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Found 97 clinical trials
A Pilot Study on Intermittent Ibrutinib in Patients With Advanced-phase Chronic Lymphocytic Leukemia (CLL)

Ibrutinib, an inhibitor of Brutons tyrosine kinase (BTK) is approved in CLL as continuous, daily administration of 420 mg orally until progression. Ibrutinib drug costs in health care are

  • 0 views
  • 05 Mar, 2021
  • 9 locations
Venetoclax and Ibrutinib in Treating Participants With High-Risk Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

This phase II trial studies how well venetoclax and ibrutinib work in treating participants with high-risk chronic lymphocytic leukemia/small lymphocytic lymphoma. Drugs used in chemotherapy

cancer
platelet count
chronic lymphocytic leukemia
beta human chorionic gonadotrophin
residual tumor
  • 58 views
  • 08 Apr, 2021
  • 2 locations
Daratumumab and Ibrutinib in Treating Patients With Symptomatic Chronic Lymphocytic Leukemia

This phase Ib trials studies the side effects of daratumumab and ibrutinib and how well they work in treating patients with symptomatic chronic lymphocytic leukemia. Monoclonal antibodies, such

hepatitis b core antibody
beta human chorionic gonadotrophin
ibrutinib
fatigue
fever
  • 45 views
  • 17 Mar, 2022
  • 1 location
A Study of Cirmtuzumab and Ibrutinib in Patients With B-Cell Lymphoid Malignancies

This is a Phase 1b/2 study to investigate the safety and effectiveness of the investigational drug, cirmtuzumab, when given in combination with ibrutinib in patients with B-cell lymphoid

cancer
platelet count
beta human chorionic gonadotrophin
tumor cells
ibrutinib
  • 56 views
  • 08 Nov, 2020
  • 4 locations
Ibrutinib With Radiation and Temozolomide in Patients With Newly Diagnosed Glioblastoma

Safety of combination of ibrutinib and radiation at various dose levels in unmethylated o6-methylguanine-DNA-methyltransferase (MGMT) glioblastoma and study of ibrutinib, temozolomide, and

stereotactic biopsy
cancer
aptt
neutrophil count
combined modality therapy
  • 109 views
  • 21 Mar, 2022
  • 1 location
Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory CLL or Non-Hodgkin Lymphoma

This phase I trial studies the side effects and best dose of pevonedistat when given together with ibrutinib in participants with chronic lymphocytic leukemia or non-Hodgkin lymphoma that has

ibrutinib
b-cell lymphoma
lymphocytosis
fatigue
anemia
  • 12 views
  • 04 Mar, 2022
  • 1 location
Nivolumab and Ibrutinib in Treating Patients With Relapsed or Refractory Central Nervous System Lymphoma

This phase II trial studies the side effects and how well nivolumab and ibrutinib works in treating patients with central nervous system lymphoma that has come back or does not respond to

  • 17 views
  • 08 Feb, 2022
  • 1 location
Ibrutinib and Standard Immuno-Chemotherapy in Younger, High-Risk Patients With Diffuse Large B-Cell Lymphoma (R-CHOEP-brut)

This study will investigate if treatment results obtained with R-CHOEP in young high-risk patients with diffuse large B-cell lymphoma can be further improved by the addition of ibrutinib to this

b-cell lymphoma
platelet count
neutrophil count
ibrutinib
  • 0 views
  • 03 Mar, 2022
  • 10 locations
Study of Ibrutinib in Combination With Revlimid/Dexamethasone in Relapsed/Refractory Multiple Myeloma

This is a registration, open-label phase 1 study of the combination of ibrutinib/lenalidomide:/dexamethasone in women and men with relapsed/refractory multiple myeloma.

platelet count
daratumumab
serum immunoglobulin a
stem cell transplantation
ibrutinib
  • 2 views
  • 13 Apr, 2022
  • 5 locations
A Study of Ibrutinib With Rituximab in People With Untreated Marginal Zone Lymphoma

The purpose of this study is to see if the combination of rituximab and ibrutinib can help people with marginal zone lymphoma who have not received treatment in the past. The study will also

rituximab
ct scan
gastric malt lymphoma
measurable disease
  • 46 views
  • 29 Nov, 2021
  • 13 locations