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Found 79 clinical trials
Accelerated Stress CMR in Coronary Artery Disease

This study will evaluate the diagnostic performance of an accelerated stress CMR protocol, comparing it with that of standard CMR assessment.

chest pain
  • 25 Mar, 2022
  • 1 location
Experience of Relatives and Intensive Care Units Caregivers of Controlled Donation After Circulatory Death (CARE-M3)

Controlled donation after circulatory death (cDCD) refers to organ donation (OD) from patients whose death is defined using circulatory criteria and from whom circulatory death occurs after a planned withdrawal of life-sustaining therapies (WLST) in intensive care units (ICUs). During cDCD, the patient is still alive while OD process is …

  • 19 Apr, 2022
Change in Brain Perfusion During Induction of General Anesthesia

Arterial hypotension during general anesthesia remains a factor of poor outcomes, increases the risk of myocardial infarction, acute kidney injury and 1-year mortality. Furthermore, arterial hypotension may also decrease cerebral perfusion contributing to worsen neurological outcome. It seems necessary to monitor cerebral perfusion during anesthesia and to define individual dynamic …

  • 07 Mar, 2021
  • 1 location
Use of Electrophysiological Markers to Predict Post-operative Cognitive Dysfunction

As the population ages and medical progress is made, many elderly patients that previously would not have been candidates for surgery are now undergoing operations. In this group of older patients, brain dysfunction after anesthesia and surgery, naming post-operative cognitive dysfunction, is well known. Post-operative cognitive dysfunction (POCD) is a …

Accepts healthy volunteers
  • 02 Jan, 2022
  • 1 location
Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury

Acute brain injury due to traumatic brain injury (TBI), intracerebral haemorrhage (ICH), and aneurysmal subarachnoid haemorrhage (SAH) carries a high morbidity and mortality, in part due to the development of secondary brain injury. The mechanisms behind secondary brain injury are incompletely understood, but oxidative/nitrosative stress and disturbances in the metabolism …

acute brain injuries
traumatic brain injury
  • 24 Oct, 2021
  • 1 location
The Correlation Between Immunological Reaction of the Seminal Fluid in the Mother's Blood and Pregnancy Complications

It is known that if there isn't an efficient exposure to the paternal antigens before conception, there is an increased risk for the pre-eclampsia (PE) cascade and other pregnancy complications to take place. It is possible that maternal immune system that doesn't develop tolerance to the paternal antigens that the …

Accepts healthy volunteers
toxemia of pregnancy
foetal complications
  • 11 May, 2022
  • 1 location
Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension

In critically ill patients with liver disease like cirrhosis or ACLF, fluid therapy needs to be instituted after identification of patients who will be fluid responsive and initiate appropriate inotropes early to prevent the mortality associated with fluid overload. The parameters and methodology used for assessing fluid responsiveness have been …

liver disease
systolic blood pressure
  • 06 Jun, 2022
  • 2 locations
Cerebral Monitoring and Post-operative Delirium and Outcomes (Techno-5)

Brain monitoring using near-infrared spectroscopy (NIRS) started in 2002 in the operating room of the Montreal heart Institute (MHI). This was followed by the use of somatic NIRS in 2010, transcranial Doppler in 2015 and processed electroencephalogram (pEEG) using Sedline (Masimo, Irvine CA) in 2017. The introduction of those modalities …

  • 07 Oct, 2022
  • 1 location
The Carotid Artery Multi-modality Imaging Prognostic (CAMP) Study

Carotid artery disease is a main cause of ischemic stroke and vascular dementia, and a highly prevalent disease. There is uncertainty about the optimal management of patients with serendipitously or systematically detected asymptomatic carotid artery disease, due to the paucity of information on the predictive features of serious vascular events. …

  • 27 Jan, 2021
  • 1 location