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Found 268 clinical trials
Development of Clinical and Biological Database in Colorectal Cancer (CIRCUS)

Creation of circulating cancer cell-lines and caracterisation of these cell-lines which will be collected before any treatment in patients with metastatic colon adenocarcinoma

metastatic colorectal cancer
  • 19 Feb, 2022
  • 1 location
Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) Antagonists

Background Chronic granulomatous disease (CGD) affects the immune system. People with CGD are more likely to get infections. Drugs can help control infections, but these treatments can cause side effects including kidney failure and deafness. Stem cell transplants can cure CGD, but these don t always work. Objective To find …

  • 04 Oct, 2022
  • 1 location
Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane

The purpose of this protocol is to determine the effect of two clinically applicable Dexmedetomidine dosages (0.5mcg/kg and 1mcg/kg) on the minimum alveolar concentration (MAC) of Sevoflurane in children between the age ranges of: 1-6 months; 6-12 months of age and 12 months-36 months years of age.

Accepts healthy volunteers
  • 27 Apr, 2022
  • 1 location
Vascular Occlusion for Optimizing Functional Improvement in Patients With Knee Osteoarthritis

Recent research in strength training physiology revealed that implementation of occlusion garments around the proximal aspect of the lower limbs in combination with low load strength training causes a reduced blood flow and thus providing a high metabolic stimulus, causing a training effect similar to high load training. This study …

  • 18 Aug, 2021
  • 1 location
The Impact of the Vasodilator, Sildenafil, on the Pulmonary Circulation During Exercise in Healthy Trained and Untrained Humans

There is emerging evidence suggesting that the pulmonary vasculature and right heart may play a role in the limitation of exercise capacity in healthy individuals. It is well established that aerobic training improves cardiovascular function. While the pulmonary system is integral to the function of the cardiopulmonary system, it has …

Accepts healthy volunteers
  • 15 Oct, 2022
  • 1 location
Atomization vs. Nebulization for Airway Topicalization During Awake Nasotracheal Fiberoptic Intubation

Intubation of difficult airway is a challenge for anesthetist. There many causes of difficult airway, and previous studies concluded that awake fiber-optic intubation (AFOI) is the gold standard for the management of these patients. Several studies showed that airway nerve blocks provide rapid and deep airway anesthesia, however, due to …

  • 12 Sep, 2023
  • 1 location
DAHANCA 30: A Randomized Non-inferiority Trial of Hypoxia-profile Guided Hypoxic Modification of Radiotherapy of HNSCC. (DAHANCA30)

, nimorazole is added the radiotherapy of most HNSCC, as it has not previously been possible to discriminate more hypoxic tumours from less hypoxic tumours. A hypoxia gene profile has shown to

squamous cell carcinoma
head and neck cancer
neck cancer
  • 23 Feb, 2022
  • 1 location
Effect of Allopurinol for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome (ALBINO)

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and

xanthine oxidase inhibitor
  • 03 Mar, 2022
  • 10 locations
Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol In Overweight Or Obesity Patients (SpO2)

conduct a Multicenter, Randomized, Open-label, Propofol-controlled Study to Evaluate the incidence of hypoxia and severe hypoxia during Gastroenterological Endoscope sedated with CiProfol in Overweight or

body mass index
  • 01 Oct, 2023
  • 3 locations
Multisite Tissue Oxygenation Guided Perioperative Care in Cardiac Surgery

The BOTTOMLINE-CS trial is an international, open, single-center, pragmatic, randomised controlled trial to investigate whether multisite tissue oxygen saturation monitoring-guided perioperative care reduces composite complications within 30 days of randomization in off-pump coronary artery bypass grafting.

  • 13 Nov, 2021
  • 1 location