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Found 174 clinical trials
Frontline Immunotherapy Combined With Radiation and Chemotherapy in High Risk Endometrial Cancer (FIERCE)

The purpose of this single arm, open label study is to evaluate the feasibility of pembrolizumab combined with radiation administered to the upper part of the vagina (vaginal cuff brachytherapy) followed by three cycles of pembrolizumab and chemotherapy in patients with endometrial cancer.

endometrial carcinoma
  • 28 Feb, 2022
  • 1 location
Megestrol Acetate Plus Rosuvastatin in Young Women With Atypical Endometrial Hyperplasia

To see if megestrol acetate plus rosuvastatin will be superior to reversing the endometrial lesion to a normal endometrium than megestrol acetate alone in patients with atypical endometrial hyperplasia (AEH). Considering the large sample size in RCT, we used Simon two-stage design.

low-density lipoprotein
high-density lipoprotein
adjunctive treatment
atypical endometrial hyperplasia
blood lipid
  • 01 Sep, 2021
  • 1 location
Uterine Manipulation During Minimally Invasive Surgery for Early Stage Endometrial Cancer

This is a prospective, multi-center, randomized non-inferiority phase III study to evaluate if patients undergoing a minimally invasive surgery for early stage uterine cancer have cancer cells in the fluid that is obtained at the time of their surgery when a uterine manipulator is placed versus patients who do not …

  • 09 Sep, 2021
  • 3 locations
Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer

This phase II trial studies the effect of megestrol acetate alone or in combination with metformin in preventing the progression of uterine pre-cancer (endometrial intraepithelial neoplasia) to endometrial cancer. Megestrol acetate is a drug used to block estrogen and suppress the effects of estrogen and androgens. It is the current …

uterine disease
  • 06 May, 2022
  • 5 locations
Pulsed vs Continuous Radiofrequency Neurotomy for Cervical Facet Joint Mediated Pain

Different studies have revealed different success rates and patient satisfaction after cervical facet C-RF. In a study on 32 patients, with 15 months follow up, 25% had complete pain relief (8). Another study had shown mean pain relief of 12.5 months and 11.5 months following a repeat procedure, with an …

  • 04 Jun, 2021
  • 2 locations
Trial of Maintenance With Niraparib- Uterine Serous Carcinoma

Uterine serous carcinoma (USC) accounts for up to 40% of endometrial cancer-related deaths. Patients with USC share many genomic and clinical characteristics with patients who has serous ovarian cancer. The objective of this study is to evaluate the efficacy of maintenance Niraparib regimen in patients with advanced or platinum sensitive …

chemotherapy regimen
uterine carcinoma
ovarian cancer
uterine papillary serous carcinoma
  • 05 Aug, 2021
  • 1 location
Intravenous Dexmeditomidine for Prevention of Spinal Anesthesia Induced Shivering.

Intraoperative and post operative shivering is a common problem encountered in operating rooms and recovery suites. Shivering under spinal anesthesia has an incidence of 40-60%. Shivering is not only uncomfortable for the patient; additionally it increases minute oxygen consumption, subjecting the patient to a higher risk of cardiovascular complications. A …

Accepts healthy volunteers
  • 23 May, 2022
  • 1 location
Pudendal Enhancement of Enhanced Recovery After Surgery (ERAS) for Reconstructive Surgery (PEERS)

Patients will undergo their vaginal reconstructive surgery in the usual manner, but will also be randomly assigned on the day of surgery to either receive the extra injection of numbing medication at the onset of surgery or not. The chances they will be assigned to the additional injection is 50%. …

nerve block
local anesthesia
local anesthetics
  • 18 Feb, 2022
  • 1 location
Cost-utility of Ambulatory Surgery in the Management of Endometrial Cancer(AMBU-ENDO) (AMBU-ENDO)

To date, cost-utility, safety, and feasibility of ambulatory surgery versus traditional pathway in the management of endometrial cancer have never been prospectively assessed. The investigators hypothesize that ambulatory surgery versus standard pathway in the management of endometrial cancer is both safe, feasible and may impact on patient health-related quality of …

  • 23 Feb, 2022
  • 1 location
Prospective Controlled Randomized Multicentric Study on the Management of the Vesical Catheter in Colon Surgery.

INTRODUCTION: Recommendations for peroperative bladder catheterization remain a controversial issue since it is a procedure that is not without complications. Most of the current suggestions derive from open surgery data that have been extrapolated to Enhanced Recovery After Surgery (ERAS) or Fast-Track programs ranging between 24-48 hours. The objective of …

enhanced recovery after surgery
open surgery
colon operation
  • 23 Nov, 2021
  • 1 location