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Found 173 clinical trials
Tailored Adjuvant Therapy in POLE-mutated and p53-wildtype Early Stage Endometrial Cancer

Endometrial cancer(EC) is the 4th most common cancer in women globally. Clinicians struggle to determine 'the best' treatment for endometrial cancers as they are very hard to tell apart under the microscope. Our BC team developed and validated a low-cost practical tool that can reliably distinguish ECs by molecular features. …

  • 01 Feb, 2021
  • 1 location
Uterine Transplant for Women With Absolute Uterine Factor Infertility (AUFI)

Absolute Uterine Factor Infertility (AUFI) is due to congenital or surgical absence of a uterus or the presence of a nonfunctional uterus. Until 2014, the only option for women affected by Absolute Uterine Factor Infertility (AUFI) was adoption or surrogate motherhood. Uterine transplant is a new form of transplant to …

  • 01 May, 2022
  • 1 location
RiLuzole to Reduce Atrial FIbrillatiON A Prospective, Double-Blind, Randomized, Placebo-Controlled Study Using Holter Monitoring (SOLUTION)

Atrial fibrillation (AF) is a growing clinical problem.1 AF is a highly dynamic condition involving episodes of sinus rhythm interspersed with periods of arrhythmia, becoming more difficult to terminate over time. AF carries a substantial cost, morbidity and mortality burden. There are two important approaches to the management of AF: …

  • 09 Apr, 2022
  • 1 location
HIPEC After Initial CRS in Patients Who Have Received NACT

The majority of women diagnosed with ovarian, fallopian tube and primary peritoneal cancer present with advanced stage III and IV disease. Despite aggressive surgery and systemic chemotherapy, the majority of patients will relapse. Five year survival remains only 20-35% for patients diagnosed with bulky stage IIIC and IV cancers. Patients …

cancer of the ovary
fallopian tube
primary peritoneal carcinoma
cancer chemotherapy
  • 14 Feb, 2022
  • 1 location
CREDE Study: Intraoperative Crede Manoeuver Compared to Preoperative Prolapse Reduction Stress Test to Predict Postoperative de Novo Stress Urinary Incontinence (PONSUI) at the Time of Pelvic Organ Prolapse (POP) Surgery

The CREDE pilot randomized study will compare the intraoperative Crede manoeuver (M1) to preoperative prolapse (POP) reduction cough stress test (M2) for the prediction and prevention of PONSUI. The rates of PONSUI and its effect on patient reported outcomes and quality of life will be determined among women with positive …

stress test
brimonidine tartrate ophthalmic solution
  • 26 Mar, 2022
  • 2 locations
Pre- or Postoperative Accelerated Radiotherapy

20 non-metastasized breast cancer patients receiving neoadjuvant chemotherapy will be randomized between preop or postop RT. Patients with clinically suspicious axillary lymph nodes will receive a fine needle biopsy. Patients receiving postop RT will receive neoadjuvant CT followed by surgery (21-28 days after CT) and adjuvant RT starting 28-35 days …

  • 22 Jan, 2021
  • 1 location
Dosimetry of Tc-99m-Tilmanocept

This proposal will use kidney SPECT/CT of Tc-99m-tilmanocept to evaluate the mesangial changes seen in diabetics across the spectrum of kidney disease as well as persons with hypertensive kidney disease, the next most common cause of kidney disease in patients with diabetes. We aim to demonstrate that these different disease …

Accepts healthy volunteers
  • 14 Mar, 2022
  • 1 location
Implementation of Uterine Fibroid Option Grid Patient Decision Aids Across Five Organizational Settings

UPFRONT is a study that aims to use two implementation frameworks - the Consolidated Framework for Implementation Research and the Normalization Process Theory - to guide the implementation of a uterine fibroid patient decision aid, known as Option Grid, at five diverse gynecology settings across the United States. Option Grid …

pelvic pressure
uterine fibroid
  • 04 Oct, 2021
  • 1 location
Hand Forceps vs. Conventional One-hand Technique for Fetal Head Extraction During Cesarean Section (Hand forceps)

The aim of the study is to assess the efficacy and safety of an innovative two-hand (hand forceps) fetal head extraction technique during the transverse cesarean sections (LTCS) by comparing with the conventional one-hand technique used worldwide for centuries. The primary research question of the study is whether two-hand fetal …

cesarean section
  • 27 Apr, 2022
  • 1 location
Adipocytokines in Endometrial Cancer

The number of women diagnosed with uterine cancer continues to rise each year. Since the early 1990s, there has been almost 55% rise in the United Kingdom (UK). 34% of endometrial cancer can be attributed to obesity. In the obese state, the function of adipose tissue deteriorates resulting in a …

  • 07 May, 2021
  • 1 location