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Found 175 clinical trials
Endometrial Cancer Lymphadenectomy Trial (ECLAT)

endometrioid or serous or clear cell EC or carcinosarcomas) will be randomized. In Arm A, a total hysterectomy and bilateral salpingo-oophorectomy and in case of serous or clear cell EC additionally an

  • 30 views
  • 29 Apr, 2022
  • 48 locations
Sentinel Lymph Node Biopsy Versus Pelvic Lymphadenectomy in Early-stage Cervical Cancer (PHENIX/CSEM 010)

The diagnostic value of sentinel lymph node biopsy in early-stage cervical cancer has been well studied. However, there were no randomized controlled study on comparing the long-term outcomes of sentinel lymph node biopsy and conventional procedure. The investigators perform a phase III, randomized controlled trial to determine whether pelvic lymphadenectomy …

cervical cancer stage
adenocarcinoma
cancer
lymphadenectomy
squamous cell carcinoma
  • 3 views
  • 24 Jan, 2021
  • 1 location
Neoadjuvant Chemotherapy + Surgery Versus Surgery in FIGO IB2 and IIA2 Cervical Cancer (SYSGO-003)

To clarify the potential benefits of NACT before radical surgery(RS), we perform a phase III, randomised controlled trial to compare NACT plus RS with RS alone in patients with stages IB2 and IIA2 cervical cancer.

  • 13 views
  • 01 Mar, 2022
  • 1 location
Sentinel Node Biopsy in Endometrial Cancer

Endometrial cancer (EC) is the most common gynaecological cancer. Current treatment of EC typically includes removal of the uterus and to determine the extent of the disease (removal of fallopian tubes, ovaries & if required a lymph node dissection (surgical staging)). While lymph node dissection may be valuable to guide …

  • 0 views
  • 21 Sep, 2021
  • 11 locations
Sentinel Lymph Node Sampling for Patients With Middle-high Risk Endometrial Cancer Confined to the Uterus

Aim To investigate the effect of sentinel lymph node (SLN) sampling on the prognosis of patients with middle-high risk endometrial cancer obviously confined to the uterus before surgery.

  • 0 views
  • 09 Apr, 2022
  • 1 location
Randomized Comparison Between Sentinel Lymph Node Biopsy and Lymph Node Dissection in Early Stage Endometrial Cancer (SELYE)

Through this clinical trial, the investigators aim to verify the usefulness and stability of sentinel lymph node mapping in endometrial cancer of clinical stage I-II.

adenocarcinoma
uterine disease
cancer
hysterectomy
carcinosarcoma
  • 0 views
  • 12 Mar, 2022
  • 1 location
Labor Induction With Oral Versus Vaginal Misoprostol

This study will compare vaginal and oral misoprostol, to determine whether a vaginal misoprostol regimen achieves a higher vaginal delivery rate in a real-world, high-volume setting, and whether this regimen reduces time and oxytocin need on a high-volume Labor and Delivery unit at Parkland Hospital. Our primary hypothesis is that …

prostaglandin
prenatal
induction of labor
misoprostol
oxytocin
  • 35 views
  • 26 May, 2022
  • 1 location
Intravenous Iron for Treatment of Anaemia Before Cardiac Surgery (ITACS)

This randomised double-blind, controlled phase IV trial will compare the efficacy, safety and cost-effectiveness of preoperative IV iron with placebo in patients with anaemia before elective cardiac surgery.

ferric carboxymaltose
iron
  • 227 views
  • 23 Feb, 2022
  • 1 location
Comparison of Cervical CIN II/III Treatment Outcomes With Thermal Ablation Device

The purpose of this academic-industrial partnership will be to compare two thermoablation modalities using devices adapted to low and middle income countries (LMICs) to traditional CO2-based cryotherapy for the treatment of cervical precancer. The investigators will investigate whether the cure rates of cervical intraepithelial neoplasia 2 and more severe diagnoses …

cervical intraepithelial neoplasia grade 2
cervical high grade squamous intraepithelial lesion
cervical dysplasia
cin 3
cryotherapy
  • 0 views
  • 25 Mar, 2022
  • 3 locations
Vaginal NOTES Hysterectomy Versus Vaginal Hysterectomy

the human body for surgery. In 2012, the first vaginal NOTES (vNOTES) hysterectomy was performed. Potential benefits of vNOTES hysterectomy, also called the vaginal assisted NOTES hysterectomy (VANH

  • 0 views
  • 28 Oct, 2021
  • 2 locations