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Found 79 clinical trials
DCS Study in Extremely Premature Newborns

hypoperfusion on the preterm brain during the first days of life, and their relationship with incidence of intraventricular hemorrhage (IVH). We aim to recruit 100 premature infants to obtain data to:

cerebral blood flow
cerebral perfusion
intraventricular hemorrhage
  • 05 Mar, 2022
Hemodynamic OptimizaTion in Sitting POsition Surgery Trial (HOTSPOT)

different positions assumed by the patient during surgery. Since severe hypotensive phenomena are connected with cerebral hypoperfusion and are associated with negative outcomes, close monitoring of blood

  • 04 Oct, 2022
  • 1 location
Aerobic Exercise for Older Adults at Increased Risk of Alzheimer's Disease and Related Dementias (BIMII)

hypoperfusion and dysregulation of cerebral blood flow are thought to be important pathophysiological factors. The investigators' central hypothesis is that regular aerobic exercise mitigates age-related

mild cognitive impairment
body mass index
alzheimer's disease
cognitive decline
cognitive impairment
  • 25 Feb, 2022
  • 1 location
Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia.

The purpose of this study is to investigate the suitable infusion dose of norepinephrine for prophylaxis against postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.

  • 18 Dec, 2021
  • 1 location
NORepinephrine-Maintaining-individuaALIZEd Blood Pressure

This study compares the effect of individualized vs standard blood pressure management on postoperative myocardial injury in high-risk patients undergoing non-cardiac surgery by measuring the hs-cTnT levels. Continuous norepinephrine infusion is used to target a mean pressure of greater than 65mmHg and a systolic pressure less than 160mmHg in the …

  • 08 Jul, 2022
  • 1 location
tSCI Contrast Enhanced Ultrasound Study

Patients with traumatic spinal cord injury (tSCI) often suffer from spinal cord swelling inside the thecal sac, which contains the spinal cord and surrounding fluid, leading to increased pressure on the spinal cord tissue and decreased spinal cord blood flow at the site of injury. The combination of increased pressure …

  • 15 Feb, 2022
  • 1 location
Structural and Functional Cerebral Changes After Infusion of ATP Sensitive Potassium Channel Opener Levcromakalim.

The aim of the present study to investigate whether Opening of KATP channels causes migraine pain by activation of meningeal nociceptors and ascending trigeminal nociceptive pathways. Opening of KATP channels causes migraine aura by induction of CSD.

  • 22 Oct, 2022
  • 1 location
Cardiac Output Response to Vasopressin Infusion In Abdominal Surgery Patients Under Mechanical Ventilation

In this study, the investigators propose to explore the hemodynamic variations induced by vasopressin and its influence on cardiac output, mean systemic pressure, and venous return resistance measured through cardiopulmonary interactions, according to the approach proposed by Guyton, in patients undergoing major abdominal surgeries.

  • 07 Jul, 2021
  • 1 location
The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in COPD (iNO)

Chronic Obstructive Pulmonary Disease (COPD) is a lung disorder commonly caused by smoking, which makes breathing more difficult. When COPD patients exercise, they are not efficient breathers and this leads to serious breathing difficulties, which often causes these patients to stop exercise at low intensities. Even though patients with a …

pulmonary disease
Accepts healthy volunteers
  • 10 Oct, 2022
  • 1 location
Fluid unLoading On Weaning (FLOW)

The purpose of this study is to determine if testing preload responsiveness, the normal physiologic state that means that changes in preload determine changes in cardiac output, allows an earlier and physiologically safer weaning from mechanical ventilation in critically ill patients with fluid overload, when compared to a strategy of …

  • 12 Sep, 2021
  • 1 location