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Found 108 clinical trials
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Detection of Recurrent Mutations in Waldenstr m's Disease

Waldenstrm's disease (WM) is a rare, low-grade lymphoid hematopathy, accounting for 1 to 2% of malignant hematopathies and mainly affecting the elderly. This disease is characterized by lymphoplasmocyte cells infiltration into the bone marrow and by the production of a monoclonal IgM protein in the serum. This disease is accompanied …

  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients With Previously Untreated Chronic Lymphocytic Leukaemia (CLL)

The aim of this study is to compare the efficacy of continuous ibrutinib monotherapy with fixed-duration venetoclax plus obinutuzumab and fixed-duration ibrutinib plus venetoclax by measuring

  • 1 views
  • 30 Mar, 2021
  • 1 location
None
MALIBU Trial - Combination of Ibrutinib and Rituximab in Untreated Marginal Zone Lymphomas

Single-arm, phase II clinical trial of patients with Extranodal Marginal Zone Lymphoma (EMZL). It is planned to recruit 130 patients. Additional patients with Splenic Marginal Zone Lymphoma (SMZL), up to 30, and Nodal Marginal Zone Lymphoma (NMZL), up to 15, will be included in the trial in order to preliminary …

gastric malt lymphoma
marginal zone lymphoma
lymphadenopathy
rituximab
splenic marginal zone lymphoma
  • 51 views
  • 16 Jun, 2021
  • 54 locations
None
Study of Ibrutinib Combined With Venetoclax in Subjects With Mantle Cell Lymphoma (SYMPATICO)

This Phase 3 multinational, randomized, double-blind study is designed to compare the efficacy and safety of the combination of ibrutinib and venetoclax vs. ibrutinib and placebo in subjects

cyclin d1
renal function tests
venetoclax
ibrutinib
TP53
  • 908 views
  • 01 Aug, 2021
  • 180 locations
None
ASCT After a Rituximab/Ibrutinib/Ara-c Containing iNduction in Generalized Mantle Cell Lymphoma

The primary objective of the the trial is to establish one of three study arms, as future standard based on the comparison of the investigator-assessed failure-free survival.

r-chop
filgrastim
vincristine
ibrutinib
cyclophosphamide
  • 64 views
  • 21 Jan, 2021
  • 80 locations
None
Safety and Efficacy Study of Loncastuximab Tesirine + Ibrutinib in Diffuse Large B-Cell or Mantle Cell Lymphoma

The purpose of this Phase 1/2 study is to evaluate the safety and efficacy of Loncastuximab Tesirine (ADCT-402) in combination with Ibrutinib in participants with Advanced Diffuse Large B-Cell

platelet count
diffuse large b-cell lymphoma
b-cell lymphoma
ibrutinib
gilbert's syndrome
  • 10 views
  • 17 Oct, 2021
  • 31 locations
None
CD19-specific CAR-T Cells in CLL/SLL and DLBCL

(CAR) and manufactured with a new process. CAR-T cells will be investigated in combination with ibrutinib in chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) and as single agent in

  • 22 views
  • 13 Oct, 2021
  • 19 locations
None
Ibrutinib + R-CHOP Followed by Ibrutinib Maintenance

assess the efficacy and the safety of R-CHOP in combination with ibrutinib for 6 cycles followed by ibrutinib maintenance for 18 months in ABC-DLBCL patients achieving at least a PR after the induction

platelet count
growth factor
measurable disease
ibrutinib
cancer
  • 0 views
  • 24 May, 2021
  • 50 locations
None
Ibrutinib + Venetoclax in Untreated WM

This study evaluates the safety and efficacy of Ibrutinib combined with Venetoclax (IVEN) in the treatment of adults diagnosed with Waldenstrom's macroglobulinemia (WM) cancer with a specific

bone marrow procedure
cancer
ibrutinib
measurable disease
neutrophil count
  • 0 views
  • 27 Jan, 2021
  • 1 location
None
RICE-ibrutinib in Relapsed DLBCL

This is a multicentre, open-label, phase II study of ibrutinib 560 mg in combination with R-ICE for treatment of transplant-eligible relapsed/refractory diffuse large B-cell lymphoma.

glomerular filtration rate
lymphoma
b-cell lymphoma
diffuse large b-cell lymphoma refractory
ibrutinib
  • 176 views
  • 21 Jan, 2021
  • 4 locations