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Found 58 clinical trials
Very Large Sizes in Adolescents : Tibial and Femoral EPIphysiodesis

The very large sizes can be very disabling and at the origin of a difficult psychological experience. Some families are in demand for a growth-curbing treatment. Currently, only hormonal treatments are offered in France but they are at the origin of many side effects. Northern European countries applied a surgical …

  • 0 views
  • 17 Mar, 2021
  • 5 locations
A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men

This is a blinded and placebo-controlled study of topical testosterone replacement therapy (TRT) in symptomatic hypogonadal men with increased risk for cardiovascular (CV) disease.

testosterone topical
testosterone level
testosterone
replacement therapy
serum testosterone
  • 16823 views
  • 08 Apr, 2021
  • 431 locations
Hypogonadotropic Hypogonadism in Obese Young Males

Obesity can lead to low testosterone concentrations in young men. This study will study the effects of low testosterone in those men and the result of treating them with clomiphene.

testosterone level
testosterone
clomiphene
secondary hypogonadism
klinefelter syndrome
  • 63 views
  • 26 Jan, 2021
  • 1 location
Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism

The goal of this study is to develop novel treatments for patients with a condition called hypogonadotropic hypogonadism (HH) through the use of exogenous kisspeptin.

  • 0 views
  • 04 Mar, 2021
  • 1 location
Efficacy and Safety of Long Term Use of hCG or hCG Plus hMG in Males With Isolated Hypogonadotropic Hypogonadism (IHH)

This study will evaluate the efficacy and safety of long term use of hCG alone or hCG plus hMG in the treatment of male patients with isolated hypogonadotropic hypogonadism (IHH). One third of

testosterone level
testosterone
hormone levels
serum fsh level
klinefelter syndrome
  • 110 views
  • 24 Jan, 2021
  • 1 location
Neuropeptides in Human Reproduction

The investigators are seeking healthy volunteers and volunteers with reproductive disorders for the study of the role of dynorphin in the reproductive system. Dynorphin is a naturally occurring opioid hormone that is blocked by naloxone. We hypothesize that naloxone, by blocking dynorphin, will stimulate production of GnRH and kisspeptin, 2 …

hypogonadism
screening procedure
klinefelter syndrome
thyroid stimulating hormone
gonadotropin
  • 98 views
  • 27 Jan, 2021
TESTO: Testosterone Effects on Short-Term Outcomes in Infants With XXY

This research study in infant males with Klinefelter syndrome (47,XXY) will learn more about the effect of testosterone on early health and development. The study is a total of three visits over

amniocentesis
testosterone level
screening procedure
testosterone
hormone levels
  • 156 views
  • 23 Jan, 2021
  • 1 location
Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling

The investigators are looking for subjects to complete a study on the role of kisspeptin in the reproductive system. Kisspeptin is a naturally occurring hormone in humans that tells the body to produce other reproductive hormones. However, giving someone a continued amount of kisspeptin over a period of time can …

estradiol
testicular
screening procedure
secondary hypogonadism
reproductive hormones
  • 13 views
  • 28 Jan, 2021
  • 1 location
Kisspeptin in the Evaluation of Delayed Puberty

Some children with delayed puberty will eventually enter puberty on their own. However, some children with delayed puberty have a permanent condition and require medical treatment to undergo puberty. Right now, there is no reliable diagnostic tool to tell whether a child's delayed puberty will be self-resolving or permanent. The …

estradiol
testosterone level
testosterone
insulin-like growth factor 1 (igf-1)
kisspeptin
  • 23 views
  • 27 Jan, 2021
Aromatase Inhibitors and Weight Loss in Severely Obese Men With Hypogonadism

The investigators have preliminary data suggesting that obese patients with hypogonadotropic hypogonadism (HHG) have minimal benefit from testosterone therapy likely because of its conversion to

behavior modification
testosterone
androgens
gonadotropin
pituitary
  • 941 views
  • 30 Jan, 2021
  • 1 location