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Found 79 clinical trials
Management of Angiotensin Inhibitors During the Perioperative Period (AIPOP)

This is a multicenter randomized clinical trial to determine the effect of continuation versus withdrawal of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) in the perioperative period on postoperative complications.

hypertension
postoperative complication
  • 0 views
  • 22 Mar, 2022
  • 6 locations
Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients (CONFIDENCE)

Timely recognition and treatment of fluid overload can expedite liberation from invasive mechanical ventilation in intensive care unit (ICU) patients. Lung ultrasound (LUS) is an easy to learn, safe, cheap and noninvasive bedside imaging tool with high accuracy for pulmonary edema and pleural effusions in ICU patients. The aim of …

  • 3 views
  • 23 Mar, 2022
  • 1 location
GLP-1 and Hyperoxia for Organ Protection in Heart Surgery (GLORIOUS)

Patients undergoing open heart surgery are at risk of suffering damage to the heart, brain and kidneys. This study is designed as a 2-by-2 randomized clinical trial with the purpose of investigating the organ protective effects of the glucagon-like-peptide-1 (GLP-1) agonist Exenatide versus placebo and restrictive versus liberal oxygenation during …

percutaneous coronary intervention
heart disease
ischemic heart disease
exenatide
glp-1
  • 40 views
  • 27 Jan, 2022
  • 1 location
Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion: a Randomized Controlled Multi-center Trial (ADAPT)

. Although the prognostic role of septic cardiomyopathy remains debated, sepsis-induced left ventricular (LV) systolic dysfunction may be severe and associated with tissue hypoperfusion, while it appears to

norepinephrine
resuscitation
hypoperfusion
vasoconstrictors
levosimendan
  • 0 views
  • 15 Oct, 2022
  • 15 locations
Treatment of Hyperlactatemia in Acute Circulatory Failure Based on Analysis of CO2: a Prospective Randomized Superiority Study (The LACTEL Study)

The management of a patient with shock is based on improving tissue oxygenation through hemodynamic optimization. Lactate is a marker of tissue hypoperfusion commonly used in the ICU. In

  • 0 views
  • 02 Dec, 2021
  • 1 location
Treating Postictal Symptoms Using Ibuprofen and Nifedipine

This study will evaluate the effect of ibuprofen or nifedipine on post-seizure hypoperfusion and neurological deficits in patients with epilepsy. One group will receive ibuprofen, another will

  • 1 views
  • 11 May, 2021
  • 2 locations
Effect of Dobutamine on Hepatic Blood Flow During Goal-directed Hemodynamic Therapy

Maintaining adequate perfusion pressure and oxygen supply is essential for organ survival. Splanchnic hypoperfusion during the perioperative period in abdominal surgery may result in mucosal

  • 3 views
  • 18 Jul, 2021
  • 1 location
Angiotensin II in General Anesthesia

Hypotension in adult patients undergoing general anesthesia is common. This can lead to hypoperfusion of vital organs, organ damage, and states of increased metabolic duress. This may be worse

ace inhibitor
anesthesia
angiotensin
antihypertensive drugs
essential hypertension
  • 0 views
  • 13 Jun, 2022
  • 1 location
Effect of Inhalatory Sedation in Subarachnoid Hemorrhage (INSPIRE)

vasodilatory effect on territories with different cerebrovascular reactivity aggravating the phenomena of distrectual hypoperfusion (theft theory).

  • 0 views
  • 25 May, 2022
  • 1 location
IMMPRES: Intraoperative Monitoring & Management to Reduce Stroke

reduce perioperative stroke. The central hypothesis is that perioperative stroke occurs from emboli in the setting of significant hypoperfusion resulting in ischemia, which leads to infarction. The

ischemia
hypoperfusion
  • 0 views
  • 27 Dec, 2021
  • 1 location