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Found 10 clinical trials
A Safety, Tolerability, and Efficacy Study of VC-02™ Combination Product in Subjects With Type 1 Diabetes Mellitus and Hypoglycemia Unawareness

VC02-101 will evaluate an experimental cell replacement therapy intended to provide a functional cure to subjects with Type 1 Diabetes and Hypoglycemia Unawareness.

  • 958 views
  • 28 Apr, 2022
  • 5 locations
Restoration of Hypoglycemia Awareness With Metoclopramide

determine whether metoclopramide can improve hypoglycemia awareness and decrease the incidence of hypoglycemia in type 1 diabetes patients with hypoglycemia unawareness.

  • 42 views
  • 15 Mar, 2022
  • 1 location
Restoration of Hypoglycemia Awareness With Home-based High Intensity Interval Training

The objective of this study is to investigate if the addition of a 12-week program of home-based high intensity interval training to a standard educational program aiming at preventing hypoglycemia episodes will restore hypoglycemia awareness in people living with type 1 diabetes and impaired awareness of hypoglycemia to a further …

flash
insulin
hypoglycemic agents
hemoglobin a1c
hypoglycemia
  • 0 views
  • 29 Aug, 2021
  • 1 location
Islet Transplant in Patients With Type I Diabetes

control and a history of severe hypoglycemic episodes with hypoglycemia unawareness.

insulin treatment
pancreatic islet transplantation
insulin
hypoglycemic drugs
severe hypoglycaemia
  • 0 views
  • 25 Jan, 2021
  • 1 location
A Safety, Tolerability and Efficacy Study of Sernova's Cell Pouch™ for Clinical Islet Transplantation

Diabetes Mellitus (T1DM) with hypoglycemia unawareness and a history of severe hypoglycemic episodes. Upon implantation, the Cell Pouch™ is designed to form a natural environment, rich in tissue and

tolerance test
c-peptide
self monitoring
pancreatic islet transplantation
insulin
  • 117 views
  • 24 Mar, 2022
  • 1 location
Continuous Glucose Monitoring Initiation at Hospital Discharge

The purpose of this study is to look at feasibility (the likelihood) of continued use of the FreeStyle Libre 2 Continuous glucose monitor (CGM) when started at the time of hospital discharge in patients with poorly controlled diabetes and to look at the effects of CGM use on blood glucose …

  • 0 views
  • 30 Apr, 2021
Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes

Almost all people who have had type 1 diabetes for 5 years have a defect in secretion of the hormone Glucagon. This hormone is involved in the body's response to low blood glucose (hypoglycaemia). It works by releasing glucose stores from the liver to bring the blood glucose back to …

c-peptide
insulin
kidney function tests
hypoglycemic agents
injection of insulin
  • 0 views
  • 24 Mar, 2022
  • 1 location
Novel Method of Pancreatic Islet Transplantation Into the Omentum

The investigators propose to conduct a pilot clinical study in 10 type 1 diabetic subjects suffering from hypoglycemia unawareness syndrome and episodes of severe hypoglycemia, in which therapy

  • 0 views
  • 05 Sep, 2021
  • 1 location
Automated Insulin Delivery in Elderly With Type 1 Diabetes (AIDE T1D)

A multi-center, randomized, crossover trial consisting of three sequential 12-week periods, with the HCL feature used during one period, the PLGS feature used during one period and SAP therapy (control) during one period. The crossover trial will be preceded by a run-in phase in which participants will receive training using …

Accepts healthy volunteers
  • 0 views
  • 26 Apr, 2021
  • 4 locations
Individualised Postprandial Glucose Responses in Type 1 Diabetes

Type 1 diabetes (T1D) is a lifelong disease which stops the body from producing insulin - an important hormone that controls blood sugar (glucose) levels. People with T1D use insulin replacement therapy, usually in the form of injections, to help control blood glucose levels, however keeping glucose levels within normal …

diabetic ketoacidosis
insulin
sugars
treatment regimen
diabetes
  • 0 views
  • 25 Mar, 2022