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Found 153 clinical trials
SC IL-1Ra in SAH - Phase III Trial (SCIL)

the study treatment. Blood samples for plasma IL-6 will be obtained prior to randomisation and at day 3-5 post randomisation for IL-6 & IL-1 measurement. Safety will be measured at 30 days post

withdrawn
  • 4 views
  • 25 Jan, 2021
  • 11 locations
Interleukin-1 Blockade for Treatment of Cardiac Sarcoidosis

treatments currently used (eg: corticosteroids, methotrexate and TNF-alfa inhibitors). Interleukin-1 (IL-1) is the prototypical pro-inflammatory cytokine, also referred to as master regulator of the

  • 2 views
  • 26 Jan, 2021
  • 2 locations
The AMPK Modulator Metformin as a Novel Adjunct to Conventional Therapy in Patients With Knee Osteoarthritis

through the AMPKa2/ SIRT1 pathway. Metformin suppresses IL-1-induced oxidative and osteoarthritis-like inflammatory changes by enhancing the SIRT3/PINK1/Parkin signaling pathway, thereby indicating

  • 0 views
  • 19 Mar, 2021
  • 1 location
A Phase 1B Study of Canakinumab Spartalizumab Nab-paclitaxel and Gemcitabine in Metastatic PC Patients

This study combines canakinumab (ACZ885), a high-affinity human anti-interleukin-1 (IL-1) monoclonal antibody (mAb), and spartalizumab (PDR001), a mAb directed against human Programmed Death-1

  • 0 views
  • 05 Feb, 2021
  • 2 locations
Adrenocorticotropic Hormone (ACTH) for Post-op Inflammation in Proliferative Vitreoretinopathy (PVR)

This is a pilot study to measure levels of albumin and inflammatory cytokines [including Transforming Growth Factor-Beta (TGF-) and Interleukin-1 Beta (IL-1)] in the aqueous humor of post

  • 0 views
  • 03 Apr, 2021
  • 1 location
Honey Products for Cancer Patients With Oral Mucositis: a Randomized Controlled Trial

using a smart bracelet device; (4) a measurement of IL-1, IL-6, IL-10, and TNF in saliva and (4) modeling of the trend of mucositis for alertness and search of essential parameters of the complications

mucositis
il-1
cancer
propolis
neck cancer
  • 0 views
  • 24 Jan, 2021
  • 1 location
Anakinra Versus Placebo for the Treatment of Acute MyocarditIS

. ANAKINRA, an IL-1 Blocker, is a new treatment that has never been evaluated in myocarditis. The benefit for the patient could be important with a reduction of heart failure and ventricular arrhythmias.

  • 1 views
  • 27 Jan, 2021
  • 3 locations
Adjunctive Sedation With Dexmedetomidine for the Prevention of Severe Inflammation and Septic Encephalopathy

a high mortality and morbidity. The pathophysiology of SE is complex and involves increased levels of inflammatory mediators such as tumor necrosis factor (TNF)-, Interleukin (IL)-1 and IL-6

  • 0 views
  • 07 May, 2021
  • 1 location
Azithromycin in Post Diarrheal Haemolytic and Uremic Syndrome

death. In addition, Stx are also able to enhance the production and the release of pro inflammatory factor (IL-1, TNF, IL-6). Cytokines locally produced by Stx-stimulated cells can amplify the

  • 0 views
  • 23 Jan, 2021
  • 1 location
Dexamethasone for Cerebral Toxoplasmosis

Toxoplasma gondii infects over one third of the global human population. Cerebral toxoplasmosis is the most common opportunistic infection in HIV patients resulting in up to 50% of mortality with proper treatment and 80% without it. The fatality mainly due to the brain edema resulted from the mass effect lesion. …

  • 0 views
  • 15 May, 2021
  • 1 location