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Found 62 clinical trials
Ascorbic Acid and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Lymphoma

This randomized phase II trial studies how well ascorbic acid and combination chemotherapy work in treating patients with lymphoma that has come back (recurrent) or does not respond to therapy (refractory). Ascorbic acid may make cancer cells more sensitive to chemotherapy. Drugs used in chemotherapy, work in different ways to …

salvage therapy
gemcitabine
monoclonal antibody therapy
HIV Infection
monoclonal antibodies
  • 17 views
  • 22 Mar, 2021
  • 7 locations
High-Dose Chemotherapy Given Together With Peripheral Blood Stem Cell Transplant in Treating Patients With Intestinal T-Cell Lymphoma

RATIONALE: Giving chemotherapy before a peripheral blood stem cell transplant stops the growth of cancer cells by stopping them from dividing or by killing them. After treatment, stem cells are collected from the patient's blood and stored. More chemotherapy is given to prepare the bone marrow for the stem cell …

prednisolone
melphalan
methotrexate
cell transplantation
high dose chemotherapy
  • 36 views
  • 07 Nov, 2020
  • 1 location
A Scandinavian Sarcoma Group Protocol for Patients With High-risk Soft Tissue Sarcoma of the Extremities and Trunk Wall

SSG XX is a phase II trial for high-risk soft tissue sarcomas (STS) of the extremities and trunk wall. Prognostic factors (histopathological markers) are used to identify high-risk tumors. SSG XX will evaluate chemo- and radiotherapy given adjuvantly to these patients. In a specified group of patients also preoperatively given …

cancer
doxorubicin
ifosfamide
soft tissue sarcoma
  • 19 views
  • 07 Nov, 2020
  • 1 location
Disulfiram and Cisplatin in Refractory TGCTs.

Non-randomized, open-label, single center trial to assess efficacy (as measured by overall response rate (ORR) by RECIST 1.1 of disulfiram and cisplatin in patients with multiple relapsed/refractory germ cell tumors (GCTs).

platelet count
high-dose chemotherapy
measurable disease
human chorionic gonadotropin
seminoma
  • 15 views
  • 24 Jan, 2021
  • 1 location
Anlotinib Combined With Toripalimab in Refractory and Advanced Soft-tissue Sarcoma

Soft tissue sarcoma (STS) is a relatively rare type of malignant tumor with an incidence of 1-2/100000. For unresectable or widely disseminated advanced STS, a combined clinical trial is the best way to obtain evidence-based medical evidence. Anlotinib, a multi-target receptor tyrosine kinase inhibitor (TKI), is effective for various histological …

undifferentiated pleomorphic sarcoma
measurable disease
soft tissue sarcoma
malignant peripheral nerve sheath tumor
fibrosarcoma
  • 0 views
  • 26 Jan, 2021
  • 1 location
Combination Chemotherapy and Rituximab in Treating Patients With Primary Mediastinal Diffuse Large B-Cell Lymphoma

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. …

prednisolone
prednisone
antibody therapy
methotrexate
monoclonal antibodies
  • 22 views
  • 07 Nov, 2020
  • 5 locations
Concurrent Chemotherapy and Radiation Therapy for Newly Diagnosed Nasal NK Cell Lymphoma

The goal of this clinical research study is to learn if radiation therapy and chemotherapy can help control Stage 1 and/or 2 NK cell lymphoma. The safety of the radiation and chemotherapy combination will also be studied. This is an investigational study. Radiation and chemotherapy are FDA approved and commercially …

etoposide
chemotherapy regimen
filgrastim
dexamethasone
combination chemotherapy
  • 3 views
  • 24 Jan, 2021
  • 1 location
First-line Treatment of Ewing Tumours With Primary Extrapulmonary Dissemination in Patients From 2 to 50 Years

Ewing's sarcoma and related tumours (ESFT) are rare tumours, with a peak incidence in the second decade of life. They start most often from bone, and are characterized by a specific translocation involving the so-called EWS gene. In one patient out of three, the staging procedures detect metastatic tumours at …

  • 19 views
  • 12 Mar, 2021
  • 22 locations
A Study of Different Dosing Schedules of Selinexor in Sarcoma Patients

This is a phase 1, open-label, single centre study of investigational drug selinexor in participants with soft tissue sarcomas that cannot be treated with standard therapies. Selinexor has been given to 3111 participants with cancer to date including 142 sarcoma patients. Early findings have shown that selinexor is effective in …

  • 0 views
  • 04 Apr, 2021
  • 1 location
CYP3A5 Gene as a Risk Factor for Kidney Damage in Young Patients With Cancer Treated With Ifosfamide

RATIONALE: Studying the genes expressed in samples of blood from young patients with cancer treated with ifosfamide may help doctors identify risk factors for kidney damage. PURPOSE

cancer
carboplatin
ifosfamide
  • 28 views
  • 07 Nov, 2020
  • 9 locations