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Found 152 clinical trials
Soy Modulation of Immune Activation, LDL- Levels, and Lowering Inflammation by Pretzel Isoflavone Dietary Intervention (SMALL LIPIDS)

Combination antiretroviral therapy (ART, HIV medications) dramatically increases the expected lifespan of HIV (Human Immunodeficiency Virus)infected patients; yet, the risks for cardiovascular disease (CVD), such as heart attacks and stroke, are increased in this population. This increased risk may be linked to persistent inflammation and activation of the immune system. …

HIV Vaccine
low density lipoprotein
fasting
atazanavir
hiv-1 antigen
  • 11 views
  • 16 Oct, 2022
  • 1 location
Community-based E-Health Program for Older Adults Living With Chronic Diseases (CeHP)

With increased aging population, there is a higher rate of having chronic diseases and cognitive impairment. In order to achieve successful aging, it is important for community-dwelling older adults to perform better self-management with improved health literacy and various kinds of support. The study aims to develop a Community-based E-Health …

hyperlipidemia
diabetes
Accepts healthy volunteers
hypertension
  • 0 views
  • 25 Mar, 2022
  • 2 locations
Efficacy and Safety of Pitavastatin and PCSK9 Inhibitors in Liver Transplant Patients (PINTL)

To study the efficacy and safety of pitavastatin and PCSK9 inhibitors in liver transplant patients on ongoing immunosuppressive therapy.

atherosclerosis
hyperlipidemia
pcsk9
lipid-lowering therapy
fenofibrate
  • 0 views
  • 07 Oct, 2022
  • 1 location
PET Imaging of Inflammation and Lipid Lowering Study

While 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging has been used as an early marker of drug efficacy in numerous clinical cardiovascular drug trials, as a glucose analog, its signal in the vasculature lacks inflammatory cell-specificity. Moreover, high background 18F-FDG signals from the myocardium often preclude coronary artery imaging, despite …

acute coronary syndrome
cholesterol level
18f-fdg
pcsk9
peripheral artery disease
  • 0 views
  • 30 Aug, 2021
  • 1 location
Investigating the Dose Response of an Almond-enriched Diet on Optimizing HDL-C in a Population With Hypercholesterolemia

This study will determine the quantity of almonds (1.5 oz or 2.5 oz) consumed as a snack that will provide optimal increases in HDL-C levels.

hypercholesterolemia
  • 0 views
  • 26 Mar, 2022
  • 1 location
Impact of Foods on Bile Acids, Metabolites, and Inflammation

Dietary incorporation of pulse crops may be an effective way to lower unhealthy elevations in serum bile acids. These elevations play a direct role in promoting obesity-related diseases estimated to be present in about one third of the US adult population, including non-alcoholic fatty liver disease and type 2 diabetes. …

bile acid
diabetes
fasting
body mass index
fatty liver
  • 0 views
  • 20 Apr, 2022
  • 1 location
Open-label, Phase 1b, Single-ascending Dose and Optional re Dosing Study to Evaluate the Safety of VERVE-101 Administered to Patients With Heterozygous Familial Hypercholesterolemia, Atherosclerotic Cardiovascular Disease, and Uncontrolled Hypercholesterolemia

VT-1001 is an open-label, phase 1b, single-ascending dose study that will evaluate the safety of VERVE-101 administered to patients with heterozygous familial hypercholesterolemia (HeFH), atherosclerotic cardiovascular disease (ASCVD), and uncontrolled hypercholesterolemia. VERVE-101 uses base-editing technology designed to disrupt the expression of the PCSK9 gene in the liver and lower circulating …

  • 0 views
  • 22 Oct, 2022
Statins in Reducing Events in the Elderly (STAREE) Heart Sub-study

The STAREE-HEART sub-study will examine the effect of statin treatment over a 3-year period compared with placebo on markers of cardiac ageing. This will include determining global longitudinal strain with transthoracic echocardiography, atrial fibrillation with home measures twice daily for two weeks and changes in biomarkers.

fibrillation
12 lead ECG
hmg-coa reductase inhibitors
diagnostic procedure
heart study
  • 10 views
  • 26 Jan, 2021
  • 1 location
Compassionate Use of Metreleptin in Previously-Treated Patients With Generalized Lipodystrophy

Background Generalized lipodystrophy can cause high blood fat levels and resistance to insulin. This can lead to health problems including diabetes. Researchers have found that the drug metreleptin improves health in people with this disease. Objective To test the safety and effectiveness of metreleptin. Eligibility People ages 6 months and …

insulin
metreleptin
blood test
x-rays
sweet
  • 14 views
  • 16 Oct, 2022
  • 1 location
Effect of Fish Oil on Hyperlipidemia and Toxicities in Children and Young Adults With Acute Lymphoblastic Leukemia

hyperlipidemia is high during initial ALL therapy. Studies have suggested that hyperlipidemia is a risk factor for development of osteonecrosis, thrombosis and possibly acute pancreatitis. Long-chained

lymphoid leukemia
acute leukemia
dexamethasone
asparaginase
pegaspargase
  • 1 views
  • 23 Jan, 2021
  • 4 locations