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Found 88 clinical trials
Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia

Hypoxic-Ischemic Encephalopathy (HIE) occurs in 20 per 1000 births. Only 47% of neonates treated with the state of the art therapy (induced systemic hypothermia) have normal outcomes. Therefore

deficit
cytokines
base deficit
hypothermia
hypoxia
  • 108 views
  • 02 Jun, 2022
  • 2 locations
Neuroprotective Effect of Autologous Cord Blood Combined With Therapeutic Hypothermia Following Neonatal Encephalopathy

This study examines the effect of cord blood in the treatment of newborn infants with neonatal encephalopathy in combination with hypothermia, which is the standard treatment for this condition

hypothermia
seizure
acidosis
encephalopathy
  • 14 views
  • 22 Jan, 2022
  • 1 location
Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation

in patients undergoing liver transplantation with ex-vivo liver preservation using static cold storage (SCS) followed by hypothermic oxygenated machine perfusion (HOPE) versus SCS only.

carcinoma
  • 0 views
  • 22 Mar, 2022
  • 1 location
Amikacin Pharmacokinetics to Optimize Dosing Recommendations in Neonates With Perinatal Asphyxia Treated With Hypothermia

therapeutic hypothermia and to provide amikacin dosing recommendations, which will be validated prospectively. For this purpose, we aim to first collect retrospective data on amikacin available in neonates

  • 0 views
  • 08 May, 2021
  • 1 location
Dual Hypothermic Oxygenated Machine Perfusion in Liver Transplantation Using Allografts From Donors After Brain Death

This will be a randomized study on the effects of hypothermic oxygenated machine perfusion in patients undergoing liver transplantations from donors after brain death with allocation of patients

  • 0 views
  • 19 Apr, 2021
  • 1 location
Adjunct Targeted Temperature Management in Acute Severe Carbon Monoxide Poisoning

hypothermia or normothermia combined with hyperbaric oxygen therapy (HBO).

  • 0 views
  • 22 Dec, 2021
  • 2 locations
The Efficacy of External Warming During Laparoscopic Bariatric Surgery

External warming is routinely used in general surgery to offset the deleterious effects of hypothermia. It entails deployment of a disposable, external heating blanket attached to a regulated

bariatric surgery
anesthesia
  • 17 views
  • 02 Mar, 2022
  • 1 location
Topical Ice-therapy for Intravitreal Injections

Purpose: To examine the difference in patient's pain experience in the setting of intravitreal anti-VEGF injections with pretreatment of topical ice-therapy compared with no-ice.

Accepts healthy volunteers
  • 0 views
  • 22 Jul, 2022
  • 1 location
Impact of Intraoperative Instillation of Normothermal Saline on the Prevention of Intraoperative Hypothermia and Perioperative Morbidity of Prostatic Enucleation With Holmium Laser (THERMHOLEP)

average body temperature of the patient (37°C). Thus, and by heat exchange, it often results in per and postoperative hypothermia, which is all the more frequent and profound the longer the duration of

benign prostatic hyperplasia
local anesthesia
hyperplasia
anesthesia
  • 0 views
  • 08 Jul, 2022
  • 1 location
Optimising the Duration of Cooling in Mild Encephalopathy (COMET)

Phase II randomised control trial of whole body cooling in mild neonatal encephalopathy.

  • 11 views
  • 11 Aug, 2022
  • 6 locations