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Found 79 clinical trials
Hypercapnia in Orthostatic Hypotension

The Autonomic (or "automatic") Nervous System (ANS) regulates internal processes, including control of heart rate and blood pressure (BP). When someone stands, and gravity tries to pull blood away from the brain, the ANS works to maintain BP and brain blood flow. Neurogenic Orthostatic Hypotension (NOH) occurs when our "fight-or-flight" …

light-headedness
nervous
Accepts healthy volunteers
  • 0 views
  • 08 Apr, 2022
  • 1 location
Inhaled Nitric Oxide (iNO) in Idiopathic Pulmonary Fibrosis (IPF).

Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease marked by reduced exercise capacity and activity-related breathlessness (commonly termed dyspnea). Our previous work has shown that dyspnea during exercise is associated with an increased drive to breathe (inspiratory neural drive; IND). However, little work has been done to understand the …

nitric oxide
cardiopulmonary exercise testing
idiopathic pulmonary fibrosis
Accepts healthy volunteers
dyspnea
  • 0 views
  • 06 May, 2022
  • 1 location
Inhaled Nitric Oxide (iNO) in Post-Pulmonary Embolism (Post-PE)

Following acute pulmonary embolism (PE), up to a third of patients develop post-PE syndrome described as having persistent breathlessness (dyspnea), impaired exercise capacity, and a reduced quality of life. The post-PE syndrome includes patients with chronic thromboembolic pulmonary hypertension (CTEPH), patients with chronic thromboembolic disease (CTED) those with an obstruction …

acute pulmonary embolism
nitric oxide
dyspnea
FIO2
  • 0 views
  • 07 Oct, 2022
  • 1 location
REmote Cardiac MOnitoring of At-risk SYNCope Patients After Emergency Department Discharge - A Multicenter Randomized Controlled Trial: REMOSYNCED (REMOSYNCED)

Syncope (fainting) is a common reason for emergency department (ED) presentation. Fainting can be caused by heart conditions such as irregular heart rhythm (arrhythmia) that can be life-threatening, structural heart problems, or serious conditions not related to the heart. The standard or usual treatment for the majority of patients at-risk …

  • 0 views
  • 24 Oct, 2022
  • 1 location
PERSEUS-PS Randomized Controlled Trial (PERSEUS-PS)

The PERSEUS protocol is a new approach to the resuscitation of highly monitored patients with cardiac arrest. It aims at the optimization of all the available physiological parameters and the full exploitation of both the "cardiac pump" and "thoracic pump'. This protocol will help to titrate chest compressions, ventilation, and …

resuscitation
Accepts healthy volunteers
vasoconstrictor
  • 0 views
  • 25 Apr, 2022
  • 1 location
Effectiveness of Remote Ischemic Preconditioning for Prevention of Contrast Induced Acute Kidney Injury in Patients Undergoing Coronary Angiograms. (RIP-CI-AKI)

The use of imaging is increasing in clinical practice, either for diagnosis or intervention. In these imaging processes, contrast medium (CM) is widely used. However, CM administration can induce contrast-induced nephropathy (CI-AKI). CI-AKI is the third most common cause of renal insufficiency, and its incidence varies from 2% to 50% …

  • 0 views
  • 02 May, 2022
  • 1 location
Effects of Nitrate-rich Beetroot Juice in Pregnant Women With High Blood Pressure (NITBEETPE)

BACKGROUND: Preeclampsia (PE) is a serious syndrome that affects 3-7% of all pregnant women. PE is characterized by hypertension and kidney problems after the 20th week of pregnancy and is associated with an increased risk of serious cardiovascular complications including death in both mother and fetus. The underlying disease mechanisms …

nitric oxide
Accepts healthy volunteers
renal function
cardiovascular complications
hypertension
  • 0 views
  • 25 Mar, 2022
  • 1 location
Pacemaker Effect With Closed Loop Sensor in Neuromodulated Syncope Refractory to Medical Therapy

Vasovagal syncope is an entity frequently in the emergency services, its treatment includes pharmacological and non-pharmacological measures, and in some severe cases, requires the implantation of cardiac stimulation devices, specifically, those pacemakers that have closed-loop sensors (CLS). This research is an intervention study, multi-institutional, randomized and double blind that will …

  • 0 views
  • 12 Sep, 2021
  • 2 locations
BUN/Cr-based Hydration Therapy to Improve Outcome of Patients With Acute Ischemic Stroke

English Synopsis I. Title of Study: A trial of BUN/Cr-based hydration therapy to reduce stroke-in-evolution and improve short-term functional outcomes for dehydrated patients with acute ischemic stroke-version 2. II. Indication: We use blood urea nitrogen (BUN)/blood creatinine (Cr) ratio15 as a dehydration biomarker. This clinical trial aims to determine if …

  • 0 views
  • 24 Nov, 2021
  • 1 location
Multimodal Monitoring of Cerebral Autoregulation After Pediatric Brain Injury

Various methods have been studied to evaluate autoregulation. However, there is currently no universally accepted technique to assess integrity of the cerebral autoregulation neurovascular system. In the last decade, significant progress has been achieved in developing methods to assess cerebral autoregulation by quantifying cross-correlation between spontaneous oscillations in CBF or …

cardiac arrest
Accepts healthy volunteers
traumatic brain injury
stroke
transcranial doppler ultrasonography
  • 5 views
  • 23 Mar, 2022
  • 1 location