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Found 54 clinical trials
A Study of the Effect of Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism

with primary, and in some cases, secondary hypogonadism includes administration of testosterone. Testim® and Fortesta® are topical gels that when applied daily help to increase the total

androgens
secondary hypogonadism
testim
aveed injectable product
serum testosterone
  • 140 views
  • 28 May, 2022
  • 24 locations
A Phase 3, Double-blind, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK Inhibitor Therapy and Who Require Red Blood Cell Transfusions (INDEPENDENCE)

The purpose of this Phase 3 study is to evaluate the efficacy and safety of Luspatercept compared with placebo in subjects with myeloproliferative neoplasm (MPN)-associated Myelofibrosis (MF) and anemia on concomitant Janus kinase 2 (JAK2) inhibitor therapy and who require red blood cell count (RBC) transfusions. The study is divided …

cancer
vasectomy
bilateral oophorectomy
anemia
  • 29 views
  • 22 Sep, 2022
  • 136 locations
Opioid Antagonism in Hypogonadotropic Hypogonadism

The goal of this study is to evaluate the effects of opioid antagonists on the hypothalamic-pituitary-gonadal axis in subjects with idiopathic hypogonadotropic hypogonadism (HH).

klinefelter syndrome
secondary hypogonadism
idiopathic hypogonadotropic hypogonadism
kisspeptin
pituitary
  • 0 views
  • 07 Jul, 2022
  • 1 location
Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism

The goal of this study is to develop novel treatments for patients with a condition called hypogonadotropic hypogonadism (HH) through the use of exogenous kisspeptin.

klinefelter syndrome
secondary hypogonadism
kisspeptin
  • 0 views
  • 08 Jul, 2022
  • 1 location
Efficacy and Safety of Long Term Use of hCG or hCG Plus hMG in Males With Isolated Hypogonadotropic Hypogonadism (IHH) (IHH)

This study will evaluate the efficacy and safety of long term use of hCG alone or hCG plus hMG in the treatment of male patients with isolated hypogonadotropic hypogonadism (IHH). One third of

secondary hypogonadism
serum fsh level
menotropins
follicle stimulating hormone
gonadotropin
  • 156 views
  • 04 Mar, 2022
  • 1 location
Aromatase Inhibitors and Weight Loss in Severely Obese Men With Hypogonadism

The investigators have preliminary data suggesting that obese patients with hypogonadotropic hypogonadism (HHG) have minimal benefit from testosterone therapy likely because of its conversion to

androgens
gonadotropin
behavior modification
estrogen
klinefelter syndrome
  • 1129 views
  • 24 Mar, 2022
  • 1 location
Testosterone Therapy and Bone Quality in Men With Diabetes and Hypogonadism

Low testosterone and diabetes mellitus are each associated with increased risk for fractures. Men with diabetes mellitus are commonly found to have low testosterone as well. Testosterone has been shown to improve the bone health of patients with low testosterone but has not been tested in patients who also have …

diabetes
androgens
androgen deficiency
testosterone
sugars
  • 133 views
  • 27 Feb, 2022
  • 1 location
Neuropeptides in Human Reproduction

The investigators are seeking healthy volunteers and volunteers with reproductive disorders for the study of the role of dynorphin in the reproductive system. Dynorphin is a naturally occurring opioid hormone that is blocked by naloxone. We hypothesize that naloxone, by blocking dynorphin, will stimulate production of GnRH and kisspeptin, 2 …

secondary hypogonadism
reproductive hormones
thyroid stimulating hormone
gonadotropin
Accepts healthy volunteers
  • 98 views
  • 07 Jul, 2022
  • 1 location
Efficacy of Prolonged GnRH Test in Male Adolescents With Postoperative HH

The Hypogonadotropic Hypogonadism(HH) could be caused by sellar lesions, sellar surgery or sellar radiotherapy. The incidence of HH after sellar surgery was higher in men than in women, and the

klinefelter syndrome
luteinizing hormone
secondary hypogonadism
stimulation test
gonadotropin
  • 0 views
  • 25 Mar, 2022
  • 1 location
A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects of Therapy With Letrozole and hUman Choriongonadotropin in Male Hypogonadism Induced by Illicit Use of Anabolic Androgenic Steroids- The LUCAS Trial

The overall objective of this randomized trial is to investigate the effects of treatment of AAS- induced male hypogonadism with combined therapy of letrozole and hCG compared with placebo on

testosterone level
hormone levels
screening procedure
testosterone
male hypogonadism
  • 0 views
  • 23 Mar, 2022
  • 1 location