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Found 307 clinical trials
A Pivotal Phase 3 Trial to Evaluate the Safety and Efficacy of Clazakizumab for the Treatment of Chronic Active Antibody-mediated Rejection in Kidney Transplant Recipients (IMAGINE)

This trial investigates the efficacy and safety of clazakizumab [an anti-interleukin (IL)-6 monoclonal antibody (mAb)] for the treatment of CABMR in recipients of a kidney transplant.

  • 142 views
  • 20 Sep, 2022
  • 51 locations
SC IL-1Ra in SAH - Phase III Trial (SCIL) (SCIL)

the study treatment. Blood samples for plasma IL-6 will be obtained prior to randomisation and at day 3-5 post randomisation for IL-6 & IL-1 measurement. Safety will be measured at 30 days post

withdrawn
  • 59 views
  • 04 Jun, 2022
  • 12 locations
Maternal- Fetal Infection (InSPIRe)

The purpose of the protocol is to validate a novel point of care multiplex system to detect and characterize microorganisms responsible for neonatal sepsis, as well as biomarkers of infection, from a simple vaginal sample, in order to improve the prevention of perinatal bacterial infections.

  • 2 views
  • 14 Feb, 2022
  • 3 locations
Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) Antagonists

Background Chronic granulomatous disease (CGD) affects the immune system. People with CGD are more likely to get infections. Drugs can help control infections, but these treatments can cause side effects including kidney failure and deafness. Stem cell transplants can cure CGD, but these don t always work. Objective To find …

  • 0 views
  • 25 Jul, 2022
  • 1 location
Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During Interleukin-6 vs. Tumor Necrosis Factor Antibody Therapy (RABEX)

The present study will investigative the physiological effects of the cytokines interleukin-6 (IL-6) and tumor necrosis factor (TNF) on the adaptive changes to exercise in patients with

tumor necrosis factor
Accepts healthy volunteers
tumour necrosis
  • 0 views
  • 10 Mar, 2022
  • 1 location
Meal Delivery and Exercise

between novel serum biomarkers (70 kilodalton heat shock proteins (HSP70),Macrophage Inflammatory Proteins(MIP1b), soluble IL-6 receptor alpha-chain (sIL-6R)) and established but non-specific frailty

  • 0 views
  • 24 Dec, 2021
  • 1 location
Acute Response to Exercise in Patients With Rheumatoid Arthritis

interleukin 6 (IL-6) and tumor necrosis factors (TNF). Physical exercise is considered a first-line non-pharmacological treatment in RA, improving inflammatory and metabolic profile, functional capacity

tumor necrosis factor
tocilizumab
edema
tumour necrosis
  • 0 views
  • 04 Sep, 2021
  • 1 location
Combined Aerobic and Resistance Exercise Training in Metastatic Renal Cell Carcinoma

the exercise intervention in Interleukin 6 (IL-6), C-reactive Protein (CRP), Leptin, Transforming growth factor beta (TGF-beta), and Interferon (INF) gamma.

  • 0 views
  • 18 Apr, 2022
  • 1 location
Plasma Biomarker for Aflibercept in Advanced Colorectal Cancer

. plasma biomarker study (HGF, VEGF-A, VEGF-D, IFN-, Angiopoietin-2, sICAM-1, sVCAM-1, TIMP-1, PIGF (HS), IL-6 (HS), IL-8 (HS), sNeuropilin-1, Thrombospondin-2 , Osteopontin , sVEGFR1, sVEGFR2, sVEGFR3

  • 0 views
  • 29 Mar, 2021
  • 1 location
Low Level Tragus Stimulation in Acute Decompensated Heart Failure (TREAT-HF)

of cytokines such as C-reactive protein (CRP), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10) and Tumor Necrosis Factor alpha (TNFα) in patients with heart failure (HF). Increased

cytokines
vagal stimulation
acute heart failure
  • 0 views
  • 23 Feb, 2022
  • 1 location