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Found 54 clinical trials
Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate

The purpose of this study is to explore the genetic basis of reproductive disorders and cleft lip and/or palate.

klinefelter syndrome
Accepts healthy volunteers
secondary hypogonadism
precocious puberty
kallmann syndrome
  • 10 Jul, 2022
  • 1 location
The Molecular Basis of Inherited Reproductive Disorders

Background During puberty, children begin to develop into adults. Problems with the hormones released during puberty can affect the reproductive system. Some people have low hormone levels that severely delay or prevent puberty. Others start puberty abnormally early. Other people may have a normal puberty but develop reproductive disorders later …

klinefelter syndrome
hormone levels
early puberty
secondary hypogonadism
  • 17 Sep, 2022
  • 2 locations
GROWing Up With Rare GENEtic Syndromes

GROWing Up With Rare GENEtic Syndromes: Introduction Rare complex syndromes Patients with complex genetic syndromes, by definition, have combined medical problems affecting multiple organ systems, and intellectual disability is often part of the syndrome. During childhood, patients with rare genetic syndromes receive multidisciplinary and specialized medical care; they usually receive …

rare diseases
congenital disorders
genetic disorder
diagnostic tests
  • 09 Feb, 2021
  • 1 location
Swiss Austrian German Testicular Cancer Cohort Study - SAG TCCS

from therapy, including hypogonadism, metabolic syndrome, cardiovascular disease and secondary malignancies. The Swiss Austrian German Testicular Cancer Cohort Study (SAG TCCS) will comprise

cardiovascular disease
renal function tests
  • 09 Aug, 2021
  • 1 location
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (CoRDS)

CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures …

other disease
rare diseases
  • 15 Jul, 2022
  • 2 locations
Minipuberty in Infants Born With Potential Hypogonadism Hypogonadotrope (MiniNO)

clitoral hypertrophy in female infants. Genetic, hormonal and environmental factors are implicated in DSD. Infants with congenital hypogonadism hypogonadotrope (CHH) can present with DSD. Evaluation of

Accepts healthy volunteers
  • 11 Aug, 2022
  • 1 location
Endocrine, Metabolic, Cardiovascular and Immunological Aspects of Sex Chromosome Abnormalities in Relation to Genotype (EMKISCA)

Observational study of 160 patients with sex-chromosome abnormalities and 160 matched controls. Blood, fat, muscle, skin, buccal swaps, urine will be collected and analyzed for DNA, RNA and methylation patterns. The goal is to associated genotype and epigenetic changes with the phenotype of patients with sex-chromosome abnormalities. Patients participate in …

chromosomal abnormality
chromosomal disorder
Accepts healthy volunteers
  • 08 Jul, 2022
  • 1 location
The Role of Gonadotropin Pulsations in the Regulation of Puberty and Fertility

Background The body produces gonadotropin-releasing hormone (GnRH) about every 2 hours. GnRH travels through the bloodstream to the pituitary gland, where it stimulates the gland to produce hormones called gonadotropins. These hormones stimulate the testicles or ovaries. The testicles produce testosterone and develop sperm. The ovaries produce estrogen and prepare …

hypogonadotropic hypogonadism
klinefelter syndrome
hormone levels
  • 14 Sep, 2022
  • 1 location
Bariatric Surgery and Male Reproductive Function

dysfunction. It is reported to have a prevalence of approximately 45% in moderate to severe obesity. In addition, studies have pointed out that the prevalence of hypogonadism in men with type 2 diabetes and

  • 20 Mar, 2021
  • 1 location
Perioperative Testosterone Replacement Therapy in Sarcopenic Male Colorectal Cancer Patients (TERESA)

With increasing age and the additional impact from the bowel cancer and the chemotherapy and/ or radiotherapy it has been described that testosterone (a male hormone produced naturally in the body) levels are reduced. Testosterone has an impact on numerous body functions including the muscle mass and quality. Previous studies …

body mass index
  • 25 May, 2022
  • 1 location