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Found 30 clinical trials
A Phase 3, Multi-Center, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy and Safety of CK-3773274 in Adults With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction (SEQUOIA-HCM)

The purpose of this study is to evaluate the efficacy and safety of aficamten (CK-3773274) in adults with symptomatic hypertrophic cardiomyopathy and left ventricular outflow tract obstruction

  • 20 Sep, 2022
  • 32 locations
REDWOOD-HCM: Randomized Evaluation of Dosing With CK-3773274 in HCM (REDWOOD-HCM)

This study is being performed to understand the effect of different doses of CK-3773274 on patients with hypertrophic cardiomyopathy (HCM).

beta blockers
  • 06 Apr, 2022
  • 21 locations
PVP-Guided Decongestive Therapy in HF (PERIPHERAL-HF)

The investigators hypothesize that a simple assessment of peripheral venous pressure (PVP) will better predict the diuretic need and long-term outcomes (all cause mortality, all cause rehospitalization, emergency department visits) compared to standard evaluation.

chronic heart failure
diuretic therapy
heart failure
  • 23 Mar, 2022
  • 2 locations
Pacing for Hypertrophic Obstructive Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy (HOCM) is an inherited cardiac condition which causes the heart muscle to become abnormally thick causing obstruction of blood flow in the heart. This

chest pain
implantable cardioverter defibrillator
  • 18 Apr, 2022
Esmolol for Myocardial Protection in Hypertrophic Obstructive Cardiomyopathy

influence of esmolol in patients with hypertrophic obstructive cardiomyopathy undergoing cardiac surgery.

  • 19 Oct, 2021
  • 1 location
Surgical Septal Myectomy vs Percutaneous Transluminal Alcohol Septal Ablation in Patients With Hypertrophic Obstructive Cardiomyopathy

The aim of this randomized trial is to compare the improvement in exercise capacity among patients with highly symptomatic hypertrophic obstructive cardiomyopathy despite optimal medical

  • 24 Sep, 2021
  • 1 location
The Clinical Research of the Safety and Effectiveness Evaluation for Using Minimally Invasive Transapical Septal Myectomy System to Treat Hypertrophic Obstructive Cardiomyopathy

Objectives of Study: To evaluate the the safety and effectiveness of Using Minimally invasive Transapical septal myectomy System to Treat Hypertrophic Obstructive Cardiomyopathy. The

  • 06 May, 2022
  • 1 location
Effect of Metoprolol in Post Alcohol Septal Ablation Patients With Hypertrophic Cardiomyopathy

In this trial, the investigators will assess the effect of metoprolol in patients with hypertrophic cardiomyopathy who underwent alcohol septal ablation. The investigators will evaluate the quality of life, exercise tolerance, echocardiographic parameters and laboratory marker of heart failure and myocardial injury.

septal ablation
heart failure
  • 23 Mar, 2022
  • 1 location
Will Elevated Left Ventricle Filling Pressures Decrease by a Group Exercise Program in Patients With Hypertrophic CardioMyopathy? (WEDGE-HCM)

Aims and objectives: The primary objective of this study is to assess whether a structured exercise program improves cardiac relaxing properties in patients with hypertrophic cardiomyopathy (HCM). Background: HCM is a hereditary disease in which the myocardium becomes thickened without an identifiable cause (other than genetic). It is the most …

cardiopulmonary exercise test
hereditary disease
cardiopulmonary exercise testing
  • 10 Mar, 2022
  • 1 location
The Efficacy and Mechanism of Trientine in Patients With Hypertrophic Cardiomyopathy

This research study has been designed to test whether a drug called trientine dihydrochloride (also called Cufence) reduces heart muscle thickening, improves exercise capacity, improves heart function and reduces abnormal heart rhythms in patients with hypertrophic cardiomyopathy (HCM). The study is also assessing how trientine works in HCM. Participants will …

  • 26 Mar, 2021
  • 4 locations