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Found 43 clinical trials
Trial of IPGDP Regimen Chemotherapy in Patients With Extranodal Natural Killer/T-Cell Lymphoma Nasal Type

The first Part: recruiting untreated ENKL patients with extensive stage I or limited stage II disease (only referring to patients with the invasion of Waldeyer's ring and cervical lymph nodes) . Patients are randomly divided into two arms, IPGDP regimen chemotherapy followed by radiotherapy or radiotherapy followed by IPGDP regimen …

  • 8 views
  • 22 Jan, 2021
  • 4 locations
Compare Efficacy of CHOP Versus Fractionated ICED in Transplant-eligible Patients With Previously Untreated PTCL

This study is a Randomized Phase II Study to Compare Efficacy of CHOP versus Fractionated ICED in Transplant-eligible Patients with Previously Untreated Peripheral T-cell Lymphoma.

prednisone
intestinal t-cell lymphoma
enteropathy
large cell lymphoma
panniculitis
  • 10 views
  • 26 Jan, 2021
  • 1 location
Genomics-Based Target Therapy for Children With Relapsed or Refractory Malignancy

The purpose of this study is to evaluate the efficacy and feasibility of combination chemotherapy with target agents according to the result of targeted deep sequencing in pediatric patients with relapsed/refractory solid tumor or AML.

fludarabine
ifosfamide
cytarabine
cancer
etoposide
  • 0 views
  • 24 Jan, 2021
  • 1 location
Ascorbic Acid and Combination Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma or Clonal Cytopenia of Undetermined Significance

This phase II trial studies the effect of ascorbic acid and combination chemotherapy in treating patients with lymphoma that has come back (recurrent) or does not respond to therapy (refractory) or clonal cytopenia of undetermined significance. Ascorbic acid may make cancer cells more sensitive to chemotherapy. Drugs used in chemotherapy, …

monoclonal antibody therapy
oxaliplatin
carboplatin
combination chemotherapy
conjugated bilirubin
  • 17 views
  • 15 Jun, 2022
  • 2 locations
Disulfiram and Cisplatin in Refractory TGCTs. (DISGCT)

Non-randomized, open-label, single center trial to assess efficacy (as measured by overall response rate (ORR) by RECIST 1.1 of disulfiram and cisplatin in patients with multiple relapsed/refractory germ cell tumors (GCTs).

high-dose chemotherapy
high dose chemotherapy
major surgery
mg++
cancer
  • 15 views
  • 08 Feb, 2022
  • 1 location
A Scandinavian Sarcoma Group Protocol for Patients With High-risk Soft Tissue Sarcoma of the Extremities and Trunk Wall (SSGXX)

SSG XX is a phase II trial for high-risk soft tissue sarcomas (STS) of the extremities and trunk wall. Prognostic factors (histopathological markers) are used to identify high-risk tumors. SSG XX will evaluate chemo- and radiotherapy given adjuvantly to these patients. In a specified group of patients also preoperatively given …

cancer chemotherapy
Accepts healthy volunteers
ifosfamide
cancer
doxorubicin
  • 19 views
  • 23 Jan, 2022
  • 2 locations
Temozolomide for Injection Combined With Epirubicin in First-line Treatment of Leiomyosarcoma

This study is a single-center, prospective, one-arm clinical study, which is planned to be carried out in Cancer Hospital of Chinese Academy of Medical Sciences. The patients with locally advanced or metastatic leiomyosarcoma who are inoperable are enrolled, aiming at the effectiveness and safety of temozolomide for injection combined with …

metastasis
cancer chemotherapy
neutrophil count
cancer
measurable disease
  • 0 views
  • 24 Mar, 2022
  • 1 location
Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone Sarcomas (REGOSTA)

This is a randomized, double-blinded, 2 arms study concerning patients with bone sarcoma after the first line therapy. In the first arm, patients will be treated with regorafenib for a maximum of 12 months as maintenance therapy after first line therapy, whereas in the second arm, patients will be treated …

localized disease
Accepts healthy volunteers
immunomodulators
lipase
cancer
  • 1 views
  • 23 May, 2022
  • 4 locations
A Study of Different Dosing Schedules of Selinexor in Sarcoma Patients

This is a phase 1, open-label, single centre study of investigational drug selinexor in participants with soft tissue sarcomas that cannot be treated with standard therapies. Selinexor has been given to 3111 participants with cancer to date including 142 sarcoma patients. Early findings have shown that selinexor is effective in …

neutrophil count
filgrastim
soft tissue sarcoma
cancer
growth factor
  • 0 views
  • 18 Apr, 2022
  • 1 location
International PPB/DICER1 Registry

Pleuropulmonary blastoma (PPB) is a rare malignant neoplasm of the lung presenting in early childhood. Type I PPB is a purely cystic lesion, Type II is a partially cystic, partially solid tumor, Type III is a completely solid tumor. Treatment of children with PPB is at the discretion of the …

sarcoma
solid tumor
cancer chemotherapy
Accepts healthy volunteers
initial diagnosis
  • 37 views
  • 24 Feb, 2022
  • 1 location