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Found 112 clinical trials
Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 3

This is a double-blind, randomized, two x two crossover (aprepitant vs placebo) during both initiation of Entresto, LCZ696, (50 mg dose) and at steady-state of Entresto (200 mg bid dose or the highest tolerated dose).

heart failure
enalapril
angiotensin ii receptor antagonists
natriuretic peptide
ejection fraction
  • 0 views
  • 15 Jun, 2022
  • 1 location
Trendelenburg as a First-line Intervention in Critically Ill, Sedated, Invasively Mechanically Ventilated, Hypotensive Patients (Trend)

A pilot randomized controlled trial to evaluate the efficacy and safety of Trendelenburg position in critically ill patients with hypotension, mainly patients with septic shock and post operative vasoplegia. The main aim is to assess whether Trendelenburg position can improve organ function through a reduction in the need of fluid …

  • 0 views
  • 24 Mar, 2022
The Hypotensive Effects of Home-Based Isometric Handgrip Training in Older Adults With Pre-Hypertension and Hypertension - The HoldAge Trial

New data suggests that isometric handgrip training (IHT) might become a novel tool in the treatment of hypertension. The main purpose of this research project is to evaluate the effects of home-based IHT on ambulatory blood pressure in older adults with pre-hypertension and hypertension. Eighty-four older adults with pre-hypertension and …

prehypertension
hypotensive
hypertension
stiffness
  • 0 views
  • 29 Jun, 2022
  • 10 locations
Comparison of Vasopressor Boluses for Management of Hypotension After Spinal Anesthesia

In this study the investigators will compare the efficacy and side effects of two doses of norepinephrine bolus (6 mcg and 10 mcg) in management of maternal hypotensive episode after

  • 3 views
  • 15 Feb, 2022
  • 1 location
MINIject (MINI SO627) in Patients With Open Angle Glaucoma Using Single Operator Delivery Tool

The study will assess safety and performance in patients with open-angle glaucoma uncontrolled by topical hypotensive medications who had previously been implanted with a MINIject glaucoma

  • 0 views
  • 02 Aug, 2021
  • 2 locations
MAnnitol for Blood Pressure Stability in HemoDialysis (MAP-HD)

This proposal will measure the effects of mannitol administration versus placebo in hypotensive-prone, adult, maintenance hemodialysis patients with respect to changes in patient symptoms and

  • 0 views
  • 15 May, 2022
PSLT Compared to Prostaglandin Analogue Eye Drops

This study aims to compare the efficacy of PSLT and the topical use of prostaglandin-like hypotensive eye drops in the treatment of ocular hypertensive or glaucomatous patients in decreasing

tartrate
intraocular pressure
brimonidine
glaucoma
hypotensive
  • 0 views
  • 25 Mar, 2022
  • 1 location
Premedication With Labetalol Versus Metoprolol for Controlled Hypotension During Endoscopic Nasal Surgeries

compare the safety and efficacy of oral labetalol versus oral metoprolol as a premedication for controlled hypotensive anesthesia during endoscopic nasal surgeries. Patients and Methods: This is a

  • 0 views
  • 30 Jun, 2022
  • 1 location
Management of Shock in Children With SAM and Diarrhea

randomized trial will generate evidence whether inotrope and vasopressor or blood transfusion should be selected for severely malnourished children having hypotensive shock and who failed to respond to WHO

dopamine
  • 0 views
  • 07 Apr, 2022
  • 1 location
Two Norepinephrine Rescue Bolus Doses for Management of Severe Post-spinal Hypotension During Elective Cesarean Delivery

lead to failed management and prolonged hypotensive episode, whereas a higher dose might lead to reactive hypertension and/or bradycardia, which is sometimes severe. Therefore, determining the optimum

  • 0 views
  • 11 May, 2022
  • 1 location