understood, limiting the identification of specific markers to help with the diagnosis. Using a non-invasive method, the aim of this study is to identify new protein markers as well as to profile the bacteria (germs) …

Accepts healthy volunteers
  • 0 views
  • 19 Jun, 2022
  • 1 location
Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly (SmartAge)

Cognitive disorders increase with age and in the presence of metabolic diseases such as Type 2 Diabetes Mellitus (T2DM). In addition, digestive disorders, changes in dietary pattern and decreased activity negatively influence the microbiome. The hypothesis is that pharmacological intervention with metformin will modify the composition of the gut microbiota …

continuous glucose monitoring
metformin
type 2 diabetes mellitus
  • 0 views
  • 04 Oct, 2022
  • 1 location
Inter-relationships Among Glucose, Brain, Gut Microbiota and MicroRNAs (IRONmiRNA). (IRONmiRNA)

The brain is a recognized target of iron deposition. This process is enhanced by the presence of obesity and hyperglycemia and impacts cognitive functions. There is evidence suggesting that the gut microbiota composition modulates this process. It has been proposed that microRNAs are mediators in the dialogue between the composition …

Accepts healthy volunteers
bariatric surgery
  • 0 views
  • 16 May, 2022
  • 1 location
ACE2 Gender Differences in Stroke With COVID-19

The new coronavirus SARS-CoV-2, causes the COVID-19 infection, which showed a form of neurovirulence involving the Central and peripheral Nervous Systems [Baig et al, 2020]. In a mouse model for human ACE2 expression, the virus entered the brain mainly through the olfactory bulb pathway [Netland et al, 2008], with an …

pneumonia
stroke
  • 0 views
  • 24 Nov, 2021
  • 1 location
Profiling Recovery of Those Discharged Into the Community With COVID-19

Currently, there are few studies that have been established that consist of a variety of established and coherent approaches that sought to profile the determinants of recovery, nor used interrogative procedures to understand lasting physical impairment. In this context, measurements obtained from an assessment of cardio-respiratory responses to physiological stress …

acute respiratory infections
  • 0 views
  • 02 Jun, 2022
  • 1 location
Study of Neurodegenerative Diseases Induced Stem Cells in Patients and Healthy Family Controls. (NeuronsiPS)

Neurological and neurodegenerative diseases have a major impact in families and in the national health service due to the lack in many cases of effective and long-lasting therapies. The lack of these therapeutic strategies is due in large part to the difficulty of modeling these pathologies in vitro. In fact, …

parkinson's disease
  • 0 views
  • 10 May, 2022
  • 1 location