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Found 65 clinical trials
Study on Early Brain Injury Mechanism and Comprehensive Intervention of VCI

clinical research cohort of VCI to focus on three key issues in VCI research and clinical practice: (1) the theory that cerebral hypoperfusion may be an important pathological basis for the occurrence and

  • 19 Aug, 2021
  • 1 location
Cardiac Output Optimization on Postoperative Complications in Major Hepatic Surgery (OPTILIVER)

exposes the risk of organ hypoperfusion due to low cardiac flow, secondary to hypovolaemia, which may lead to ischemic situations favoring the onset of postoperative complications. On the other hand, the

  • 09 Apr, 2022
  • 1 location
Ilomedin in Septic Shock With Persistent Microperfusion Defects (I-MICRO) (I-MICRO)

been observed in experimental sepsis using Ilomedin. Our group has furthermore reported that administration of Ilomedin in patients with refractory septic shock (peripheral hypoperfusion) resulted in a

  • 07 Oct, 2022
  • 1 location
Modulation of Microbiota Metabolism in Cardiac Surgery Patients With at High Risk of Postoperative Multiple Organ Dysfunctions (MMMMODCS)

An imbalance in the microbiota (most often intestinal) largely determines the onset of a disease state, and often a critical state. Cardiac surgery accompanied by heart failure and hypoperfusion

  • 14 Oct, 2022
  • 1 location
Benefit of Amlodipine in HRT Cycle for Frozen Embryo Transfer in the Correction of Uterine Pulsatility Index (AMLODIP)

Embryo implantation depends on two main factors: embryo grading quality and endometrial receptivity.Numerous tools have been suggested to evaluate these two factors. Measurement of the pulsatility index (PI) of the uterine arteries is associated with extremely low chances of pregnancy when it is high, especially higher than 3. A pilot …

Accepts healthy volunteers
  • 04 Oct, 2022
  • 1 location
Intravenous Amino Acid Therapy for Kidney Protection in Cardiac Surgery. (PROTection)

principles and the ability to intervene before the injury has begun. Although the etiology of AKI in cardiac surgery is multifactorial, renal hypoperfusion is believed to play a major role in this

acute renal failure
kidney injury
critical illness
crystalloid solutions
  • 12 Jul, 2022
  • 16 locations
Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery

Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. It is now realized that intraoperative hypotension is an important risk factor for the development of AKI. In a recent randomized controlled trial of patients undergoing major noncardiac surgery, intraoperative individualized blood-pressure management …

renal injury
acute kidney injuries
heart surgery
coronary artery bypass graft
  • 14 Feb, 2022
  • 1 location
Remote Ischemic Conditioning in Patients With Acute Stroke (RESIST) (RESIST)

Our primary aim is to investigate whether remote ischemic conditioning (RIC) as an adjunctive treatment can improve long-term recovery in acute stroke patients as an adjunct to standard treatment.

adjunctive treatment
limb ischemia
acute stroke
  • 26 Mar, 2022
  • 4 locations
Management of Angiotensin Inhibitors During the Perioperative Period (AIPOP)

This is a multicenter randomized clinical trial to determine the effect of continuation versus withdrawal of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) in the perioperative period on postoperative complications.

postoperative complication
  • 22 Mar, 2022
  • 6 locations
Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients (CONFIDENCE)

Timely recognition and treatment of fluid overload can expedite liberation from invasive mechanical ventilation in intensive care unit (ICU) patients. Lung ultrasound (LUS) is an easy to learn, safe, cheap and noninvasive bedside imaging tool with high accuracy for pulmonary edema and pleural effusions in ICU patients. The aim of …

  • 23 Mar, 2022
  • 1 location